Home / STING Antagonists / C 176

C 176

Catalog #: 7040
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7040/50
7040/10
C 176 | CAS No. 314054-00-7 | STING Antagonists
1 Image
Description: mSTING antagonist

Purity: ≥97%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

C 176 is a mSTING antagonist. Covalently binds Cys91 of mouse but not human STING. Blocks activation-induced palmitoylation of STING and formation of STING clusters. Reduces CMA (Cat. No. 6677) -induced increase in serum IFNs in vivo and suppresses systemic inflammation in a mouse inflammatory disease model.

Technical Data

M.Wt:
358.09
Formula:
C11H7IN2O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
314054-00-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Targeting STING with covalent small-molecule inhibitors.
    Haag et al.
    Nature, 2018;559:269

Product Datasheets

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Reconstitution Calculator

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Citation for C 176

The citations listed below are publications that use Tocris products. Selected citations for C 176 include:

1 Citation: Showing 1 - 1

  1. Innate immune signaling drives late cardiac toxicity following DNA-damaging cancer therapies.
    Authors: Kevin C Et al.
    J Exp Med  2023;220

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