TGF-beta Superfamily Modulators
TGF-beta, the prototypical member of the TGF-beta superfamily, acts as a potent growth inhibitor or stimulator of apoptosis in many cell types. The downstream signaling initiated by TGF-beta binding to its serine/threonine kinase receptor is carried out by members of the Smad family. In general, activation of Smad2 or Smad3 results in the formation of a heteromeric complex with Smad4 that translocates to the nucleus to regulate gene expression. R&D Systems offers a range of quality products that have been shown to modulate TGF-beta / Smad signaling cascades.
-
TGF-beta Superfamily Modulators - Cell Surface
-
TGF-beta Superfamily Modulators - Secreted
- BMP and Other Activin Receptor Activators
- BMP and Other Activin Receptor Inhibitors
- BMP-1/PCP
- Caronte
- Cerberus 1
- Chordin
- Chordin-like 1/CHRDL1
- Chordin-like 2/CHRDL2
- COCO
- Crossveinless-2/CV-2
- Cryptic
- DAN
- Decorin
- Dermatopontin
- Follistatin
- Follistatin-like 4/FSTL4
- Follistatin-like 5/FSTL5
- Follistatin-related Gene Protein/FLRG
- GASP-1/WFIKKN2
- GASP-2/WFIKKN
- Gremlin
- Nicalin
- Noggin
- PRDC/GREM2
- SOST/Sclerostin
- Latent TGF-beta bp1
- Latent TGF-beta bp2/LTBP-2
- Latent TGF-beta bp4
- TSG
- Tsukushi/TSK