D-AP5
Chemical Name: D-(-)-2-Amino-5-phosphonopentanoic acid
Purity: ≥99%
Biological Activity
D-AP5 is a selective NMDA receptor antagonist that competes with glutamate binding and is commonly used to inhibit NMDA-dependent synaptic plasticity. D-AP5 is the more active isomer of DL-AP5 (Cat. No. 0105) and displays approximately 52-fold higher potency than the L-isomer, L-AP5 (Cat. No. 0107). In vitro D-AP5 reduces NMDA-induced depolarization of cortical neurons, with no effect on the response to L-Quisqualic acid (Cat. No. 0188) or Kainic acid (Cat. No. 0222). Following spinal injection, D-AP5 results in rapid reduction of NMDA-response but no effect on spontaneously active neurons.DL Mixture, L-isomer and sodium salt also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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The effect of a series of ω-phosphonic-α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations.
Evans et al.
Br.J.Pharmacol., 1982;75:65 -
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord.
Davies and Watkins
Brain Res., 1982;235:378 -
Utilization of the resolved L-isomer of 2-amino-6-phosphonhexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons.
Schulte et al.
Brain Res., 1994;649:203 -
Utilization of the resolved L-isomer fo 2-amino-6-phosphonohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons.
Schulte et al.
Brain Res., 1994;649:203 -
A comparison between the in vivo and in vitro activity of five potent and competitive NMDA antagonists.
Lodge et al.
Br.J.Pharmacol., 1988;95:957
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Citations for D-AP5
The citations listed below are publications that use Tocris products. Selected citations for D-AP5 include:
372 Citations: Showing 1 - 10
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Voltage-gated potassium channels ensure action potential shape fidelity in distal axons.
Authors: Sabater Et al.
J Neurosci 2021;41:5372
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Axonal mechanisms mediating γ-aminobutyric acid receptor type A (GABA-A) inhibition of striatal dopamine release.
Authors: Kramer Et al.
ELife 2020;9
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Nucleus Accumbens Tac1-Expressing Neurons Mediate Stress-Induced Anhedonia-like Behavior in Mice.
Authors: He Et al.
Cell Rep 2020;33
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Functional Dissection of Basal Ganglia Inhibitory Inputs onto Substantia Nigra Dopaminergic Neurons.
Authors: Evans Et al.
Cell Rep 2020;32
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Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner.
Authors: Dorst Et al.
Nat Comms 2020;11:5113
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The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest.
Authors: Duman Et al.
Elife 2019;8
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NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content.
Authors: Chiu Et al.
Cell Rep 2019;28:332
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Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient.
Authors: Woo Et al.
Exp Neurobiol 2019;28:30
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Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference.
Authors: Nam Et al.
Cell Rep 2019;28:1154
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Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression.
Authors: Wagner Et al.
Cell Rep 2019;28:11
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Routing Hippocampal Information Flow through Parvalbumin Interneuron Plasticity in Area CA2.
Authors: Nasrallah Et al.
Cell Rep 2019;27:86
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Transient, Consequential Increases in Extracellular Potassium Ions Accompany Channelrhodopsin2 Excitation.
Authors: Octeau Et al.
Cell Rep 2019;27:2249
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A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons.
Authors: Meijer Et al.
Cell Rep 2019;27:2199
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Kibra Modulates Learning and Memory via Binding to Dendrin.
Authors: Ji Et al.
Cell Rep 2019;26:2064
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High-Frequency Microdomain Ca2+ Transients and Waves during Early Myelin Internode Remodeling.
Authors: Battefeld Et al.
Cell Rep 2019;26:182
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Homeostatic Intrinsic Plasticity Is Functionally Altered in Fmr1 KO Cortical Neurons.
Authors: Bülow Et al.
Cell Rep 2019;26:1378
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KCC2-Mediated Cl- Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice.
Authors: Spoljaric Et al.
Cell Rep 2019;26:1073
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Role of intraganglionic transmission in the trigeminovascular pathway.
Authors: Zhang Et al.
Mol Pain 2019;15:1744806919836570
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Simultaneous voltage and calcium imaging and optogenetic stimulation with high sensitivity and a wide field of view.
Authors: Nguyen Et al.
Biomed Opt Express 2019;10:789
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Novel positive allosteric modulators of glutamate transport have neuroprotective properties in an in vitro excitotoxic model.
Authors: Falcucci Et al.
ACS Chem Neurosci 2019;10:3437
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How Gastrin-Releasing Peptide Opens the Spinal Gate for Itch.
Authors: Pagani Et al.
Neuron 2019;
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Activity-Dependent Downscaling of Subthreshold Synaptic Inputs during Slow-Wave-Sleep-like Activity In Vivo.
Authors: González-Rueda Et al.
Neuron 2018;97:1244
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DA neuron glutamate cotransmission evokes a delayed excitation in lateral dorsal striatal cholinergic interneurons.
Authors: Chuhma Et al.
Elife 2018;7
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A circuit from hippocampal CA2 to lateral septum disinhibits social aggression.
Authors: Leroy Et al.
Nature 2018;564:213
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The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity.
Authors: Filipello Et al.
Immunity 2018;48:979
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DA Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of DA and Glutamate.
Authors: Cai and Ford
Cell Rep 2018;25:3148
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Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons.
Authors: Smith Et al.
Cell Rep 2018;25:278
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Activity-Dependent Netrin-1 Secretion Drives Synaptic Insertion of GluA1-Containing AMPA Receptors in the Hippocampus.
Authors: Glasgow Et al.
Cell Rep 2018;25:168
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CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse.
Authors: Dong Et al.
Cell Rep 2018;24:284
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The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism.
Authors: Beas Et al.
Nat Neurosci 2018;21:963
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Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement.
Authors: Adamsky Et al.
Cell 2018;174:59
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All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition.
Authors: Fan Et al.
Nat Methods 2018;15:823
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(2R,6R)-hydroxynorKA rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray.
Authors: Chou Et al.
Neuropharmacology 2018;139:1
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Drebrin Isoforms Critically Regulate NMDAR- and mGluR-Dependent LTD Induction.
Authors: Yasuda Et al.
Front Cell Neurosci 2018;12:330
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Proximodistal Heterogeneity of Hippocampal CA3 Pyramidal Neuron Intrinsic Properties, Connectivity, and Reactivation during Memory Recall.
Authors: Sun Et al.
Neuron 2017;95:656
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Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus.
Authors: Medrihan Et al.
Neuron 2017;95:564
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Encoding of Discriminative Fear Memory by Input-Specific LTP in the Amygdala.
Authors: Kim and Cho
Neuron 2017;95:1129
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Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory.
Authors: Leroy Et al.
Neuron 2017;95:1089
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IGF1-Dependent Synaptic Plasticity of Mitral Cells in Olfactory Memory during Social Learning.
Authors: Liu Et al.
Neuron 2017;95:106
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A Critical Role of Presynaptic Cadherin/Catenin/p140Cap Complexes in Stabilizing Spines and Functional Synapses in the Neocortex.
Authors: Li Et al.
Neuron 2017;94:1155
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Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses.
Authors: Zhu Et al.
Nat Commun 2017;8:1676
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Differential processing of thalamic information via distinct striatal interneuron circuits.
Authors: Assous
Nat Commun 2017;8:15860
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Subtype-specific effects of DArgic D2 receptor activation on synaptic trains in layer V pyramidal neurons in the mouse prefrontal cortex.
