W-13 hydrochloride

Name: W-13 hydrochloride
Brand: Tocris Bioscience
SKU: 0361
Price: 149 USD

Catalog #: 0361
2 Citations Datasheet / COA / SDS

Discontinued Product

0361 has been discontinued.

View all Calcium Binding Protein Modulator Antagonists products.

W-13 hydrochloride | CAS No. 88519-57-7 | Calcium Binding Protein Modulator Antagonists

1 Image

Description: Calmodulin antagonist

Chemical Name: N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride

Purity: ≥98%

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Product Details

Citations (2)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

W-13 hydrochloride is a calmodulin antagonist (inhibits calmodulin activated PDE activity with an IC₅₀ of 68 μM). Inhibits growth of tamoxifen-resistant breast cancer cells.

Technical Data

M.Wt:

349.27

Formula:

C₁₄H₁₇ClN₂O₂S.HCl

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at RT

CAS No:

88519-57-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Transient Receptor Potential Canonical 1 (TRPC1) Channels as Regulators of Sphingolipid and VEGF Receptor Expression: IMPLICATIONS FOR THYROID CANCER CELL MIGRATION AND PROLIFERATION.
Asghar M, Magnusson M, Kemppainen K, Sukumaran P, Lof C, Pulli I, Kalhori V, Tornquist K
J Biol Chem, 2015;290(26):16116-31.
Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21^cip1.
Bosch et al.
J.Biol.Chem., 1998;273:22145
Naphthalenesulfonamides as calmodulin antagonists.
Hidaka and Tanaka
Methods Enzymol., 1983;102:185
Tamoxifen-resistant human breast cancer cell growth: inhibition by thionidazine, pim. and the calmodulin antagonist, W-13.
Stroble and Peterson
J.Pharmacol.Exp.Ther., 1992;263:186

Product Datasheets

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SDS

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Mass

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M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for W-13 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for W-13 hydrochloride include:

2 Citations: Showing 1 - 2

Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca(2+) in knock-out mouse models of polycystic kidney disease.
Authors: Yanda Et al.
J Biol Chem 2017;292:17897
Calmodulin activity regulates group I metabotropic glutamate receptor-mediated signal transduction and synaptic depression.
Authors: Sethna Et al.
J Neurosci Res 2016;94:401

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