WEB 2086

Catalog #: 2339
6 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
2339/10
2339/1

WEB 2086 | CAS No. 105219-56-5 | Platelet-activating Factor Receptor Antagonists

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Description: Potent PAF receptor antagonist

Alternative Names: Apafant

Chemical Name: 4-[3-[4[(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a]diazepin-2-yl]-1-oxopropyl]morpholine

Purity: ≥99%

View All Products for Platelet-activating Factor Receptor Antagonists

Product Details

Citations (6)

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Biological Activity

WEB 2086 is a potent, selective platelet-activating factor (PAF) receptor antagonist (K_i = 16.3 nM). Displays anti-inflammatory, antiangiogenic and anticancer activity. Inhibits growth and proliferation of MCF-7 breast cancer cells.

Technical Data

M.Wt:

455.96

Formula:

C₂₂H₂₂N₅O₂SCl

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol with gentle warming

Purity:

≥99%

Storage:

Desiccate at +4°C

CAS No:

105219-56-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Characterization of PAF receptors on human neutrophils using the specific antagonist, WEB 2086.
Dent et al.
FEBS Lett., 1989;244:365
Effects of WEB 2086 on the protective role of preconditioning against arrhythmias in rats.
Sariahmetoglu et al.
Pharmacol.Res., 1998;38:173
Growth inhibition and differentiation of human breast cancer cells by the PAFR antagonist WEB-2086.
Cellai et al.
Br.J.Cancer, 2006;94:1637

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Citations for WEB 2086

The citations listed below are publications that use Tocris products. Selected citations for WEB 2086 include:

6 Citations: Showing 1 - 6

Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice.
Authors: Wu Et al.
PLoS One 2014;9:e93003
A pepducin derived from the third intracellular loop of FPR2 is a partial agonist for direct activation of this receptor in neutrophils but a full agonist for cross-talk triggered reactivation of FPR2.
Authors: Gabl Et al.
PLoS One 2014;9:e109516
Macrophage derived platelet activating factor implicated in the resolution phase of gouty inflammation.
Authors: Yagnik
Int J Inflam 2014;2014:526496
Important role of platelets in modulating endotoxin-induced lung inflammation in CFTR-deficient mice.
Authors: Zhao Et al.
Br J Pharmacol 2013;8:e82683
Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes.
Authors: Ajiro Et al.
PLoS One 2011;301:H2395
Short-term stimulation of calcium-permeable transient receptor potential canonical 5-containing channels by oxidized phospholipids.
Authors: Al-Shawaf Et al.
Arterioscler Thromb Vasc Biol 2010;30:1453

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