Authors: Leyrer-Jackson
Physiol Rep 2017;5(22):e13499
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Synaptically driven phosphorylation of ribosomal protein S6 is differentially regulated at active synapses versus dendrites and cell bodies by MAPK and PI3K/mTOR signaling pathways.
Authors: Pirbhoy Et al.
Learn Mem 2017;24:341
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DA D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.
Authors: Guo
Aging Cell 2017;16(6):1323
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Toll-like receptor 4 deficiency alters nucleus accumbens synaptic physiology and drug reward behavior.
Authors: Kashima and Grueter
Proc Natl Acad Sci U S A. 2017;114(3):8865
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Nitric Oxide Is Required for L-Type Ca(2+) Channel-Dependent Long-Term Potentiation in the Hippocampus.
Authors: Pigott and Garthwaite
Front Synaptic Neurosci 2016;8:17
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Glycinergic dysfunction in a subpopulation of dorsal horn interneurons in a rat model of neuropathic pain
Authors: Imlach Et al.
Scientific Reports 2016;6:37104
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Increased GABAB receptor signaling in a rat model for schizophrenia
Authors: Selten Et al.
Scientific Reports 2016;6:34240
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Signaling mechanism for modulation by ATP of glycine receptors on rat retinal ganglion cells.
Authors: Zhang Et al.
Sci Rep 2016;6:28938
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Endocannabinoid dynamics gate spike-timing dependent depression and potentiation.
Authors: Cui Et al.
Elife 2016;5:e13185
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A cholinergic basal forebrain feeding circuit modulates appetite suppression
Authors: Herman Et al.
Nature 2016;538:253
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Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus.
Authors: Park Et al.
J Neurosci 2016;36:622
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Context-Dependent Modulation of GABAAR-Mediated Tonic Currents.
Authors: Patel Et al.
J Neurosci 2016;36:607
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Hypocretin/Orexin Peptides Alter Spike Encoding by Serotonergic Dorsal Raphe Neurons through Two Distinct Mechanisms That Increase the Late Afterhyperpolarization.
Authors: Ishibashi Et al.
J Neurosci 2016;36:10097
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Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus.
Authors: Dennis Et al.
Cereb Cortex 2016;26:414
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Synaptic activation of ribosomal protein S6 phosphorylation occurs locally in activated dendritic domains.
Authors: Pirbhoy Et al.
Learn Mem 2016;23:255
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Diminished KCC2 confounds synapse specificity of LTP during senescence.
Authors: Ferando Et al.
Nat Neurosci 2016;19:1197
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Neuronal firing patterns outweigh circuitry oscillations in parkinsonian motor control.
Authors: Pan Et al.
J Clin Invest 2016;126:4516
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Differential modulation of repetitive firing and synchronous network activity in neocortical interneurons by inhibition of A-type K(+) channels and Ih.
Authors: Williams and Hablitz
Front Cell Neurosci 2015;9:89
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Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome.
Authors: Costa Et al.
Front Behav Neurosci 2015;9:65
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NE Modulates Pyramidal Cell Synaptic Properties in the Anterior Piriform Cortex of Mice: Age-Dependent Effects of β-adrenoceptors.
Authors: Ghosh Et al.
Front Cell Neurosci 2015;9:450
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A pre-docking source for the power-law behavior of spontaneous quantal release: application to the analysis of LTP.
Authors: Lamanna Et al.
Front Cell Neurosci 2015;9:44
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Dendritic morphology, synaptic transmission, and activity of mature granule cells born following PilC-induced status epilepticus in the rat.
Authors: Gao Et al.
Front Cell Neurosci 2015;9:384
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GABAA receptor activity shapes the formation of inhibitory synapses between developing medium spiny neurons.
Authors: Arama Et al.
Front Cell Neurosci 2015;9:290
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Interaction of electrically evoked activity with intrinsic dynamics of cultured cortical networks with and without functional fast GABAergic synaptic transmission.
Authors: Baltz and Voigt
Front Cell Neurosci 2015;9:272
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Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors.
Authors: Park Et al.
Mol Brain 2015;8:7
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Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia.
Authors: Campbell Et al.
Front Cell Neurosci 2015;8:425
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Involvement of cAMP-guanine nucleotide exchange factor II in hippocampal long-term depression and behavioral flexibility.
Authors: Lee Et al.
Mol Brain 2015;8:38
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Activation of calcineurin underlies altered trafficking of α2 subunit containing GABAA receptors during prolonged epileptiform activity.
Authors: Eckel Et al.
Neuropharmacology 2015;88:82
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LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation.
Authors: Telese Et al.
Neuron 2015;86:696
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Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss.
Authors: Birnbaum Et al.
Cell Death Dis 2015;6:e1791
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Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons.
Authors: Curcio Et al.
Cell Death Dis 2015;6:e1645
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Wnt signalling tunes neurotransmitter release by directly targeting Synaptotagmin-1.
Authors: Ciani Et al.
Nat Commun 2015;6:8302
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Subventricular zone neural progenitors reverse TNF-α effects in cortical neurons.
Authors: Morini Et al.
Stem Cell Res Ther 2015;6:166
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Interactions of Human Autoantibodies with Hippocampal GABAergic Synaptic Transmission - Analyzing Antibody-Induced Effects ex vivo.
Authors: Haselmann Et al.
Front Neurol 2015;6:136
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MicroRNA miR124 is required for the expression of homeostatic synaptic plasticity.
Authors: Hou Et al.
Nat Commun 2015;6:10045
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Nitric oxide targets oligodendrocytes and promotes their morphological differentiation.
Authors: Garthwaite Et al.
Glia 2015;63:383
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GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy.
Authors: Campbell Et al.
Glia 2015;63:23
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Histone deacetylase 3 inhibition re-establishes synaptic tagging and capture in aging through the activation of nuclear factor κ B.
Authors: Sharma Et al.
Sci Rep 2015;5:16616
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Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex.
Authors: Tang Et al.
Sci Rep 2015;5:14099
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Basolateral amygdala rapid glutamate release encodes an outcome-specific representation vital for reward-predictive cues to selectively invigorate reward-seeking actions.
Authors: Malvaez Et al.
Sci Rep 2015;5:12511
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Differential inhibition onto developing and mature granule cells generates high-frequency filters with variable gain.
Authors: Pardi Et al.
Elife 2015;4:e08764
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Retroactive modulation of spike timing-dependent plasticity by DA.
Authors: Brzosko Et al.
Elife 2015;4
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AMPA receptor mediated synaptic excitation drives state-dependent bursting in Purkinje neurons of zebrafish larvae.
Authors: Sengupta and Thirumalai
Elife 2015;4
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Neuron-glia signaling in developing retina mediated by neurotransmitter spillover.
Authors: Rosa Et al.
Elife 2015;4
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Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
Authors: Gerhold Et al.
J Neurosci 2015;35:9580
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An Asymmetric Increase in Inhibitory Synapse Number Underlies the Development of a Direction Selective Circuit in the Retina.
Authors: Morrie and Feller
J Neurosci 2015;35:9281
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Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus.
Authors: Puranam Et al.
J Neurosci 2015;35:8866
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Developmental changes in synaptic distribution in arcuate nucleus neurons.
Authors: Baquero Et al.
J Neurosci 2015;35:8558
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Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways.
Authors: Zhu Et al.
J Neurosci 2015;35:621
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Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
Authors: Cramer Et al.
J Neurosci 2015;35:5664
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BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain DA neurons.
Authors: Zhong Et al.
J Neurosci 2015;35:4469
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Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinement.
Authors: Dilger Et al.
