Home / Protease-Activated Receptor Agonists / TRAP-6

TRAP-6

Catalog #: 3497
8 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3497/5
TRAP-6
1 Image
Description: PAR1 peptide fragment (residues 42-47); acts as a PAR1 agonist
Alternative Names: Thrombin receptor activator peptide 6

Purity: ≥95%

Product Details
Citations (8)
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Biological Activity

TRAP-6 is a peptide fragment (residues 42-47) of protease-activated receptor 1 (PAR1) that acts as a PAR1 agonist. Stimulates platelet aggregation (EC50 = 0.8 μM), promotes intracellular Ca2+ mobilization and induces rapid phosphodiesterase 3A (PDE3A) phosphorylation in vitro.

Technical Data

M.Wt:
748.88
Formula:
C34H56N10O9
Sequence:
SFLLRN
Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
141136-83-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for TRAP-6

The citations listed below are publications that use Tocris products. Selected citations for TRAP-6 include:

8 Citations: Showing 1 - 8

  1. SVEP1 is an endogenous ligand for the orphan receptor PEAR1
    Authors: Elenbaas Et al.
    Nat Commun  2023;14:850
  2. PAR-4/Ca2+-calpain pathway activation stimulates platelet-derived microparticles in hyperglycemic type 2 diabetes.
    Authors: Angelo Et al.
    Cardiovasc Diabetol  2021;20:77
  3. The Low Molecular Weight HP Tinzaparin Attenuates Platelet Activation in Terms of Metastatic Niche Formation by Coagulation-Dependent and Independent Pathways.
    Authors: Gockel Et al.
    Molecules  2018;23
  4. Unfractionated and Low Molecular Weight HP Reduce Platelet Induced Epithelial-Mesenchymal Transition in Pancreatic and Prostate Cancer Cells.
    Authors: Ponert Et al.
    Molecules  2018;23
  5. Arachidonic acid and Docosahexanoic acid enhance platelet formation from human apheresis-derived CD34+ cells.
    Authors: Dhenge Et al.
    Cell Cycle  2017;16:979
  6. Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells.
    Authors: Tripathi Et al.
    Invest Ophthalmol Vis Sci  2014;55:3912
  7. Role of SCH79797 in maintaining vascular integrity in rat model of subarachnoid hemorrhage.
    Authors: Yan Et al.
    Front Bioeng Biotechnol  2013;44:1410
  8. Arterial and venous endothelia display differential functional fractalkine (CX3CL1) expression by angiotensin-II.
    Authors: Andreas Et al.
    Arterioscler Thromb Vasc Biol  2013;33:96-104

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