UFP-101

Catalog #: 1552
3 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
1552/1

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Description: Potent, selective silent antagonist for NOP

Alternative Names: [Nphe¹,Arg¹⁴,Lys¹⁵]Nociceptin-NH₂

Purity: ≥95%

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Product Details

Citations (3)

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Biological Activity

UFP-101 is a potent, selective and competitive silent antagonist for the NOP opioid receptor. Binds to NOP with high affinity (pK_i = 10.24) and displays > 3000-fold selectivity over δ, μ and κ opioid receptors. Antinociceptive and opposes the action of nociceptin in vivo.

Technical Data

M.Wt:

1908.19

Formula:

C₈₂H₁₃₈N₃₂O₂₁

Sequence:

GGGFTGARKSARKRKNQ

(Modifications: Gly-1 = N-(Bn)Gly, Gln-17 = C-terminal amide)

Solubility:

Soluble to 1 mg/ml in water

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

849024-68-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Nociceptin induces hypophagia in the perifornical and lateral hypothalamic area.
Parsons, Matthew, Burt, Julia, Cranford, Amanda, Alberto, Christia, Zipperlen, Katrin, Hirasawa, Michiru
PLoS ONE, 2012;7(9):e45350.
Blockade of nociceptin/orphanin FQ-NOP receptor signalling produces antidepressant-like effects: pharmacological and genetic evidences from the mouse forced swimming test.
Gavioli et al.
Eur.J.Neurosci., 2003;17:1987
[Nphe¹,Arg¹⁴,Lys¹⁵]Nociceptin-NH₂, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor.
Calo et al.
Br.J.Pharmacol., 2002;136:303
UFP-101, a high affinity antagonist for the nociceptin/orphanin FQ receptor: radioligand and GTPγ³⁵ binding studies.
McDonald et al.
Naunyn Schmiedebergs Arch.Pharmacol., 2003;367:183
Pharmacological profiles of presynaptic nociceptin/orphanin FQ receptors modulating 5-hydroxytryptamine and noradrenaline release in the rat neocortex.
Marti et al.
Br.J.Pharmacol., 2003;138:91

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for UFP-101

The citations listed below are publications that use Tocris products. Selected citations for UFP-101 include:

3 Citations: Showing 1 - 3

Nociceptin Receptor Is Overexpressed in Non-small Cell Lung Cancer and Predicts Poor Prognosis.
Authors: Wang Et al.
Front Oncol 2019;9:235
Modulation of silent and constitutively active nociceptin/orphanin FQ receptors by potent receptor antagonists and Na+ ions in rat sympathetic neurons.
Authors: Mahmoud Et al.
Mol Pharmacol 2010;77:804
Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors.
Authors: Kuzmin Et al.
Br J Pharmacol 2004;141:132

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