J Neurosci 2015;35:3652
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Miro1 Regulates Activity-Driven Positioning of Mitochondria within Astrocytic Processes Apposed to Synapses to Regulate Intracellular Calcium Signaling.
Authors: Stephen Et al.
J Neurosci 2015;35:15996
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Loss of Local Astrocyte Support Disrupts Action Potential Propagation and Glutamate Release Synchrony from Unmyelinated Hippocampal Axon Terminals In Vitro.
Authors: Sobieski Et al.
J Neurosci 2015;35:11105
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Afterhyperpolarization (AHP) regulates the frequency and timing of action potentials in the mitral cells of the olfactory bulb: role of olfactory experience.
Authors: Duménieu Et al.
Physiol Rep 2015;3
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Synapse-specific compartmentalization of signaling cascades for LTP induction in CA3 interneurons.
Authors: Galván Et al.
Neuroscience 2015;290:332
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Asynchronous GABA Release Is a Key Determinant of Tonic Inhibition and Controls Neuronal Excitability: A Study in the Synapsin II-/- Mouse.
Authors: Medrihan Et al.
Cereb Cortex 2015;25:3356
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Morphological and physiological evidence of a synaptic connection between the lateral parabrachial nucleus and neurons in the A7 catecholamine cell group in rats.
Authors: Liu Et al.
J Biomed Sci 2015;22:79
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Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β.
Authors: Vossel Et al.
J Cell Biol 2015;209:419
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Neuraminidase inhibition primes short-term depression and suppresses long-term potentiation of synaptic transmission in the rat hippocampus.
Authors: Savotchenko Et al.
Neural Plast 2015;2015:908190
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Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
Authors: Polito Et al.
Eneuro 2015;2
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Visual recognition memory, manifested as long-term habituation, requires synaptic plasticity in V1.
Authors: Cooke Et al.
Nat Neurosci 2015;18:262
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Functional α7 nicotinic receptors are expressed on immature granule cells of the postnatal dentate gyrus.
Authors: John Et al.
Brain Res 2015;1601:15
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The Posterodorsal Medial Amygdala Regulates the Timing of Puberty Onset in Female Rats.
Authors: Li Et al.
Endocrinology 2015;156:3725
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The rat retina has five types of ganglion-cell photoreceptors.
Authors: Reifler Et al.
Exp Eye Res 2015;130:17
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Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture.
Authors: Pasca Et al.
Nat Methods 2015;12:671
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PacT. induces acute pain via directly activating toll like receptor 4.
Authors: Yan Et al.
Mol Pain 2015;11:10
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Intrinsic excitability varies by sex in prepubertal striatal medium spiny neurons.
Authors: Dorris Et al.
J Neurophysiol 2015;113:720
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Structural elements that underlie Doc2β function during asynchronous synaptic transmission.
Authors: Xue Et al.
Proc Natl Acad Sci U S A 2015;112:E4316
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Tectal microcircuit generating visual selection commands on gaze-controlling neurons.
Authors: Kardamakis Et al.
Proc Natl Acad Sci U S A 2015;112:E1956
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ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons.
Authors: Noh Et al.
Proc Natl Acad Sci U S A 2015;112:6820
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Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38.
Authors: Toda and Huganir
Proc Natl Acad Sci U S A 2015;112:6712
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Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors.
Authors: Tseng Et al.
Proc Natl Acad Sci U S A 2015;112:1214
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Apamin Boosting of Synaptic Potentials in CaV2.3 R-Type Ca2+ Channel Null Mice.
Authors: Wang Et al.
PLoS One 2015;10:e0139332
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Chloride Accumulators NKCC1 and AE2 in Mouse GnRH Neurons: Implications for GABAA Mediated Excitation.
Authors: Taylor-Burds Et al.
PLoS One 2015;10:e0131076
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G-Protein Coupled Receptor Kinase 2 Minimally Regulates Melanopsin Activity in Intrinsically Photosensitive Retinal Ganglion Cells.
Authors: Sexton and Gelder
PLoS One 2015;10:e0128690
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The effect of Dflu. on neuronal communication at a central synapse.
Authors: Mapelli Et al.
PLoS One 2015;10:e0123534
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Kinetic evaluation of photosensitivity in bi-stable variants of chimeric channelrhodopsins.
Authors: Hososhima Et al.
PLoS One 2015;10:e0119558
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α-Actinin-2 mediates spine morphology and assembly of the post-synaptic density in hippocampal neurons.
Authors: Hodges Et al.
PLoS One 2014;9:e101770
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Inhibitory projections from the ventral nucleus of the trapezoid body to the medial nucleus of the trapezoid body in the mouse.
Authors: Albrecht Et al.
Front Neural Circuits 2014;8:83
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Electrophysiological characterization of male goldfish (Carassius auratus) ventral preoptic area neurons receiving olfactory inputs.
Authors: Lado Et al.
Front Neurosci 2014;8:185
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DA neurons control striatal cholinergic neurons via regionally heterogeneous DA and glutamate signaling.
Authors: Chuhma Et al.
Neuron 2014;81:901
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HSF1 transcriptional activity mediates alcohol induction of Vamp2 expression and GABA release.
Authors: Varodayan and Harrison
Front Integr Neurosci 2014;7:89
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Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala.
Authors: Mirante Et al.
Front Mol Neurosci 2014;7:62
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Synaptic plasticity in glutamatergic and GABAergic neurotransmission following chronic Mem. treatment in an in vitro model of limbic epileptogenesis.
Authors: He and Bausch
Neuropharmacology 2014;77:379
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Quantitative profiling of peptides from RNAs classified as noncoding.
Authors: Prabakaran Et al.
Nat Commun 2014;5:5429
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Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission.
Authors: Accardi Et al.
Nat Commun 2014;5:3168
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Long-term depression-inducing stimuli promote cleavage of the synaptic adhesion molecule NGL-3 through NMDA receptors, matrix metalloproteinases and presenilin/γ-secretase.
Authors: Lee Et al.
Philos Trans R Soc Lond B Biol Sci 2014;369:20130158
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Mutant β-III spectrin causes mGluR1α mislocalization and functional deficits in a mouse model of spinocerebellar ataxia type 5.
Authors: Armbrust Et al.
J Neurosci 2014;34:9891
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Glycolysis and oxidative phosphorylation in neurons and astrocytes during network activity in hippocampal slices.
Authors: Ivanov Et al.
J Cereb Blood Flow Metab 2014;34:397
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Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation.
Authors: Blanco-Suárez Et al.
J Cereb Blood Flow Metab 2014;34:1898
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A synaptic signature for ON- and OFF-center parasol ganglion cells of the primate retina.
Authors: Crook Et al.
Vis Neurosci 2014;31:57
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Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aβ-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: rapid reversal by anti-Aβ agents.
Authors: Qi Et al.
Acta Neuropathol Commun 2014;2:175
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Vort. disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus.
Authors: Dale Et al.
J Psychopharmacol 2014;28:891
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Mutations that disrupt Ca2+-binding activity endow Doc2β with novel functional properties during synaptic transmission.
Authors: Gaffaney Et al.
Mol Biol Cell 2014;25:481
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Accumulation of GABAergic neurons, causing a focal ambient GABA gradient, and downregulation of KCC2 are induced during microgyrus formation in a mouse model of polymicrogyria.
Authors: Wang Et al.
Cereb Cortex 2014;24:1088
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Isoliquiritigenin, a chalcone compound, enhances spontaneous inhibitory postsynaptic response.
Authors: Woo Et al.
