Home / Active Degraders / CST 905

CST 905

Catalog #: 7745 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7745/5
CST 905 | Active Degraders
1 Image
Description: Potent and selective BRAFV600E Degrader (PROTAC®)

Chemical Name: (2S,4R)-1-((S)-2-(2-(4-(4-(3-(3-((N-Ethyl-N-methylsulfamoyl)amino)-2,6-difluorobenzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Purity: ≥98%

Product Details
Reviews
Biological Activity Technical Data Product Datasheets Calculators

Biological Activity

CST 905 is a potent and selective BRAFV600E Degrader (PROTAC®) (DC50 = 18 nM). CST 905 comprises a ligand for the von Hippel Lindau (VHL) E3 ligase joined by a linker to a PLX-derived ligand. Unlike other BRAFV600E Degraders, CST 905 does not activate ERK.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
1025.2
Formula:
C51H58F2N10O7S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for CST 905

There are currently no reviews for this product. Be the first to review CST 905 and earn rewards!

Have you used CST 905?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.