AT 101
Chemical Name: (-)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde
Purity: ≥98%
Biological Activity
AT 101 is a R-(-)-enantiomer of gossypol (Cat. No. 1964). Mimics the BH3 domains of Bcl-2, Bcl-XL and Mcl-1. Disrupts heterodimerization of Bcl-2 with proapoptotic family members. Induces apoptosis in vitro through activation of caspase-9; cytotoxic to multiple myeloma and drug-resistant cell lines. Delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance.
Balakrishnan et al.
Blood, 2009;113:149 -
R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma cells.
Kline et al.
Exp.Hematol., 2008;36:568 -
In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration.
Loberg et al.
Neoplasia, 2007;9:1030
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Citation for AT 101
The citations listed below are publications that use Tocris products. Selected citations for AT 101 include:
1 Citation: Showing 1 - 1
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Androgen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells.
Authors: Chen Et al.
World J Gastroenterol 2016;11:e0156145
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