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WS 383

Catalog #: 7055 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7055/50
7055/10
WS 383 | CAS No. 2247544-02-9 | Ubiquitin Ligase (E3) Inhibitors
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Description: Potent, selective and reversible DCN1-UBC12 interaction inhibitor

Chemical Name: 5-[[2-[[(4-Chlorophenyl)methyl]thio]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]thio]-N,N-dimethyl-1H-tetrazole-1-ethanamine hydrochloride

Purity: ≥98%

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Biological Activity

WS 383 is a potent and reversible DCN1-UBC12 interaction inhibitor (IC50 = 11 nM). The compound displays selectivity for DCN1-UBC12 over inhibition of a panel of kinases. including Bruton's tyrosine kinase (BTK), cyclin-dependent kinases (CDKs) and epidermal growth factor receptor (EGFR). In vitro, WS 383 selectively inhibits cullin-3 neddylation over other cullins, and induces accumulation of p21, p27 and NRF2.

Technical Data

M.Wt:
498.45
Formula:
C18H20ClN9S2.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2247544-02-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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