Exp Neurobiol 2014;23:163
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Long-term potentiation can be induced in the CA1 region of hippocampus in the absence of αCaMKII T286-autophosphorylation.
Authors: Villers Et al.
Learn Mem 2014;21:616
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Munc18-1 redistributes in nerve terminals in an activity- and PKC-dependent manner.
Authors: Cijsouw Et al.
J Cell Biol 2014;204:759
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Adenomatous polyposis coli protein deletion leads to cognitive and autism-like disabilities.
Authors: Mohn Et al.
Mol Psychiatry 2014;19:1133
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CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses.
Authors: Bemben Et al.
Nat Neurosci 2014;17:56
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The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
Authors: Sánchez-Blázquez Et al.
Int J Neuropsychopharmacol 2014;17:1943
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Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 δ glutamate receptors.
Authors: Ady Et al.
EMBO Rep 2014;15:103
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NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.
Authors: Simma Et al.
Cell Commun Signal 2014;12:75
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Deranged NMDAergic cortico-subthalamic transmission underlies parkinsonian motor deficits.
Authors: Pan Et al.
J Clin Invest 2014;124:4629
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Depressed GABA and glutamate synaptic signaling by 5-HT1A receptors in the nucleus tractus solitarii and their role in cardiorespiratory function.
Authors: Ostrowski Et al.
J Neurophysiol 2014;111:2493
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Synthesis, transport, and metabolism of serotonin formed from exogenously applied 5-HTP after spinal cord injury in rats.
Authors: Li Et al.
J Neurophysiol 2014;111:145
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GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses.
Authors: Berlinguer-Palmini Et al.
PLoS One 2013;8:e82180
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Hyperactivity of ON-type retinal ganglion cells in streptozotocin-induced diabetic mice.
Authors: Yu Et al.
PLoS One 2013;8:e76049
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Region-specific integration of embryonic stem cell-derived neuronal precursors into a pre-existing neuronal circuit.
Authors: Neuser Et al.
PLoS One 2013;8:e66497
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Synaptic NMDA receptor-dependent Ca2+ entry drives membrane potential and Ca2+ oscillations in spinal ventral horn neurons.
Authors: Alpert and Alford
PLoS One 2013;8:e63154
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Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons.
Authors: Wang Et al.
PLoS One 2013;8:e61787
-
Contribution of NMDA receptor hypofunction in prefrontal and cortical excitatory neurons to schizophrenia-like phenotypes.
Authors: Rompala Et al.
PLoS One 2013;8:e61278
-
Different transporter systems regulate extracellular GABA from vesicular and non-vesicular sources.
Authors: Song Et al.
Front Cell Neurosci 2013;7:23
-
Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons.
Authors: Ferando and Mody
Front Neural Circuits 2013;7:144
-
Intersecting circuits generate precisely patterned retinal waves.
Authors: Akrouh and Kerschensteiner
Neuron 2013;79:322
-
HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity.
Authors: Vicente-Sánchez Et al.
Mol Brain 2013;6:42
-
Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS.
Authors: Koeglsperger Et al.
Glia 2013;61:985
-
Postsynaptic protein synthesis is required for presynaptic enhancement in persistent forms of long-term potentiation.
Authors: Johnstone and Raymond
Front Synaptic Neurosci 2013;5:1
-
Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.
Authors: Bernard Et al.
Neurobiol Dis 2013;59:42736
-
Cortical interneurons that specialize in disinhibitory control.
Authors: Pi Et al.
Nature 2013;503:521
-
Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels.
Authors: Medrihan Et al.
Nat Commun 2013;4:1512
-
Ghrelin increases GABAergic transmission and interacts with ethanol actions in the rat central nucleus of the amygdala.
Authors: Cruz Et al.
Neuropsychopharmacology 2013;38:364
-
Modulation of mGluR-dependent MAP1B translation and AMPA receptor endocytosis by microRNA miR-146a-5p.
Authors: Chen and Shen
J Neurosci 2013;33:9013
-
A Myosin Va mutant mouse with disruptions in glutamate synaptic development and mature plasticity in visual cortex.
Authors: Yoshii Et al.
J Neurosci 2013;33:8472
-
The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.
Authors: Chen Et al.
J Neurosci 2013;33:8336
-
Hypothalamic neurotensin projections promote reward by enhancing glutamate transmission in the VTA.
Authors: Kempadoo Et al.
J Neurosci 2013;33:7618
-
Axonal translation of β-catenin regulates synaptic vesicle dynamics.
Authors: Taylor Et al.
J Neurosci 2013;33:5584
-
PrPC controls via protein kinase A the direction of synaptic plasticity in the immature hippocampus.
Authors: Caiati Et al.
J Neurosci 2013;33:2973
-
Ovarian hormone loss impairs excitatory synaptic transmission at hippocampal CA3-CA1 synapses.
Authors: Wu Et al.
J Neurosci 2013;33:16158
-
TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors.
Authors: Pribiag and Stellwagen
J Neurosci 2013;33:15879
-
An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling.
Authors: Siddoway Et al.
J Neurosci 2013;33:11206
-
Locally-generated Acetaldehyde Contributes to the Effects of Ethanol on Neurosteroids and LTP in the Hippocampus.
Authors: Tokuda Et al.
Neurol Clin Neurosci 2013;1:138
-
Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity.
Authors: Korb Et al.
Nat Neurosci 2013;16:874
-
Regulation of ERK1/2 mitogen-activated protein kinase by NMDA-receptor-induced seizure activity in cortical slices.
Authors: Yamagata Et al.
Brain Res 2013;1507:1
-
Fast neurotransmitter release regulated by the endocytic scaffold intersectin.
Authors: Sakaba Et al.
Proc Natl Acad Sci U S A 2013;110:8266
-
Long-term potentiation of synaptic transmission in the adult mouse insular cortex: multielectrode array recordings.
Authors: Liu Et al.
J Neurophysiol 2013;110:505
-
Long-lasting LTP requires neither repeated trains for its induction nor protein synthesis for its development.
Authors: Villers Et al.
PLoS One 2012;7:e40823
-
Striatal DA transmission is subtly modified in human A53Tα-synuclein overexpressing mice.
Authors: Platt Et al.
PLoS One 2012;7:e36397
-
Olfactory bulb glomerular NMDA receptors mediate olfactory nerve potentiation and odor preference learning in the neonate rat.
Authors: Lethbridge Et al.
PLoS One 2012;7:e35024
-
Opposing Effects of Intrinsic Conductance and Correlated Synaptic Input on V-Fluctuations during Network Activity.
Authors: Kolind Et al.
Front Comput Neurosci 2012;6:40
-
Human glioma cells induce hyperexcitability in cortical networks.
Authors: Campbell Et al.
Epilepsia 2012;53:1360
-
Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.
Authors: Udagawa Et al.
Mol Cell 2012;47:253
-
The mu-opioid receptor and the NMDA receptor associate in PAG neurons: implications in pain control.
Authors: Rodríguez-Muñoz Et al.
Neuropsychopharmacology 2012;37:338
-
Increased Kv1 channel expression may contribute to decreased sIPSC frequency following chronic inhibition of NR2B-containing NMDAR.
Authors: He Et al.
Neuropsychopharmacology 2012;37:1338
-
The role of inhibition in oscillatory wave dynamics in the cortex.
Authors: Xiao Et al.
Eur J Neurosci 2012;36:2201
-
DArgic modulation of ganglion-cell photoreceptors in rat.
Authors: Hook Et al.
