WS 12
Chemical Name: (1R*,2S*)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide
Purity: ≥99%
Biological Activity
WS 12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 = 193 nM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators.
Beck et al.
Cell Calcium, 2007;41:285 -
Characterisation of TRPM8 as a pharmacophore receptor.
Bodding et al.
Cell Calcium, 2007;42:618
Product Datasheets
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Citations for WS 12
The citations listed below are publications that use Tocris products. Selected citations for WS 12 include:
2 Citations: Showing 1 - 2
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Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'.
Authors: Morgan Et al.
Biosci Rep 2015;35
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TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain.
Authors: Liu Et al.
Pain 2013;154:2169
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