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Human MDM2/HDM2 Ubiquitin Ligase Kit - p53 Substrate

Catalog #: K-200B
4 Citations Datasheet / COA / SDS

Discontinued Product

K-200B has been discontinued.
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Citations (4)
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Summary Product Datasheets Background

Human MDM2/HDM2 Ubiquitin Ligase Kit - p53 Substrate Summary

Specifications

Shipping Conditions
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Human

Product Datasheets

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Product Datasheet
COA
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Background: MDM2/HDM2

MDM2 is a key regulator of p53 tumor suppressor protein activity and stability. MDM2 binds to and inhibits the transactivation domain of p53. In addition, MDM2 controls p53 stability by functioning as its E3 ligase in ubiquitination and by shuttling p53 from the nucleus to the cytoplasm for subsequent degradation. The importance of the p53/MDM2 relationship is underscored by the existence of an autoregulatory feedback loop whereby activated p53 transcriptionally upregulates the expression of its own inhibitor, MDM2.

Long Name
Double Minute 2 Protein
Entrez Gene IDs
4193 (Human); 17246 (Mouse)
Alternate Names
ACTFS; HDM2; HDMX; MDM2 oncogene, E3 ubiquitin protein ligase; MDM2

Citations for Human MDM2/HDM2 Ubiquitin Ligase Kit - p53 Substrate

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

4 Citations: Showing 1 - 4
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  1. CUL3 (cullin 3)-mediated ubiquitination and degradation of BECN1 (beclin 1) inhibit autophagy and promote tumor progression
    Authors: X Li, KB Yang, W Chen, J Mai, XQ Wu, T Sun, RY Wu, L Jiao, DD Li, J Ji, HL Zhang, Y Yu, YH Chen, GK Feng, R Deng, JD Li, XF Zhu
    Autophagy, 2021-05-12;0(0):1-18.  2021-05-12
  2. Extracellular matrix stiffness determines DNA repair efficiency and cellular sensitivity to genotoxic agents
    Authors: M Deng, J Lin, S Nowsheen, T Liu, Y Zhao, PW Villalta, D Sicard, DJ Tschumperl, S Lee, J Kim, Z Lou
    Science Advances, 2020-09-11;6(37):.  2020-09-11
  3. Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transfer
    Authors: AM Cathcart, GH Bird, TE Wales, HD Herce, EP Harvey, ZJ Hauseman, CE Newman, U Adhikary, MS Prew, T Oo, S Lee, JR Engen, LD Walensky
    Nat. Chem. Biol., 2020-08-17;0(0):.  2020-08-17
  4. MDM2 promotes genome instability by ubiquitinating the transcription factor HBP1
    Authors: Z Cao, J Xue, Y Cheng, J Wang, Y Liu, H Li, W Jiang, G Li, Y Gui, X Zhang
    Oncogene, 2019-02-28;0(0):.  2019-02-28

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