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Zosuquidar trihydrochloride

Catalog #: 5456
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5456/10
5456/50
Zosuquidar trihydrochloride | CAS No. 167465-36-3 | Multidrug Transporter Inhibitors
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Description: High affinity P-gp inhibitor
Alternative Names: LY 335979

Chemical Name: (αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanol trihydrochloride

Purity: ≥97%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Zosuquidar trihydrochloride is a high affinity P-glycoprotein (P-gp) inhibitor (Kd = 79 nM). Restores doxorubicin (Cat. No. 2252) sensitivity in P-gp-expressing multidrug (MDR) resistant cancer cell lines. Also potentiates antitumor efficacy of taxol (Cat. No. 1097) in a MDR human non-small cell lung carcinoma xenograft mouse model.

Technical Data

M.Wt:
636.99
Formula:
C32H31F2N3O2.3HCl
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
167465-36-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for Zosuquidar trihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Zosuquidar trihydrochloride include:

3 Citations: Showing 1 - 3

  1. Combinatorial Anticancer Drug Screen Identifies Off-Target Effects of Epigenetic Chemical Probes.
    Authors: Dalia Et al.
    ACS Chem Biol  2022;17:2801-2816
  2. A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity.
    Authors: Troy Et al.
    JCI Insight  2021;6
  3. Lower Tubulin Expression in Glioblastoma Stem Cells Attenuates Efficacy of Microtubule-Targeting Agents.
    Authors: Terrance G Et al.
    ACS Pharmacol Transl Sci  2019;2:402-413

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