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Zaprinast

Catalog #: 0947
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0947/25
Zaprinast | CAS No. 37762-06-4 | Phosphodiesterase Inhibitors
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Description: GPR35 agonist

Chemical Name: 2-(2-Propyloxyphenyl)-8-azapurin-6-one

Purity: ≥98%

Product Details
Citations (6)
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Biological Activity

Zaprinast is a phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC50 values are 0.15, 0.76, 12.0 and 29.0 μM respectively). Putative GPR35 agonist.

Technical Data

M.Wt:
271.28
Formula:
C13H13N5O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
37762-06-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents.
    Lugnier
    Pharmacol.Ther., 2006;109:366
  2. Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35.
    Taniguchi et al.
    FEBS Lett., 2006;580:5003
  3. Isozyme-selective phosphodiesterase inhibitors as antiasthmatic agents.
    Christensen and Torphy
    Annu.Rep.Med.Chem., 1994;29:185
  4. Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases.
    Soderling et al.
    J.Biol.Chem., 1998;273:15553

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Citations for Zaprinast

The citations listed below are publications that use Tocris products. Selected citations for Zaprinast include:

6 Citations: Showing 1 - 6

  1. Mitochondrial remodeling and ischemic protection by G protein�coupled receptor 35 agonists.
    Authors: Wyant Et al.
    Science  2022;377:621
  2. Kynurenic acid and zaprinast diminished CXCL17-evoked pain-related behaviour and enhanced mor. analgesia in a mouse neuropathic pain model.
    Authors: Rojewska
    Pharmacol Rep  2018;71:139
  3. The antiallergic mast cell stabilizers lodox. and bufrolin as the first high and equipotent agonists of human and rat GPR35.
    Authors: MacKenzie Et al.
    Mol Pharmacol  2014;85:91
  4. Effect of the phosphodiesterase-5 inhibitor zaprinast on ischemia-reperfusion injury in rats.
    Authors: Polcari Et al.
    Proc Natl Acad Sci U S A  2013;27:338
  5. Ob receptor in rabbit ovary and leptin in vitro regulation of corpora lutea.
    Authors: Zerani Et al.
    J Endourol  2004;183:279
  6. Assessing the emetic potential of PDE4 inhibitors in rats.
    Authors: Robichaud Et al.
    Br J Pharmacol  2002;135:113

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