Benzamil
Chemical Name: N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride
Purity: ≥98%
Biological Activity
Benzamil is a Na+/Ca2+ exhanger (NCX) inhibitor (IC50 ~ 100 nM); TRPP3 channel blocker (IC50 = 1.1 μM for inhibition of Ca2+-activated TRPP3 channel activity). Also non-selective Deg/ENaC family blocker; reduces mechanosensitivity of colonic afferents. More potent derivative of amiloride (Cat. No. 0890).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Characterization of a Na+-Ca2+ exchanger in podocytes.
Fischer et al.
Nephrol.Dial.Transplant., 2002;17:1742 -
Acid sensing ion channels 2 and 3 are required for inhibition of visceral nociceptors by benzamil.
Page et al.
Pain, 2007;133:150 -
Inhibition of TRPP3 channel by amil. and analogs.
Dai et al.
Mol.Pharmacol., 2007;72:1576
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for Benzamil
The citations listed below are publications that use Tocris products. Selected citations for Benzamil include:
5 Citations: Showing 1 - 5
-
Development of Orthogonal Linear Separation Analysis (OLSA) to Decompose Drug Effects into Basic Components.
Authors: Mizuno Et al.
Sci Rep 2019;9:1824
-
Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity.
Authors: Panja Et al.
Neuropathol Appl Neurobiol 2019;45:141
-
Determination of system level alterations in host transcriptome due to Zika virus (ZIKV) Infection in retinal pigment epithelium.
Authors: Singh
Sci Rep 2018;8:11209
-
Knockout of mitochondrial voltage-dependent anion channel type 3 increases reactive oxygen species (ROS) levels and alters renal sodium transport.
Authors: Zou Et al.
J Biol Chem 2018;293:1666
-
Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes.
Authors: Agarwal Et al.
Neuron 2017;93:587
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for Benzamil
There are currently no reviews for this product. Be the first to review Benzamil and earn rewards!
Have you used Benzamil?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
