W-5 hydrochloride
Chemical Name: N-(6-Aminohexyl)-1-naphthalenesulfonamide hydrochloride
Biological Activity
W-5 hydrochloride is a calmodulin antagonist (inhibits Ca2+-calmodulin dependent PDE with an IC50 of 240 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation.
Hidaka et al.
Proc.Natl.Acad.Sci.U.S.A., 1981;78:4354 -
Activity-structure relationship of calmodulin antagonists. Naphthalenesulfonamide derivatives.
Hidaka et al.
Mol.Pharmacol., 1981;20:571 -
Naphthalenesulfonamides as calmodulin antagonists.
Hidaka and Tanaka
Methods Enzymol., 1983;102:185
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Citation for W-5 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for W-5 hydrochloride include:
1 Citation: Showing 1 - 1
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Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release.
Authors: Long Et al.
PLoS Biol 2009;284:8726
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