XAC

Catalog #: 3200
7 Citations Datasheet / COA / SDS

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XAC | CAS No. 1962928-23-9 | Non-selective Adenosine Receptor Antagonists

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Description: Adenosine receptor antagonist

Alternative Names: Xanthine amine congener

Chemical Name: N-(2-Aminoethyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide dihydrochloride

Purity: ≥98%

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Product Details

Citations (7)

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Biological Activity

XAC is an adenosine receptor antagonist (IC₅₀ values are 1.8 and 114 nM at A₁ and A₂ receptors respectively). Attenuates adenosine-induced vasodilation and exhibits proconvulsant activity in vivo.

Technical Data

M.Wt:

501.41

Formula:

C₂₁H₂₈N₆O₄.2HCl

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥98%

Storage:

Desiccate at RT

CAS No:

1962928-23-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC)
Morgan et al.
Life Sci., 1989;45:719
Effects of xanthine amine congener on hypoxic coronary resistance and venous and epicardial adenosine concentrations.
Sawmiller et al.
Cardiovasc.Res., 1994;28:604
Purification and characterization of the human adenosine A_2A receptor functionally expressed in Escherichia coli.
Wei? and Grisshammer
Eur.J.Biochem., 2002;269:82

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Citations for XAC

The citations listed below are publications that use Tocris products. Selected citations for XAC include:

7 Citations: Showing 1 - 7

Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions.
Authors: Canas Et al.
Eneuro 2019;5
An Adenosine Receptor for Olfaction in Fish.
Authors: Wakisaka Et al.
Curr Biol 2017;27:1437
Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor.
Authors: Aungraheeta Et al.
Blood 2016;128:2717
Application of BRET to monitor ligand binding to GPCRs.
Authors: Stoddart Et al.
Nat Methods 2015;12:661
Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress.
Authors: Kaster Et al.
Hepatology 2015;112:7833
Characterization by flow cytometry of fluorescent, selective agonist probes of the A(3) adenosine receptor.
Authors: Kozma Et al.
Biochem Pharmacol 2013;85:1171
Regulation of hippocampal cannabinoid CB1 receptor actions by adenosine A1 receptors and chronic caffeine administration: implications for the effects of δ9-tetrahydrocannabinol on spatial memory.
Authors: Sousa Et al.
Neuropsychopharmacology 2011;36:472

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