Torin 1

Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex.
Authors: Chin-Lee Et al.
iScience  2022;25:105458

Measuring Autophagic Cargo Flux with Keima-Based Probes.
Authors: Lisa B Et al.
Methods Mol Biol  2022;2445:99-115

Phosphorylation by casein kinase 2 enhances the interaction between ER-phagy receptor TEX264 and ATG8 proteins.
Authors: Koji L Et al.
EMBO Rep  2022;23:e54801

The FACT complex facilitates expression of lysosomal and antioxidant genes through binding to TFEB and TFE3.
Authors: Jose A Et al.
Autophagy  2022;18:2333-2349

SHISA5/SCOTIN restrains spontaneous autophagy induction by blocking contact between the ERES and phagophores.
Authors: Joo-Yeon Et al.
Autophagy  2022;18:1613-1628

Identification of a novel compound that simultaneously impairs the ubiquitin-proteasome system and autophagy.
Authors: Florian A Et al.
Autophagy  2022;18:1486-1502

DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy.
Authors: Catherine Et al.
Brain  2022;145:4368-4384

Targeting of Ubiquitin E3 Ligase RNF5 as a Novel Therapeutic Strategy in Neuroectodermal Tumors.
Authors: Alessandra Et al.
Cancers (Basel)  2022;14

SETD2 transcriptional control of ATG14L/S isoforms regulates autophagosome-lysosome fusion.
Authors: Daniel J Et al.
Cell Death Dis  2022;13:953

mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1.
Authors: Florian Et al.
Nat Commun  2022;13:4685

Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance.
Authors: Keith Et al.
Nat Commun  2022;13:4146

A novel ATG5 interaction with Ku70 potentiates DNA repair upon genotoxic stress.
Authors: Devrim Et al.
Sci Rep  2022;12:8134

Overexpressed Smurf1 is degraded in glioblastoma cells through autophagy in a p62-dependent manner.
Authors: Xinyi Et al.
FEBS Open Bio  2022;12:118-129

Novel Regulators of Macropinocytosis-Dependent Growth Revealed by Informer Set Library Screening in Pancreatic Cancer Cells.
Authors: Frank Et al.
Metabolites  2022;12

3D chromatin remodeling potentiates transcriptional programs driving cell invasion.
Authors: Adriana Et al.
Proc Natl Acad Sci U S A  2022;119:e2203452119

A pulse-chasable reporter processing assay for mammalian autophagic flux with HaloTag.
Authors: Noboru Et al.
Elife  2022;11

Local anesthetics elicit immune-dependent anticancer effects.
Authors: Peter Et al.
J Immunother Cancer  2022;10

Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress.
Authors: Jing Et al.
Mol Cell  2021;81:4191-4208.e8

mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis.
Authors: John M Et al.
Mol Cell  2021;81:2076-2093.e9

mTORC1 promotes cell growth via m6A-dependent mRNA degradation.
Authors: Joshua D Et al.
Mol Cell  2021;81:2064-2075.e8

Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individuals.
Authors: Qiong Et al.
Sci Immunol  2021;6

p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway.
Authors: Markus Et al.
Cell Stress  2021;5:176-182

FTLD Patient-Derived Fibroblasts Show Defective Mitochondrial Function and Accumulation of p62.
Authors: Päivi Et al.
Mol Neurobiol  2021;58:5438-5458

Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation.
Authors: Paul F Et al.
Dev Cell  2021;56:811-825.e6

NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C.
Authors: Roberto Et al.
Dev Cell  2021;56:260-276.e7

Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner.
Authors: David C Et al.
Dev Cell  2021;56:1961-1975.e5

Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin.
Authors: John M Et al.
Mol Metab  2021;53:101309

Genotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cGAS-STING pathway.
Authors: Neysan Et al.
Commun Biol  2021;4:831

The mTOR regulated RNA-binding protein LARP1 requires PABPC1 for guided mRNA interaction.
Authors: Carolyn Et al.
Nucleic Acids Res  2021;49:458-478

mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1.
Authors: An-Dao Et al.
Nucleic Acids Res  2021;49:3461-3489

Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease.
Authors: Andrew Et al.
Cell Rep  2021;36:109636

Amino acids and mechanistic target of rapamycin regulate the fate of live engulfed cells.
Authors: Michael Et al.
FASEB J  2021;35:e21909

Increased fidelity of protein synthesis extends lifespan.
Authors: Mario Et al.
Cell Metab  2021;33:2288-2300.e12

Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth.
Authors: Costas A Et al.
Cell Metab  2021;33:1013-1026.e6

pHLARE: a new biosensor reveals decreased lysosome pH in cancer cells.
Authors: Torsten Et al.
Mol Biol Cell  2021;32:131-142

