LDV FITC
Purity: ≥90%
Biological Activity
LDV FITC is a fluorescent ligand that binds to the α4β1 integrin (VLA-4) with high affinity (Kd values are 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn2+ respectively). Used to detect VLA-4 affinity and conformational changes. Wavelengths are compatible with use as an acceptor dye in TR-FRET assays, together with the CoraFluor™ 1 (Cat. No. 7920) TR-FRET donor.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn2+ or antibody activation.
Chigaev et al.
J.Biol.Chem., 2001;276:48670 -
Conformational mAb as a tool for integrin ligand discovery.
Njus et al.
Assay Drug Dev.Technol., 2009;7:507 -
FRET detection of cellular α4-integrin conformational activation.
Chigaev et al.
Biophys.J., 2003;85:3951
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citation for LDV FITC
The citations listed below are publications that use Tocris products. Selected citations for LDV FITC include:
1 Citation: Showing 1 - 1
-
On-chip phenotypic analysis of inflammatory monocytes in atherogenesis and myocardial infarction.
Authors: Scott I Et al.
Proc Natl Acad Sci U S A 2013;110:13944-9
FAQs
No product specific FAQs exist for this product, however you may
View all Peptide FAQsReviews for LDV FITC
There are currently no reviews for this product. Be the first to review LDV FITC and earn rewards!
Have you used LDV FITC?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
