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JPS036

Catalog #: 8085 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8085/5
JPS036 | CAS No. 2669785-85-5 | Active Degraders
1 Image
Description: Selective HDAC3 Degrader (PROTAC®)

Chemical Name: (2S,4R)-N-[2-[[12-[[4-[(2-Aminophenyl)carbamoyl]phenyl]amino]-12-oxododecyl]oxy]-4-(4-methylthiazol-5-yl)benzyl]-1-[(S)-2-(1-fluorocyclopropan-1-ylcarbonylamino)-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxamide

Purity: ≥98%

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Biological Activity Technical Data Additional Information Product Datasheets Calculators

Biological Activity

JPS036 is a selective HDAC3 Degrader (PROTAC®) (DC50 = 440 nM; Dmax = 77 %). JPS036 comprises a benzamide-based compound joined by a linker to a Von Hippel Lindau (VHL) E3 ligase ligand.

Negative control JPS016NC also available.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
940.19
Formula:
C51H66FN7O7S
Solubility:
Soluble to 20 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2669785-85-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from the University of Leicester

Product Datasheets

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