Development of a specific live-cell assay for native autophagic flux.
Authors: Sami J Et al.
J Biol Chem  2021;297:101003

Oleate-induced aggregation of LC3 at the trans-Golgi network is linked to a protein trafficking blockade.
Authors: Guido Et al.
Cell Death Differ  2021;28:1733-1752

Rag GTPases and phosphatidylinositol 3-phosphate mediate recruitment of the AP-5/SPG11/SPG15 complex.
Authors: Anne-Claude Et al.
J Cell Biol  2021;220

Genistein Activates Transcription Factor EB and Corrects Niemann-Pick C Phenotype.
Authors: Juan Et al.
Int J Mol Sci  2021;22

Impaired TRIM16-Mediated Lysophagy in Chronic Obstructive Pulmonary Disease Pathogenesis.
Authors: Jun Et al.
J Immunol  2021;207:65-76

Comparing mTOR inhibitor Rapamycin with Torin-2 within the RIST molecular-targeted regimen in neuroblastoma cells.
Authors: Selim Et al.
Int J Med Sci  2021;18:137-149

TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy through regulation of lysosomal calcium.
Authors: Sung Hoon Et al.
Autophagy  2021;17:761-778

Trehalose causes low-grade lysosomal stress to activate TFEB and the autophagy-lysosome biogenesis response.
Authors: Joel D Et al.
Autophagy  2021;17:3740-3752

A high-throughput screening identifies ZNF418 as a novel regulator of the ubiquitin-proteasome system and autophagy-lysosomal pathway.
Authors: Hanna Et al.
Autophagy  2021;17:3124-3139

The DNA methyltransferase DNMT3A contributes to autophagy long-term memory.
Authors: Michael G Et al.
Autophagy  2021;17:1259-1277

Generation of mouse-human chimeric embryos.
Authors: Boyang Et al.
Nat Protoc  2021;16:3954-3980

Atg7 deficiency in microglia drives an altered transcriptomic profile associated with an impaired neuroinflammatory response.
Authors: Mathilde Et al.
Mol Brain  2021;14:87

Evidence for Lysosomal Dysfunction within the Epidermis in Psoriasis and Atopic Dermatitis.
Authors: Hans-Uwe Et al.
J Invest Dermatol  2021;141:2838-2848.e4

Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence.
Authors: M Et al.
Nat Commun  2021;12:5507

Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis.
Authors: Shuang Et al.
Nat Commun  2021;12:5214

Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24.
Authors: Yang Et al.
Nat Commun  2021;12:508

NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA.
Authors: Koji L Et al.
Nat Commun  2021;12:3292

Cdk5 and GSK3β inhibit fast endophilin-mediated endocytosis.
Authors: Konstantinos Et al.
Nat Commun  2021;12:2424

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals.
Authors: John M Et al.
Elife  2021;10

3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis.
Authors: Steven P Et al.
Mol Cell  2020;80:828-844.e6

Transient inhibition of mTOR in human pluripotent stem cells enables robust formation of mouse-human chimeric embryos.
Authors: Jingxin Et al.
Sci Adv  2020;6:eaaz0298

A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndrome.
Authors: Pier Paolo Et al.
Nature  2020;585:597-602

Decoy exosomes provide protection against bacterial toxins.
Authors: Derya Et al.
Nature  2020;579:260-264

Microglia promote glioblastoma via mTOR-mediated immunosuppression of the tumour microenvironment.
Authors: Jun Et al.
EMBO J  2020;39:e103790

mTORC2 Assembly Is Regulated by USP9X-Mediated Deubiquitination of RICTOR.
Authors: David C Et al.
Cell Rep  2020;33:108564

CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci.
Authors: Ignacio Et al.
Cell Rep  2020;33:108545

Protein Stability Buffers the Cost of Translation Attenuation following eIF2α Phosphorylation.
Authors: Anne Et al.
Cell Rep  2020;32:108154

BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells.
Authors: Christopher J Et al.
Cell Rep  2020;31:107474

The GATA Transcription Factor Gaf1 Represses tRNAs, Inhibits Growth, and Extends Chronological Lifespan Downstream of Fission Yeast TORC1.
Authors: Jürg Et al.
Cell Rep  2020;30:3240-3249.e4

Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition.
Authors: Jurre J Et al.
Cell Rep  2020;30:2729-2742.e4

Von Hippel-Lindau tumor suppressor (VHL) stimulates TOR signaling by interacting with phosphoinositide 3-kinase (PI3K).
Authors: Wonho Et al.
J Biol Chem  2020;295:2336-2347

