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TWS 119

Catalog #: 3835 Datasheet / COA / SDS

Discontinued Product

3835 has been discontinued.
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TWS 119 | CAS No. 1507095-58-0 | GSK-3 Inhibitors
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Description: GSK-3β inhibitor; induces neuronal differentiation in ESCs

Chemical Name: 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxyphenol ditrifluoroacetate

Purity: ≥98%

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Biological Activity

TWS 119 is an inhibitor of glycogen synthase kinase-3β (IC50 = 30 nM). Induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs).

Technical Data

M.Wt:
546.38
Formula:
C18H14N4O2.2CF3CO2H
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
1507095-58-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Synthetic small molecules that control stem cell fate.
    Ding et al.
    Proc.Natl.Acad.Sci., 2003;100:7632
  2. Canonical wnt signaling maintains the quiescent stage of hepatic stellate cells.
    Kordes et al.
    Biochem.Biophys.Res.Comm., 2008;367:116

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