VU 0155069
Chemical Name: N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide
Purity: ≥98%
Biological Activity
VU 0155069 is a potent and selective phospholipase D1 (PLD1) inhibitor (IC50 values are 46 and 933 nM for PLD1 and PLD2 respectively). Inhibits migration of human and mouse breast cancer cell lines in transwell assays.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness.
Scott et al.
Nat.Chem.Biol., 2009;5:108 -
Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity.
Lewis et al.
Bioorg.Med.Chem.Lett., 2009;19:1916
Product Datasheets
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Citations for VU 0155069
The citations listed below are publications that use Tocris products. Selected citations for VU 0155069 include:
5 Citations: Showing 1 - 5
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CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic Vesicles.
Authors: Eckart D Et al.
Cell Rep 2020;30:2444-2459.e7
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An Antithrombotic Strategy by Targeting Phospholipase D in Human Platelets.
Authors: Lu Et al.
J Clin Med 2018;7
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Elevated phopholipase D isoform 1 in Alzheimer's disease patient' hippocampus. Relevance to synaptic dysfunction and memory deficits.
Authors: Krishnan Et al.
Alzheimers Dement (N Y) 2018;4:89
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PLD1 promotes dendritic spine development by inhibiting ADAM10-mediated N-cadherin cleavage.
Authors: Gang Et al.
Sci Rep 2017;7:6035
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PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D.
Authors: Sulzmaier Et al.
Oncogene 2012;31:3547
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