Eur J Neurosci 2012;35:507
-
Tissue engineering the monosynaptic circuit of the stretch reflex arc with co-culture of embryonic motoneurons and proprioceptive sensory neurons.
Authors: Guo Et al.
Biomaterials 2012;33:5723
-
Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors.
Authors: Fortin Et al.
J Neurosci 2012;32:8127
-
Calcium-dependent but action potential-independent BCM-like metaplasticity in the hippocampus.
Authors: Hulme Et al.
J Neurosci 2012;32:6785
-
GABA is excitatory in adult vasopressinergic neuroendocrine cells.
Authors: Haam Et al.
J Neurosci 2012;32:572
-
The mode of retinal presynaptic inhibition switches with light intensity.
Authors: Ichinose and Lukasiewicz
J Neurosci 2012;32:4360
-
Parasynaptic NMDA receptor signaling couples neuronal glutamate transporter function to AMPA receptor synaptic distribution and stability.
Authors: Jarzylo and Man
J Neurosci 2012;32:2552
-
Neuregulin directly decreases voltage-gated sodium current in hippocampal ErbB4-expressing interneurons.
Authors: Janssen Et al.
J Neurosci 2012;32:13889
-
Astrocyte-derived thrombospondins mediate the development of hippocampal presynaptic plasticity in vitro.
Authors: Crawford Et al.
J Neurosci 2012;32:13100
-
Repeated stress dysregulates κ-opioid receptor signaling in the dorsal raphe through a p38α MAPK-dependent mechanism.
Authors: Lemos Et al.
J Neurosci 2012;32:12325
-
Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity.
Authors: Gaamouch Et al.
J Neurosci 2012;32:10767
-
Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current.
Authors: Saliba Et al.
EMBO J 2012;31:2937
-
Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
Authors: Caiati Et al.
Sci Rep 2012;2:285
-
NMDA receptors and BAX are essential for Aβ impairment of LTP.
Authors: Olsen and Sheng
Sci Rep 2012;2:225
-
Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala.
Authors: Daftary Et al.
Neuroscience 2012;224:125
-
Munc13 controls the location and efficiency of dense-core vesicle release in neurons.
Authors: Bospoort Et al.
J Cell Biol 2012;199:883
-
Receptor subtype-dependent galanin actions on gamma-aminobutyric acidergic neurotransmission and ethanol responses in the central amygdala.
Authors: Bajo Et al.
Addict Biol 2012;17:694
-
K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study.
Authors: Heinrich Et al.
Br J Pharmacol 2012;167:1003
-
Uncoupling the roles of synaptotagmin I during endo- and exocytosis of synaptic vesicles.
Authors: Yao Et al.
Nat Neurosci 2012;15:243
-
Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid β-protein oligomers.
Authors: Tang Et al.
Traffic 2012;13:681
-
Altered neurotransmitter release, vesicle recycling and presynaptic structure in the PilC model of temporal lobe epilepsy.
Authors: Upreti Et al.
Brain 2012;135:869
-
Astrocytes mediate in vivo cholinergic-induced synaptic plasticity.
Authors: Navarrete Et al.
PLoS Biol 2012;10:e1001259
-
Age-dependent effect of hearing loss on cortical inhibitory synapse function.
Authors: Takesian Et al.
J Neurophysiol 2012;107:937
-
Effect of prolonged R.zole exposure on cultured motoneurons in a mouse model of ALS.
Authors: Schuster Et al.
J Neurophysiol 2012;107:484
-
A critical role for GluN2B-containing NMDA receptors in cortical development and function.
Authors: Wang Et al.
Neuron 2011;72:789
-
Development of NMDA NR2 subunits and their roles in critical period maturation of neocortical GABAergic interneurons.
Authors: Zhang and Sun
Dev Neurobiol 2011;71:221
-
Functional refinement in the projection from ventral cochlear nucleus to lateral superior olive precedes hearing onset in rat.
Authors: Case Et al.
PLoS One 2011;6:e20756
-
Sleep-deprivation regulates α-2 adrenergic responses of rat hypocretin/orexin neurons.
Authors: Uschakov Et al.
PLoS One 2011;6:e16672
-
11-Deoxycortisol impedes GABAergic neurotransmission and induces drug-resistant status epilepticus in mice.
Authors: Kaminski Et al.
Neuropharmacology 2011;60:1098
-
Fast oscillatory activity induced by kainate receptor activation in the rat basolateral amygdala in vitro.
Authors: Randall Et al.
Eur J Neurosci 2011;33:914
-
Calcium-independent inhibitory G-protein signaling induces persistent presynaptic muting of hippocampal synapses.
Authors: Crawford Et al.
J Neurosci 2011;31:979
-
Loss of Tsc1 in vivo impairs hippocampal mGluR-LTD and increases excitatory synaptic function.
Authors: Bateup Et al.
J Neurosci 2011;31:8862
-
Molecular determinants controlling NMDA receptor synaptic incorporation.
Authors: Storey Et al.
J Neurosci 2011;31:6311
-
Delayed postnatal loss of P/Q-type calcium channels recapitulates the absence epilepsy, dyskinesia, and ataxia phenotypes of genomic Cacna1a mutations.
Authors: Mark Et al.
J Neurosci 2011;31:4311
-
Ovarian hormone deficiency reduces intrinsic excitability and abolishes acute estrogen sensitivity in hippocampal CA1 pyramidal neurons.
Authors: Wu Et al.
J Neurosci 2011;31:2638
-
Attenuating GABA(A) receptor signaling in DA neurons selectively enhances reward learning and alters risk preference in mice.
Authors: Parker Et al.
J Neurosci 2011;31:17103
-
Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice.
Authors: Pan Et al.
J Neurosci 2011;31:13420
-
Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing.
Authors: Lazarevic Et al.
J Neurosci 2011;31:10189
-
An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus.
Authors: Etherton Et al.
EMBO J 2011;30:2908
-
Rapid developmental maturation of neocortical FS cell intrinsic excitability.
Authors: Goldberg Et al.
Cereb Cortex 2011;21:666
-
Exposure of neurons to excitotoxic levels of glutamate induces cleavage of the RNA editing enzyme, adenosine deaminase acting on RNA 2, and loss of GLUR2 editing.
Authors: Mahajan Et al.
Neuroscience 2011;189:305
-
Developmental maturation of excitation and inhibition balance in principal neurons across four layers of somatosensory cortex.
Authors: Zhang Et al.
Neuroscience 2011;174:45931
-
Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1.
Authors: Straub Et al.
Nat Neurosci 2011;14:866
-
Ca(2+)-dependent enhancement of release by subthreshold somatic depolarization.
Authors: Christie Et al.
Nat Neurosci 2011;14:62
-
Suppression of PKR promotes network excitability and enhanced cognition by IF.-γ-mediated disinhibition.
Authors: Zhu Et al.
Cell 2011;147:1384
-
Hyperglycemia magnifies Schwann cell dysfunction and cell death triggered by PA-induced lipotoxicity.
Authors: Padilla Et al.
Brain Res 2011;1370:64
-
β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
Authors: Meitzen Et al.
J Neurochem 2011;116:984
-
PKCγ is required for ethanol-induced increases in GABA(A) receptor α4 subunit expression in cultured cerebral cortical neurons.
Authors: Werner Et al.
J Neurochem 2011;116:554
-
Regulation of synaptic stability by AMPA receptor reverse signaling.
Authors: Ripley Et al.
Proc Natl Acad Sci U S A 2011;108:367
-
Inhibitory-excitatory synaptic balance is shifted toward increased excitation in magnocellular neurosecretory cells of heart failure rats.