The intraflagellar transport protein IFT20 controls lysosome biogenesis by regulating the post-Golgi transport of acid hydrolases.
Authors: Cosima T Et al.
Cell Death Differ  2020;27:310-328

Structure, lipid scrambling activity and role in autophagosome formation of ATG9A.
Authors: Satoru Et al.
Nat Struct Mol Biol  2020;27:1194-1201

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control.
Authors: Chen Et al.
Nat Cell Biol  2020;22:246-256

Effects of mTOR inhibitors on neuropathic pain revealed by optical imaging of the insular cortex in rats.
Authors: Bae Hwan Et al.
Brain Res  2020;1733:146720

Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis.
Authors: Yan Et al.
Autophagy  2020;16:1683-1696

De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy.
Authors: Vladimir Et al.
Autophagy  2020;16:1044-1060

MITF and TFEB cross-regulation in melanoma cells.
Authors: Valerie Et al.
PLoS One  2020;15:e0238546

The small GTPase Rab32 resides on lysosomes to regulate mTORC1 signaling.
Authors: Jing Et al.
J Cell Sci  2020;133

Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus.
Authors: JoAnn Et al.
Nat Commun  2020;11:6088

Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling.
Authors: Florian Et al.
Nat Commun  2020;11:5133

Phosphorylation of eukaryotic initiation factor-2α (eIF2α) in autophagy.
Authors: Guido Et al.
Cell Death Dis  2020;11:433

Macropinocytosis drives T cell growth by sustaining the activation of mTORC1.
Authors: Di Et al.
Nat Commun  2020;11:180

Microglial metabolic flexibility supports immune surveillance of the brain parenchyma.
Authors: Louis-Philippe Et al.
Nat Commun  2020;11:1559

Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability.
Authors: Sang Gyun Et al.
Nat Commun  2020;11:1416

Resolvin E1 is a pro-repair molecule that promotes intestinal epithelial wound healing.
Authors: Asma Et al.
Proc Natl Acad Sci U S A  2020;117:9477-9482

The small GTPase Rab32 resides on lysosomes to regulate mTORC1 signaling.
Authors: Jing Et al.
J Cell Sci  2020;

HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting.
Authors: Neubert Et al.
Autophagy  2019;:1

Lysophosphatidic acid represses autophagy in prostate carcinoma cells.
Authors: Roberto J Et al.
Biochem Cell Biol  2019;97:387-396

Mammalian cell growth dynamics in mitosis.
Authors: Scott R Et al.
Elife  2019;8

Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity.
Authors: Seyed Mehdi Et al.
Cell Rep  2019;29:3620-3635.e7

The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress.
Authors: Andreas Et al.
J Biol Chem  2019;294:8197-8217

NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression.
Authors: Masaya Et al.
Cell Rep  2019;28:1282-1295.e8

Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate.
Authors: Sica Et al.
Cell Rep  2019;27:820

Type 2 diabetes is associated with suppression of autophagy and lipid accumulation in β-cells.
Authors: Ji Et al.
J Cell Mol Med  2019;23:2890

ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C.
Authors: Daniel S Et al.
Nat Cell Biol  2019;21:1206-1218

Involvement of Lamin B1 Reduction in Accelerated Cellular Senescence during Chronic Obstructive Pulmonary Disease Pathogenesis.
Authors: Jun Et al.
J Immunol  2019;202:1428-1440

Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition.
Authors: Charles A Et al.
Nat Chem Biol  2019;15:776-785

MITF-MIR211 axis is a novel autophagy amplifier system during cellular stress.
Authors: Arzu Et al.
Autophagy  2019;15:375-390

Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis.
Authors: Hua Et al.
Autophagy  2019;15:1954-1969

TFEB-driven endocytosis coordinates MTORC1 signaling and autophagy.
Authors: Andrea Et al.
Autophagy  2019;15:151-164

VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.
Authors: Conrad C Et al.
Autophagy  2019;15:1082-1099

Primary cilia mediate mitochondrial stress responses to promote dopamine neuron survival in a Parkinson's disease model.
Authors: Dong-Hyung Et al.
Cell Death Dis  2019;10:952

Dysfunctional autophagy following exposure to pro-inflammatory cytokines contributes to pancreatic β-cell apoptosis.
Authors: Lambelet Et al.
Cell Death Dis  2018;9:96

Amino acids stimulate the endosome-to-Golgi trafficking through Ragulator and small GTPase Arl5.
Authors: Shi Et al.
Nat Commun  2018;9:4987

