Human Intermediate Monocyte Cell Markers

Click on one of the monocyte subsets shown in the buttons below to see the human and/or mouse markers that are commonly used to identify each cell type.

Human Classical/Mouse Ly-6C⁺ Monocyte Human Intermediate Monocyte Human Non-Classical/Mouse Ly-6C^- Monocyte

Cell Surface Markers

Lin^-

CD11b⁺

CD16/Fc gamma RIII⁺

CD163⁺

CCR2^mid

CCR5⁺

CX3CR1^high

HLA-DR^high

M-CSF R/CD115⁺

L-Selectin/CD62L⁺

CD14⁺⁺

Overview

In humans, the minor population of blood monocytes consists of the intermediate monocyte subset (CD14⁺⁺CD16⁺) and the non-classical monocyte subset (CD14⁺CD16⁺⁺), which together account for approximately 15% or less of the total blood monocyte population. Intermediate monocytes express medium levels of CCR2, high levels of CX3CR1, and are CCR5⁺. Like classical monocytes (CD14⁺⁺CD16^-), intermediate monocytes are thought to be recruited to sites of inflammation and have a pro-inflammatory effect. An increase in intermediate monocytes has been associated with a number of human inflammatory diseases including sepsis, rheumatoid arthritis, tuberculosis, HIV, and congestive heart failure.