The mature domains of each molecule were aligned using ClustalX [1]. The alignment was then processed with Protdist and Neighbor using the Dayhoff PAM Matrix [2]. The tree used as the basis for the dendrogram was created using TreeView [3]. The branches of the phylogenetic tree represent divergence of each branch member from a common ancestor. The branch lengths reflect the number of amino acid changes between each protein and that hypothetical ancestor, and imply how much time has passed since the divergence.
- Chenna, R. et al. (2003) Nucleic Acids Res. 31:3497.
- Felsenstein, J. (1989) Cladistics 5:164.
- Page, R. D. M. (1996) Computer Applications in the Biosciences 12:357.
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