Is Ras a potential target in treatment against cutaneous squamous cell carcinoma?.
Authors: Li Et al.
J Cancer  2018;9:3373

mTOR-dependent phosphorylation controls TFEB nuclear export.
Authors: Napolitano Et al.
Nat Commun  2018;9:3312

Carbon monoxide-induced TFEB nuclear translocation enhances mitophagy/mitochondrial biogenesis in hepatocytes and ameliorates inflammatory liver injury.
Authors: Kim Et al.
Cell Death Dis  2018;9:1060

The Long-lived Protein Degradation Assay: an Efficient Method for Quantitative Determination of the Autophagic Flux of Endogenous Proteins in Adherent Cell Lines.
Authors: Nikolai Et al.
Bio Protoc  2018;8:e2836

mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation.
Authors: Xin Et al.
Mol Cell  2018;70:949-960.e4

Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy.
Authors: Lundquist Et al.
Mol Cell  2018;70:531

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells.
Authors: Georgilis Et al.
Cancer Cell  2018;34:85

Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance.
Authors: Yasuo Et al.
Cancer Cell  2018;33:985-1003.e7

Metabolic reprogramming of murine cardiomyocytes during autophagy requires the extracellular nutrient sensor decorin.
Authors: Gubbiotti Et al.
J Biol Chem  2018;293:16940

Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides.
Authors: Peter Et al.
Cell Metab  2018;28:817-832.e8

ULK1 O-GlcNAcylation Is Crucial for Activating VPS34 via ATG14L during Autophagy Initiation.
Authors: Pyo Et al.
Cell Rep  2018;25:2878

Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17.
Authors: Matsui Et al.
J Cell Biol  2018;217:2633

Lysosomal Protein Lamtor1 Controls Innate Immune Responses via Nuclear Translocation of Transcription Factor EB.
Authors: Hayama Et al.
J Immunol  2018;200:3790

Integration of Distinct ShcA Signaling Complexes Promotes Breast Tumor Growth and Tyrosine Kinase Inhibitor Resistance.
Authors: Ha Et al.
Mol Cancer Res  2018;16:894

HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution.
Authors: Tol Et al.
Autophagy  2018;14:437

The pro-oxidant adaptor p66SHC promotes B cell mitophagy by disrupting mitochondrial integrity and recruiting LC3-II.
Authors: Cosima T Et al.
Autophagy  2018;14:2117-2138

Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy.
Authors: Barutcu Et al.
Autophagy  2018;14:1586

Lifespan extension without fertility reduction following dietary addition of the autophagy activator Torin1 in Drosophila melanogaster.
Authors: Mason Et al.
PLoS One  2018;13:e0190105

Mapping the mammalian ribosome quality control complex interactome using proximity labeling approaches.
Authors: Zuzow Et al.
Mol Biol Cell  2018;

Tenovin-6 impairs autophagy by inhibiting autophagic flux.
Authors: Yuan Et al.
Cell Death Dis  2017;8:e2608

SYK kinase mediates brown fat differentiation and activation.
Authors: Lei Et al.
Nat Commun  2017;8:2115

Primary fibroblasts from CSPα mutation carriers recapitulate hallmarks of the adult onset neuronal ceroid lipofuscinosis.
Authors: Mark S Et al.
Sci Rep  2017;7:6332

TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer.
Authors: Cooper Et al.
Cancer Res  2017;77:5077

Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway.
Authors: Guerroue Et al.
Mol Cell  2017;68:786

m6A Facilitates eIF4F-Independent mRNA Translation.
Authors: Jun Et al.
Mol Cell  2017;68:504-514.e7

mTORC1 Phosphorylates Acetyltransferase p300 to Regulate Autophagy and Lipogenesis.
Authors: Li Et al.
Mol Cell  2017;68:323-335.e6

mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1.
Authors: Heidi M Et al.
Mol Cell  2017;67:922-935.e5

PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation.
Authors: Gupta Et al.
Mol Cell  2017;65:999

Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells.
Authors: Hung Et al.
Elife  2017;6

mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma.
Authors: Yong Ha Et al.
Dev Cell  2017;43:673-688.e5

DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy.
Authors: Nguyen Et al.
Dev Cell  2017;42:9

PtdIns3P controls mTORC1 signaling through lysosomal positioning.
Authors: Hong Et al.
J Cell Biol  2017;216:4217

Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9.
Authors: Schwartz Et al.
J Immunol  2017;198:3181

TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.
Authors: Laboucarié Et al.
EMBO Rep  2017;18:2197

Deubiquitinase OTUD6B Isoforms Are Important Regulators of Growth and Proliferation.
Authors: Sobol Et al.
Mol Cancer Res  2017;15:117

Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication.
Authors: Michael S Et al.
PLoS Pathog  2017;13:e1006635

