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NRX 252114

Catalog #: 7990 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7990/5
7990/25
NRX 252114 | CAS No. 2763260-39-3 | Molecular Glues
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Description: Molecular glue Degrader of mutant β-catenin

Chemical Name: 2-[[4-[(2,6-Dichlorophenyl)thio]-1,2-dihydro-2-oxo-6-(trifluoromethyl)-3-pyridinyl]carbonyl]-2,3-dihydro-1H-isoindole-4-carbonitrile

Purity: ≥98%

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Biological Activity

NRX-252114 is a potent enhancer of the interaction between S37A mutant β-catenin, and its cognate E3 ligase, SCFβ-TrCP (EC50 = 6.5 nM; Kd = 0.4 nM). NRX-252114 is a molecular glue degrader that binds at the phosphoserine binding site on β-TrCP and induces mutant β-catenin ubiquitination and subsequent degradation.

Technical Data

M.Wt:
510.31
Formula:
C22H12Cl2F3N3O2S
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2763260-39-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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