Authors: Potapenko Et al.
J Neurophysiol 2011;106:1545
-
A new mechanism for antiepileptic drug action: vesicular entry may mediate the effects of LeveT.
Authors: Meehan Et al.
J Neurophysiol 2011;106:1227
-
Network hyperexcitability in hippocampal slices from Mecp2 mutant mice revealed by voltage-sensitive dye imaging.
Authors: Calfa Et al.
J Neurophysiol 2011;105:1768
-
CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1.
Authors: Ali
J Neurophysiol 2011;105:1051
-
Systematic heterogeneity of fractional vesicle pool sizes and release rates of hippocampal synapses.
Authors: Welzel Et al.
Biophys J 2011;100:593
-
An excitatory loop with astrocytes contributes to drive neurons to seizure threshold.
Authors: Gómez-Gonzalo Et al.
PLoS Biol 2010;8:e1000352
-
SV2 mediates entry of tetanus neurotoxin into central neurons.
Authors: Yeh Et al.
PLoS Pathog 2010;6:e1001207
-
Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels.
Authors: Buchanan Et al.
Neuron 2010;68:948
-
Neurexin-neuroligin cell adhesion complexes contribute to synaptotropic dendritogenesis via growth stabilization mechanisms in vivo.
Authors: Chen Et al.
Neuron 2010;67:967
-
Melatonin potentiates glycine currents through a PLC/PKC signalling pathway in rat retinal ganglion cells.
Authors: Zhao Et al.
J Physiol 2010;588:2605
-
Tuberoinfundibular peptide of 39 residues modulates the mouse hypothalamic-pituitary-adrenal axis via paraventricular glutamatergic neurons.
Authors: Dimitrov and Usdin
J Comp Neurol 2010;518:4375
-
High-Pass Filtering and Dynamic Gain Regulation Enhance Vertical Bursts Transmission along the Mossy Fiber Pathway of Cerebellum.
Authors: Mapelli Et al.
Front Cell Neurosci 2010;4:14
-
MEF-2 regulates activity-dependent spine loss in striatopallidal medium spiny neurons.
Authors: Tian Et al.
Mol Cell Neurosci 2010;44:94
-
Different relationship of N- and P/Q-type Ca2+ channels to channel-interacting slots in controlling neurotransmission at cultured hippocampal synapses.
Authors: Cao and Tsien
J Neurosci 2010;30:4536
-
Leptin regulates AMPA receptor trafficking via PTEN inhibition.
Authors: Moult Et al.
J Neurosci 2010;30:4088
-
Ubiquitination acutely regulates presynaptic neurotransmitter release in mammalian neurons.
Authors: Rinetti and Schweizer
J Neurosci 2010;30:3157
-
DA-dependent tuning of striatal inhibitory synaptogenesis.
Authors: Goffin Et al.
J Neurosci 2010;30:2935
-
Critical involvement of postsynaptic protein kinase activation in long-term potentiation at hippocampal mossy fiber synapses on CA3 interneurons.
Authors: Galván Et al.
J Neurosci 2010;30:2844
-
Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression.
Authors: Citri Et al.
J Neurosci 2010;30:16437
-
Dysregulation of presynaptic calcium and synaptic plasticity in a mouse model of 22q11 deletion syndrome.
Authors: Earls Et al.
J Neurosci 2010;30:15843
-
A p38 mitogen-activated protein kinase-dependent mechanism of disinhibition in spinal synaptic transmission induced by tumor necrosis factor-alpha.
Authors: Zhang Et al.
J Neurosci 2010;30:12844
-
Cannabinoids excite circadian clock neurons.
Authors: Acuna-Goycolea Et al.
J Neurosci 2010;30:10061
-
Rapid activation of dormant presynaptic terminals by phorbol esters.
Authors: Chang Et al.
J Neurosci 2010;30:10048
-
Contribution of the d-Serine-Dependent Pathway to the Cellular Mechanisms Underlying Cognitive Aging.
Authors: Potier Et al.
Front Aging Neurosci 2010;2:1
-
Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation.
Authors: Maier Et al.
J Biol Chem 2010;285:35606
-
Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex.
Authors: Huang and Hsu
Cereb Cortex 2010;20:982
-
Frequency facilitation at mossy fiber-CA3 synapses of freely behaving rats contributes to the induction of persistent LTD via an adenosine-A1 receptor-regulated mechanism.
Authors: Hagena and Manahan-Vaughan
Cereb Cortex 2010;20:1121
-
Non-cell-autonomous factor induces the transition from excitatory to inhibitory GABA signaling in retina independent of activity.
Authors: Barkis Et al.
Proc Natl Acad Sci U S A 2010;107:22302
-
Constitutively active H-ras accelerates multiple forms of plasticity in developing visual cortex.
Authors: Kaneko Et al.
Proc Natl Acad Sci U S A 2010;107:19026
-
Dynamic modulation of phasic and asynchronous glutamate release in hippocampal synapses.
Authors: Chang
J Neurophysiol 2010;103:392
-
Combinatorial responses controlled by synaptic inhibition in the cerebellum granular layer.
Authors: Mapelli Et al.
J Neurophysiol 2010;103:250
-
Characterization of engineered channelrhodopsin variants with improved properties and kinetics.
Authors: Lin Et al.
Biophys J 2009;96:1803
-
Synaptotagmin has an essential function in synaptic vesicle positioning for synchronous release in addition to its role as a calcium sensor.
Authors: Young and Neher
Neuron 2009;63:482
-
Mutation of the protein kinase C site in borna disease virus phosphoprotein abrogates viral interference with neuronal signaling and restores normal synaptic activity.
Authors: Prat Et al.
PLoS Pathog 2009;5:e1000425
-
NMDA receptor-mediated long-term alterations in epileptiform activity in experimental chronic epilepsy.
Authors: Hellier Et al.
Neuropharmacology 2009;56:414
-
ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function.
Authors: Dargan Et al.
Neuropharmacology 2009;56:121
-
Transmission efficacy and plasticity in glutamatergic synapses formed by excitatory interneurons of the substantia gelatinosa in the rat spinal cord.
Authors: Santos Et al.
PLoS One 2009;4:e8047
-
ATP-dependent infra-slow (0.1 Hz) oscillations in thalamic networks.
Authors: Lörincz Et al.
PLoS One 2009;4:e4447
-
Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling.
Authors: Pan Et al.
J Pharmacol Exp Ther 2009;331:591
-
N-MthD.-aspartate receptor- and metabotropic glutamate receptor-dependent long-term depression are differentially regulated by the ubiquitin-proteasome system.
Authors: Citri Et al.
Eur J Neurosci 2009;30:1443
-
Synaptic NR2A- but not NR2B-Containing NMDA Receptors Increase with Blockade of Ionotropic Glutamate Receptors.
Authors: Engelhardt Et al.
Front Mol Neurosci 2009;2:19
-
Millisecond timescale disinhibition mediates fast information transmission through an avian basal ganglia loop.
Authors: Leblois Et al.
J Neurosci 2009;29:15420
-
The serum response factor and a putative novel transcription factor regulate expression of the immediate-early gene Arc/Arg3.1 in neurons.
Authors: Pintchovski Et al.
J Neurosci 2009;29:1525
-
Novel repression of Kcc2 transcription by REST-RE-1 controls developmental switch in neuronal chloride.
Authors: Yeo Et al.
J Neurosci 2009;29:14652
-
Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity.
Authors: Kramár Et al.