The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy.
Authors: Pei Et al.
Autophagy  2017;13:2041

Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells.
Authors: Sinha Et al.
Autophagy  2017;13:169

Nonradioactive quantification of autophagic protein degradation with L-azidohomoalanine labeling.
Authors: Qingsong Et al.
Nat Protoc  2017;12:279-288

Tracking the Activity of mTORC1 in Living Cells Using Genetically Encoded FRET-based Biosensor TORCAR.
Authors: Jin Et al.
Curr Protoc Chem Biol  2016;8:225-233

The anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport.
Authors: Torgersen Et al.
Oncotarget  2016;7:86871

TSC loss distorts DNA replication programme and sensitises cells to genotoxic stress.
Authors: Pai Et al.
Oncotarget  2016;7:85365

Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomas.
Authors: Jennewein Et al.
Oncotarget  2016;7:20016

Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals
Authors: Kimura Et al.
Nature Communications  2016;7:13130

mTORC1 and CK2 coordinate ternary and eIF4F complex assembly.
Authors: Gandin Et al.
Nat Commun  2016;7:11127

mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex.
Authors: Pema Et al.
Mol Biol Cell  2016;7:10786

Trehalose, sucrose and raffinose are novel activators of autophagy in human keratinocytes through an mTOR-independent pathway.
Authors: Chen Et al.
PLoS One  2016;6:28423

LKB1 loss links serine metabolism to DNA methylation and tumorigenesis.
Authors: Kottakis Et al.
Nature  2016;539:390

An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK.
Authors: Hao Et al.
Proc Natl Acad Sci U S A  2016;5

Characterizing inactive ribosomes in translational profiling.
Authors: Liu
Translation (Austin)  2016;4:e1138018

Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP.
Authors: Ricoult Et al.
Oncogene  2016;35:1250

TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion.
Authors: Xia Et al.
EMBO J  2016;35:121

A novel Rab10-EHBP1-EHD2 complex essential for the autophagic engulfment of lipid droplets.
Authors: Li Et al.
Sci Adv  2016;2:e1601470

Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy.
Authors: Puente Et al.
J Biol Chem  2016;291:6026

RACK1 Is an Interaction Partner of ATG5 and a Novel Regulator of Autophagy.
Authors: Erbil Et al.
J Biol Chem  2016;291:16753

Human Cells Cultured under Physiological Oxygen Utilize Two Cap-binding Proteins to recruit Distinct mRNAs for Translation.
Authors: James Et al.
J Biol Chem  2016;291:10772-82

mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells.
Authors: Saric Et al.
Autophagy  2016;27:321

nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs.
Authors: Gandin Et al.
Genome Res  2016;26:636

Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis.
Authors: Kobayashi Et al.
J Immunol  2016;197:504

Neuronal gene repression in Niemann-Pick type C models is mediated by the c-Abl/HDAC2 signaling pathway.
Authors: Contreras Et al.
Biochim Biophys Acta  2016;1859:269

A Founder Mutation in VPS11 Causes an Autosomal Recessive Leukoencephalopathy Linked to Autophagic Defects.
Authors: Zhang Et al.
Cell Rep  2016;12:e1005848

Drosophila Mitf regulates the V-ATPase and the lysosomal-autophagic pathway.
Authors: Bouche Et al.
Autophagy  2016;12:484

Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling.
Authors: Choi Et al.
Autophagy  2016;12:1631

Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A.
Authors: Fernández Et al.
Autophagy  2016;12:1487

TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages.
Authors: Pastore Et al.
Autophagy  2016;12:1240

TP53INP2/DOR, a mediator of cell autophagy, promotes rDNA transcription via facilitating the assembly of the POLR1/RNA polymerase I preinitiation complex at rDNA promoters.
Authors: Xu Et al.
Autophagy  2016;12:1118

IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells.
Authors: Mao Et al.
Blood  2016;128:1475

IBMPFD Disease-Causing Mutant VCP/p97 Proteins Are Targets of Autophagic-Lysosomal Degradation.
Authors: Bayraktar Et al.
PLoS One  2016;11:e0164864

The Loss of Lam2 and Npr2-Npr3 Diminishes the Vacuolar Localization of Gtr1-Gtr2 and Disinhibits TORC1 Activity in Fission Yeast.
Authors: Ma Et al.
PLoS One  2016;11:e0156239

Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.
Authors: Holler Et al.
Mol Neurodegener  2016;11:46

A Small Molecule Screen Exposes mTOR Signaling Pathway Involvement in Radiation-Induced Apoptosis.
Authors: John S Et al.
ACS Chem Biol  2016;11:1428-37

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