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Auxinole

Catalog #: 7894 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7894/50
7894/10
Auxinole | CAS No. 86445-22-9 | Molecular Glues
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Description: Auxin antagonist of TIR1/AFB receptors; also OsTIR1 inhibitor in auxin-inducible degron (AID) system

Chemical Name: α-[2-(2,4-Dimethylphenyl)-2-oxoethyl]-1H-indole-3-acetic acid

Purity: ≥98%

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Biological Activity

Auxinole is an auxin antagonist of TIR1/AFB receptors. Binds to TIR1 to block the formation of the TIR1-IAA-Aux/IAA complex and inhibit auxin-responsive gene expression. Auxinole competitively inhibits various auxin responses in planta. Auxinole also inhibits OsTIR1 that suppresses leaky degradation of degron-fused proteins. Can be used as a control compound with 5-Ph-IAA (Cat. No. 7392) in the AID2 degron system to switch off degradation.

Technical Data

M.Wt:
321.37
Formula:
C20H19NO3
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
86445-22-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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