PRR5: Products

PRR5 (Pro-rich protein 5; also Protor-1) is a 42-46 kDa member of the Protor family of proteins. It is widely expressed, and forms part of mTORC2, an enzyme complex that regulates Atk and PKC alpha. At present, it appears PRR5 promotes mTORC2 activity. Human PRR5 is 388 amino acids (aa) in length. It possesses two RICTOR-interaction sites (aa 10-95 and 188-218) and a C-terminal Pro-rich region. There are multiple splice forms of PRR5. Either individually, or in-common, there is an alternate start site at Met10 (beta isoform) and Met96 (gamma isoform), a deletion of aa 45-71, 161-388, and 236-388, a 17 aa insertion after Gly108, and a six aa substitution for aa 1-107. Over aa 26-259 of the 41 kDa beta isoform (NP_056181), there is 95% aa identity between human and mouse PRR5.