WZ 4003

Catalog # Availability Size / Price Qty
5177/10
5177/50
WZ 4003 | CAS No. 1214265-58-3 | NUAK Inhibitors
1 Image
Description: Potent and selective NUAK1/2 inhibitor

Chemical Name: N-3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]propanamide

Purity: ≥98%

Product Details
Citations (3)
Reviews

Biological Activity

WZ 4003 is a potent and selective NUAK1/2 inhibitor (IC50 values are 20 and 100 nM respectively). Exhibits no significant inhibition against a panel of 139 kinases, including ten AMPK family members. Inhibits NUAK1-mediated MYPT1 phosphorylation. Also inhibits cell proliferation in U2OS cells.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of WZ 4003 is reviewed on the chemical probes website.

Technical Data

M.Wt:
496.99
Formula:
C25H29ClN6O3
Solubility:
Soluble to 50 mM in 1eq. HCl and to 20 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1214265-58-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for WZ 4003

The citations listed below are publications that use Tocris products. Selected citations for WZ 4003 include:

3 Citations: Showing 1 - 3

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