Tolcapone
Chemical Name: (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
Purity: ≥99%
Biological Activity
Tolcapone is a COMT inhibitor. Inhibits both brain and peripheral COMT. Also binds transthyretin (TTR) with high affinity (Kd1 and Kd2 values are 21 and 58 nM, respectively). Inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. Stabilizes TTR in mice and humans in vivo. Orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Different in vivo properties of three new inhibitors of catechol O-methyltransferase in the rat.
Männistö et al.
Br.J.Pharmacol., 1992;105:569 -
Repositioning tolc. as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity.
Sant'Anna et al.
Nat.Commun., 2016;7:10787
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