J Neurosci 2009;29:12982
-
Non-Hebbian synaptic plasticity induced by repetitive postsynaptic action potentials.
Authors: Kato Et al.
J Neurosci 2009;29:11153
-
Novel translational control in Arc-dependent long term potentiation consolidation in vivo.
Authors: Panja Et al.
J Biol Chem 2009;284:31498
-
PICK1-mediated glutamate receptor subunit 2 (GluR2) trafficking contributes to cell death in oxygen/glucose-deprived hippocampal neurons.
Authors: Dixon Et al.
J Biol Chem 2009;284:14230
-
Chronic CXCL10 alters neuronal properties in rat hippocampal culture.
Authors: Cho Et al.
J Neuroimmunol 2009;207:92
-
Functional expression of nicotinic acetylcholine receptors in rat neocortical layer 5 pyramidal cells.
Authors: Zolles Et al.
Cereb Cortex 2009;19:1079
-
DA neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection.
Authors: Chuhma Et al.
Neuroscience 2009;164:1068
-
Pathological alterations in GABAergic interneurons and reduced tonic inhibition in the basolateral amygdala during epileptogenesis.
Authors: Fritsch Et al.
Neuroscience 2009;163:415
-
Age- and gender-related differences in GABAA receptor-mediated postsynaptic currents in GABAergic neurons of the substantia nigra reticulata in the rat.
Authors: Chudomel Et al.
Neuroscience 2009;163:155
-
Early and late contributions of glutamate and CGRP to mechanical sensitization by endothelin-1.
Authors: Khodorova Et al.
J Pain 2009;10:740
-
Experience-dependent intrinsic plasticity in interneurons of barrel cortex layer IV.
Authors: Sun
J Neurophysiol 2009;102:2955
-
Activity-dependent modulation of glutamatergic signaling in the developing rat dorsal horn by early tissue injury.
Authors: Li Et al.
J Neurophysiol 2009;102:2208
-
Rapid and sensitive mapping of long-range connections in vitro using flavoprotein autofluorescence imaging combined with laser photostimulation.
Authors: Llano Et al.
J Neurophysiol 2009;101:3325
-
Stress-induced changes in nucleus accumbens glutamate synaptic plasticity.
Authors: Campioni Et al.
J Neurophysiol 2009;101:3192
-
GABA actions in hippocampal area CA3 during postnatal development: differential shift from depolarizing to hyperpolarizing in somatic and dendritic compartments.
Authors: Romo-Parra Et al.
J Neurophysiol 2008;99:1523
-
Neuropeptide S-mediated control of fear expression and extinction: role of intercalated GABAergic neurons in the amygdala.
Authors: Jüngling Et al.
Neuron 2008;59:298
-
Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation.
Authors: Kim and Tsien
Neuron 2008;58:925
-
Low expression of Kv7/M channels facilitates intrinsic and network bursting in the developing rat hippocampus.
Authors: Safiulina Et al.
J Physiol 2008;586:5437
-
TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons.
Authors: Gibson Et al.
Neuron 2008;57:746
-
Cholecystokinin inhibits endocannabinoid-sensitive hippocampal IPSPs and stimulates others.
Authors: Karson Et al.
Neuropharmacology 2008;54:117
-
Feeding induced by cannabinoids is mediated independently of the melanocortin system.
Authors: Sinnayah Et al.
PLoS One 2008;3:e2202
-
Recruitment of calcium-permeable AMPA receptors during synaptic potentiation is regulated by CaM-kinase I.
Authors: Guire Et al.
J Neurosci 2008;28:6000
-
Deficits in phosphorylation of GABA(A) receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus.
Authors: Terunuma Et al.
J Neurosci 2008;28:376
-
Activity-induced synaptic capture and exocytosis of the neuronal serine protease neurotrypsin.
Authors: Frischknecht Et al.
J Neurosci 2008;28:1568
-
Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand.
Authors: Soriano Et al.
J Neurosci 2008;28:10696
-
Kinase networks integrate profiles of N-MthD.-aspartate receptor-mediated gene expression in hippocampus.
Authors: Coba Et al.
J Biol Chem 2008;283:34101
-
Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.
Authors: Léveillé Et al.
FASEB J 2008;22:4258
-
IF.- γ directly induces neurotoxicity through a neuron specific, calcium-permeable complex of IFN- γ receptor and AMPA GluR1 receptor.
Authors: Mizuno Et al.
FASEB J 2008;22:1797
-
The chemokine CCL2 activates p38 mitogen-activated protein kinase pathway in cultured rat hippocampal cells.
Authors: Cho and Gruol
J Neuroimmunol 2008;199:94
-
An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP.
Authors: Wayman Et al.
Proc Natl Acad Sci U S A 2008;105:9093
-
Activity-dependent phosphorylation of Ser187 is required for SNAP-25-negative modulation of neuronal voltage-gated calcium channels.
Authors: Pozzi Et al.
Proc Natl Acad Sci U S A 2008;105:323
-
Endocytosis and recycling of AMPA receptors lacking GluR2/3.
Authors: Biou Et al.
Proc Natl Acad Sci U S A 2008;105:1038
-
Increased thalamocortical synaptic response and decreased layer IV innervation in GAP-43 knockout mice.
Authors: Albright Et al.
J Neurophysiol 2007;98:1610
-
Muscarinic receptor activation elicits sustained, recurring depolarizations in reticulospinal neurons.
Authors: Smetana Et al.
J Neurophysiol 2007;97:3181
-
TARP subtypes differentially and dose-dependently control synaptic AMPA receptor gating.
Authors: Milstein Et al.
Neuron 2007;55:905
-
N-arachidonoyl-DA tunes synaptic transmission onto DArgic neurons by activating both cannabinoid and vanilloid receptors.
Authors: Marinelli Et al.
Neuropsychopharmacology 2007;32:298
-
Axon and dendrite geography predict the specificity of synaptic connections in a functioning spinal cord network.
Authors: Li Et al.
Neural Dev 2007;2:17
-
Compartment-specific modulation of GABAergic synaptic transmission by μ-opioid receptor in the mouse striatum with green fluorescent protein-expressing DA islands.
Authors: Miura Et al.
J Neurosci 2007;27:9721
-
Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticus.
Authors: Kirschstein Et al.
J Neurosci 2007;27:7696
-
New transmembrane AMPA receptor regulatory protein isoform, γ-7, differentially regulates AMPA receptors.
Authors: Kato Et al.
J Neurosci 2007;27:4969
-
Synaptic scaffolding molecule alpha is a scaffold to mediate N-MthD.-aspartate receptor-dependent RhoA activation in dendrites.
Authors: Iida Et al.
Mol Cell Biol 2007;27:4388
-
Lack of synapsin I reduces the readily releasable pool of synaptic vesicles at central inhibitory synapses.
Authors: Baldelli Et al.
J Neurosci 2007;27:13520
-
Disynaptic amplification of metabotropic glutamate receptor 1 responses in the olfactory bulb.
Authors: Jan and Westbrook
J Neurosci 2007;27:132
-
Somatodendritic release of glutamate regulates synaptic inhibition in cerebellar Purkinje cells via autocrine mGluR1 activation.
Authors: Duguid Et al.
J Neurosci 2007;27:12464
-
Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices.
Authors: Fukunaga Et al.
Br J Pharmacol 2007;151:870
-
A form of perforant path LTP can occur without ERK1/2 phosphorylation or immediate early gene induction.
Authors: Steward Et al.
