Bioactivity of Blood Coagulation Proteins

Get Superior Bioactivity with R&D Systems^® Coagulation Proteins

R&D Systems is the world’s premiere source of recombinant proteins. Extensive quality control produces industry leading bioactivity and lot-to-lot consistency that instills confidence in results and ensures reproducibility.

Our recombinant proteins in the coagulation cascade are tested for activity in biologically relevant assays. If you need reagents that exhibit native function, you can rely on ours to give you results that make sense for coagulation biology. Every production lot of recombinant protein must meet our Quality Control specifications before we offer it for sale. That means you can count on each of these proteins to give you reliable and trustworthy results.

• Lot-to-lot consistency
• Biological activity
• Endotoxin level and microbial bioburden test
• Protein sequence accuracy
• Formulation

Select examples of bioactivity data for R&D Systems^® Coagulation Proteins (scroll down).

We offer bioactive proteins for each of these proteins involved in coagulation. We also offer an extensive selection of antibodies, immunoassays, small molecule regulators for these molecules. Click on the links to browse our catalog.

Coagulation Factors

Coagulation Cascade Proteases

Coagulation Cascade Protease Inhibitors

Plasmin/Plasminogen and Kallikrein/Kinin Systems

Other Coagulation Cascade Molecules

Thumbnails of activity data

Click on the graphs for a larger image

Kallikrein 5
Recombinant Human Kallikrein 5 (Catalog #1108-SE) cleaves the fluorogenic peptide substrate Boc-VPR-AMC (Catalog #ES011). The specific activity is >200 pmol/min/μg, as measured under the described conditions.

Serpin A1/alpha 1-Antitrypsin
Recombinant Human Serpin A1/alpha-1-Antitrypsin (Catalog #1268-PI) inhibits trypsin cleavage of a fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2 (Catalog #ES002). The IC₅₀ value is approximately <5.0 nM, as measured under the described conditions.

u-Plasminogen Activator (uPA)/Urokinase
Recombinant Human u-Plasminogen Activator/Urokinase (Catalog #1310-SE) cleaves a peptide substrate, N-carbobenzyloxy-Gly-Gly-Arg-7-amido-4-methylcoumarin (Z-GGR-AMC). The specific activity is >2,000 pmol/min/μg, as measured under the described conditions.

Kallikrein 3/PSA
Recombinant Human Kallikrein 3/PSA (Catalog #1344-SE) cleaves the colorimetric peptide substrate, Succinyl-Arg-Pro-Tyr-p-Nitroanilide (Suc-RPY-pNA). The specific activity is >70 pmol/min/μg, as measured under the described conditions.

Serpin E1/PAI-1
Recombinant Human Serpin E1/PAI-1 (Catalog #1786-PI) inhibits uPA cleavage of a peptide substrate, N-carbobenzyloxy-Gly-Gly-Arg-7-amido-4-methylcoumarin (Z-GGR-AMC). The IC₅₀ value is <13 nM, as measured under the described conditions.

Kallikrein 7
Recombinant Human Kallikrein 7 (Catalog #2624-SE) cleaves the fluorogenic peptide substrate Mca-RPKPVE-Nval-WRK(Dnp)-NH2 (Catalog #ES002). The specific activity is >150 pmol/min/µg, as measured under the described conditions.

Kallikrein 14
Recombinant Human Kallikrein 14 (Catalog #2626-SE) cleaves the fluorogenic peptide substrate Boc-VPR-AMC (Catalog #ES011). The specific activity is >3,000 pmol/min/μg, as measured under the described conditions.

TFPI
Recombinant Human TFPI (Catalog #2974-PI) inhibits trypsin cleavage of a fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2 (Catalog #ES002). The IC₅₀ value is <0.75 nM, as measured under the described conditions.

t-Plasminogen Activator/tPA
Recombinant Human t-Plasminogen Activator/tPA (Catalog #7449-SE) cleaves a peptide substrate, N-carbobenzyloxy-Gly-Gly-Arg-7-amido-4-methylcoumarin (Z-GGR-AMC). The specific activity is >190 pmol/min/μg, as measured under the described conditions.