Zanamivir
Chemical Name: 5-(Acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-5-(Acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-D-glycero-D-galactonon-2-enonic acid-glycero-D-galactonon-2-enonic acid
Purity: ≥98%
Biological Activity
Zanamivir is an influenza viral neuraminidase inhibitor (IC50 values are 0.95 nM and 2.7 nM for influenza A and B, respectively). Inhibits neuraminidase, preventing the cleavage of sialic acid on the cell receptors, and release of the newly formed virions.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Comparison of the activities of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates of influenza virus and neuraminidase inhibitor-resistant variants.
Gubareva et al.
Antimicrob.Agents Chemother., 2001;45:3403 -
Zanamivir: from drug design to the clinic.
Elliott et al.
Philos.Trans.R.Soc.Lond.B.Biol.Sci., 2001;356:1885 -
Management of influenza virus infections with neuraminidase inhibitors: detection, incidence, and implications of drug resistance.
McKimm-Breschkin et al.
Treat Respir.Med., 2005;4:107
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