Trichostatin A

Biological Activity

Trichostatin A is a selective and potent inhibitor of class I and II histone deacetylases (HDAC) (K_i = 3.4 nM, IC₅₀ values are 4.99 nM, 5.21 nM, 16.4 nM, 24.3 nM, 27.6 nM for HDAC1, 3, 6, 10 and 4, respectively). Trichostatin A induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells. Trichostatin A potently inhibits a range of breast cancer and melanoma cell lines (IC₅₀ = 29-400 nM) and induces apoptosis in prostate cancer cells. In an animal model of Huntington's disease, inhibition of HDAC by Trichostatin A rescues memory deficits and increases expression of CREB/CBP target genes in mutant mice. Activates autophagy, increases vesicular transport of BDNF (Cat. No. 2837) and is active in vivo.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
   Galluzzi et al.
   Nat.Rev.Drug.Discov., 2017;
2. Reprogramming primordial germ cells into pluripotent stem cells.
   Durcova-Hills et al.
   PloS ONE, 2008;3:e3531
3. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.
   Yoshida et al.
   J.Biol.Chem., 1990;265:17174
4. Inhibition of mitogenesis in Balb/c-3T3 cells by trichostatin A.
   Wharton et al.
   J.Biol.Chem., 2000;275:33981
5. Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo.
   Vigushin et al.
   Clin.Cancer Res., 2001;7:971

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