Human HMGB1/HMG-1 (NP_002119.1) VersaClone cDNA

Human HMGB1/HMG-1 (NP_002119.1) VersaClone cDNA Summary

Specifications

Product Datasheets

Background: HMGB1/HMG-1

HMGB1 (high-mobility group box 1 protein), also known as HMG1 or Amphoterin, is an intracellular protein that is regulated by multiple posttranslational modifications including acetylation, phosphorylation, and methylation. HMGB1 is released upon cell necrosis, apoptosis, and pyroptosis. It acts as a multifunctional alarmin that stimulates inflammation upon sterile or infectious insult. Receptors for HMGB1 include TLR2, TLR4, TLR9, Syndecan-3, Siglec-10, Integrin alpha M beta 2, CXCR4, TIM-3, and RAGE. It is implicated in the pathogenesis of a broad range of diseases including atherosclerosis, sepsis, cancer, neurodegenerative diseases, and autoimmunity.

Related Research Areas

• Cancer Stem Cell Transcription Factors
• Hematopoietic Stem Cell Transcription Factors and Regulators
• High Mobility Group (HMG) Transcription Factors
• Microglia Activation
• Search Immune Checkpoint Targets
• Transcription Factors and Regulators
• Transcription Factors in the Akt Pathway