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Gossypol

Catalog #: 1964
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1964/50
Gossypol | CAS No. 303-45-7 | Additional Bcl-2 Family Compounds
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Description: Proapoptotic; downregulates Bcl-2 and Bcl-XL

Chemical Name: 1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Gossypol is a lipophilic agent derived from cottonseed. Exhibits multiple biological effects including antifertility and anticancer activity. Proapoptotic; downregulates Bcl-2 and Bcl-XL.

R-enantiomer also available.

Technical Data

M.Wt:
518.56
Formula:
C30H30O8
Solubility:
Soluble to 25 mM in ethanol with gentle warming and to 25 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
303-45-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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Citations for Gossypol

The citations listed below are publications that use Tocris products. Selected citations for Gossypol include:

3 Citations: Showing 1 - 3

  1. Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101).
    Authors: Mani Et al.
    PLoS One  2015;15:224
  2. Involvement of Smac, p53, and caspase pathways in induction of apoptosis by gossypol in human retinoblastoma cells.
    Authors: Hsiao Et al.
    Mol Vis  2012;18:2033
  3. (-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.
    Authors: Pang Et al.
    Mol Cancer Ther  2011;10:795

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