Learn Mem 2007;14:433
-
Synapse specificity of long-term potentiation breaks down with aging.
Authors: Ris and Godaux
Learn Mem 2007;14:185
-
Amyloid precursor protein overexpression depresses excitatory transmission through both presynaptic and postsynaptic mechanisms.
Authors: Ting Et al.
Proc Natl Acad Sci U S A 2007;104:353
-
Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors.
Authors: Nakamoto Et al.
Proc Natl Acad Sci U S A 2007;104:15537
-
A role in learning for SRF: deletion in the adult forebrain disrupts LTD and the formation of an immediate memory of a novel context.
Authors: Etkin Et al.
Neuron 2006;50:127
-
Chronic ethanol exposure and protracted abstinence alter NMDA receptors in central amygdala.
Authors: Roberto Et al.
Neuropsychopharmacology 2006;31:988
-
Differential control of postsynaptic density scaffolds via actin-dependent and -independent mechanisms.
Authors: Kuriu Et al.
J Neurosci 2006;26:7693
-
Glutamatergic Control of Microvascular Tone by Distinct GABA Neurons in the Cerebellum.
Authors: Rancillac Et al.
J Neurosci 2006;26:6997
-
Mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth.
Authors: Masson Et al.
J Neurosci 2006;26:4660
-
Barrel map development relies on protein kinase A regulatory subunit II beta-mediated cAMP signaling.
Authors: Inan Et al.
J Neurosci 2006;26:4338
-
Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.
Authors: Bender Et al.
J Neurosci 2006;26:4166
-
cAMP-dependent protein kinase postsynaptic localization regulated by NMDA receptor activation through translocation of an A-kinase anchoring protein scaffold protein.
Authors: Smith Et al.
J Neurosci 2006;26:2391
-
Differential reelin-induced enhancement of NMDA and AMPA receptor activity in the adult hippocampus.
Authors: Qiu Et al.
J Neurosci 2006;26:12943
-
NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity.
Authors: Nakazawa Et al.
EMBO J 2006;25:2867
-
Hydrogen sulfide is a novel prosecretory neuromodulator in the Guinea-pig and human colon.
Authors: Schicho Et al.
Gastroenterology 2006;131:1542
-
Evidence for low GluR2 AMPA receptor subunit expression at synapses in the rat basolateral amygdala.
Authors: Gryder Et al.
J Neurochem 2005;94:1728
-
Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.
Authors: Cirrito Et al.
Neuron 2005;48:913
-
Adaptation to synaptic inactivity in hippocampal neurons.
Authors: Thiagarajan Et al.
Neuron 2005;47:725
-
Neuromodulation via conditional release of endocannabinoids in the spinal locomotor network.
Authors: Kettunen Et al.
Neuron 2005;45:95
-
The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus.
Authors: Banko Et al.
J Neurosci 2005;25:9581
-
Strong effects of subphysiological temperature on the function and plasticity of mammalian presynaptic terminals.
Authors: Micheva and Smith
J Neurosci 2005;25:7481
-
Lack of NMDA receptor subtype selectivity for hippocampal long-term potentiation.
Authors: Berberich Et al.
J Neurosci 2005;25:6907
-
Reelin, very-low-density lipoprotein receptor, and apolipoprotein E receptor 2 control somatic NMDA receptor composition during hippocampal maturation in vitro.
Authors: Sinagra Et al.
J Neurosci 2005;25:6127
-
Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake.
Authors: Yang Et al.
J Neurosci 2005;25:4288
-
PropF. suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels.
Authors: Ying and Goldstein
Mol Pain 2005;1:2
-
Opioid-like actions of neuropeptide Y in rat substantia gelatinosa: Y1 suppression of inhibition and Y2 suppression of excitation.
Authors: Moran Et al.
J Neurophysiol 2004;92:3266
-
Endocannabinoid-mediated metaplasticity in the hippocampus.
Authors: Chevaleyre and Castillo
Neuron 2004;43:871
-
Glucose but not lactate in combination with acidosis aggravates ischemic neuronal death in vitro.
Authors: Cronberg Et al.
Stroke 2004;35:753
-
Activity-dependent expression of inositol 1,4,5-trisphosphate receptor type 1 in hippocampal neurons.
Authors: Cai Et al.
J Biol Chem 2004;279:23691
-
Tonotopic gradients of membrane and synaptic properties for neurons of the chicken nucleus magnocellularis.
Authors: Fukui and Ohmori
J Neurosci 2004;24:7514
-
Extracellular signal-regulated protein kinase activation is required for metabotropic glutamate receptor-dependent long-term depression in hippocampal area CA1.
Authors: Gallagher Et al.
J Neurosci 2004;24:4859
-
Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk.
Authors: Piet Et al.
Proc Natl Acad Sci U S A 2004;101:2151
-
Modulation of mitochondrial function by endogenous Zn2+ pools.
Authors: Sensi Et al.
Proc Natl Acad Sci U S A 2003;100:6157
-
Separable features of visual cortical plasticity revealed by N-MthD.-aspartate receptor 2A signaling.
Authors: Fagiolini Et al.
Proc Natl Acad Sci U S A 2003;100:2854
-
Bidirectional synaptic plasticity in the cerebellum-like mammalian dorsal cochlear nucleus.
Authors: Fujino and Oertel
Proc Natl Acad Sci U S A 2003;100:265
-
Altered synaptic plasticity in a mouse model of fragile X mental retardation.
Authors: Huber Et al.
Proc Natl Acad Sci U S A 2002;99:7746
-
Development of a human neuronal cell model for human immunodeficiency virus (HIV)-infected macrophage-induced neurotoxicity: apoptosis induced by HIV type 1 primary isolates and evidence for involvement of the Bcl-2/Bcl-xL-sensitive intrinsic apoptosis pa
Authors: Chen Et al.
J Virol 2002;76:9407
-
The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders.
Authors: Andrieux Et al.
Genes Dev 2002;16:2350
-
Presynaptic N-MthD.-aspartate receptors at the parallel fiber-Purkinje cell synapse.
Authors: Casado Et al.
Proc Natl Acad Sci U S A 2000;97:11593
-
A novel positive allosteric modulator of the GABA(A) receptor: the action of (+)-ROD188.
Authors: Thomet Et al.
Br J Pharmacol 2000;131:843
-
Histamine depolarizes cholinergic interneurones in the rat striatum via a H(1)-receptor mediated action.
Authors: Bell Et al.
Br J Pharmacol 2000;131:1135
-
Glutamate and gamma-aminobutyric acid mediate a heterosynaptic depression at mossy fiber synapses in the hippocampus.
Authors: Vogt and Nicoll
Proc Natl Acad Sci U S A 1999;96:1118
-
Calcium dynamics in single spines during coincident pre- and postsynaptic activity depend on relative timing of back-propagating action potentials and subthreshold excitatory postsynaptic potentials.
Authors: Koester and Sakmann
Proc Natl Acad Sci U S A 1998;95:9596
-
Glutamate receptor blockade at cortical synapses disrupts development of thalamocortical and columnar organization in somatosensory cortex.
Authors: Fox Et al.
Proc Natl Acad Sci U S A 1996;93:5584
-
Mice deficient for prion protein exhibit normal neuronal excitability and synaptic transmission in the hippocampus.
Authors: Lledo Et al.
Proc Natl Acad Sci U S A 1996;93:2403
-
Refinement of odor molecule tuning by dendrodendritic synaptic inhibition in the olfactory bulb.
Authors: Yokoi Et al.
Proc Natl Acad Sci U S A 1995;92:3371
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