YM 022
Chemical Name: (R)-N-[2,3-Dihydro-1-[2-(2-methylphenyl)-2-oxoethyl]-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(3-methylphenyl)-urea
Purity: ≥99%
Biological Activity
YM 022 is an extremely potent and highly selective non-peptide CCK2 silent antagonist (Ki values are 68 pM and 63 nM at CCK2 and CCK1 receptors respectively). Acts in vivo to potently inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation with a long duration of action.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Small synthetic ligands of the cholecystokinin-B/gastrin receptor can mimic the function of endogenous peptide hormones.
Beinborn et al.
Yale J.Biol.Med., 1998;71:337 -
Long-lasting cholecystokinin2 receptor blockade after a single subcutaneous injection of YF476 or YM022.
Kitano et al.
Br.J.Pharmacol., 2000;130:699 -
Pharmacological profile of (R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea (YM022), a new potent and selective gastrin/cholecystokinin-B receptor antagonist, in vitro
Nishida et al.
J.Pharmacol.Exp.Ther., 1994;269:725
Product Datasheets
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Citations for YM 022
The citations listed below are publications that use Tocris products. Selected citations for YM 022 include:
4 Citations: Showing 1 - 4
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Cholecystokinin inhibits inducible nitric oxide synthase expression by lipopolysaccharide-stimulated peritoneal macrophages.
Authors: Saia Et al.
Mediators Inflamm 2014;2014:896029
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The dorsomedial hypothalamus mediates stress-induced hyperalgesia and is the source of the pronociceptive peptide cholecystokinin in the rostral ventromedial medulla.
Authors: Wagner Et al.
Neuropharmacology 2013;238:29
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Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-E2 in the spinal cord.
Authors: Marshall Et al.
Pain 2012;153:86
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Cholecystokinin inhibits endocannabinoid-sensitive hippocampal IPSPs and stimulates others.
Authors: Karson Et al.
Br J Pharmacol 2008;54:117
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