PP 2

Smooth muscle contraction and growth of stromal cells in the human prostate are both inhibited by the Src family kinase inhibitors, AZM475271 and PP2.
Authors: Wang Et al.
Br J Pharmacol  2016;173:3342

Progesterone receptor membrane component-1 regulates hepcidin biosynthesis.
Authors: Li Et al.
J Clin Invest  2016;126:389

The prion protein constitutively controls neuronal store-operated Ca(2+) entry through Fyn kinase.
Authors: Mario Et al.
Psychoneuroendocrinology  2015;9:416

Extracellular galectin-3 programs multidrug resistance through Na+/K+-ATPase and P-glycoprotein signaling.
Authors: Harazono Et al.
PLoS One  2015;6:19592

Anoikis resistance is a critical feature of highly aggressive ovarian cancer cells.
Authors: Cai Et al.
J Cell Sci  2015;34:3315

Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages.
Authors: Vijayakumar Et al.
Front Cell Neurosci  2015;128:251

mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
Authors: Kubota Et al.
PLoS One  2014;9:e106316

Long-term treatment with PP2 after spinal cord injury resulted in functional locomotor recovery and increased spared tissue.
Authors: Rosas Et al.
PLoS One  2014;9:2164

A role for intracellular zinc in glioma alteration of neuronal chloride equilibrium.
Authors: Angelantonio Et al.
Cell Death Dis  2014;5:e1501

Palmitate induces reactive oxygen species production and β-cell dysfunction by activating nicotinamide adenine dinucleotide phosphate oxidase through Src signaling.
Authors: Sato Et al.
Carcinogenesis  2014;5:19

Heat shock protein 90 inhibitors prevent LPS-induced endothelial barrier dysfunction by disrupting RhoA signaling.
Authors: Joshi Et al.
Am J Respir Cell Mol Biol  2014;50:170

BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals.
Authors: Chen Et al.
Eur J Neurosci  2014;39:1439

The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF receptor.
Authors: Wills Et al.
Mol Biol Cell  2014;25:739

Functional kinomics identifies candidate therapeutic targets in head and neck cancer.
Authors: Moser Et al.
Clin Cancer Res  2014;20:4274

Reelin signaling specifies the molecular identity of the pyramidal neuron distal dendritic compartment.
Authors: Kupferman Et al.
Neuron  2014;158:1335

A novel and essential role for FcγRIIa in cancer cell-induced platelet activation.
Authors: Mitrugno Et al.
Blood  2014;123:249

Characterisation of AmphiAmR11, an amphioxus (Branchiostoma floridae) D2-DA-like G protein-coupled receptor.
Authors: Bayliss and Evans
PLoS One  2013;8:e80833

Activation of ERK1/2 by store-operated calcium entry in rat parotid acinar cells.
Authors: Soltoff and Lannon
PLoS One  2013;8:e72881

SPIN90 phosphorylation modulates spine structure and synaptic function.
Authors: Cho Et al.
Mol Immunol  2013;8:e54276

Protein tyrosine phosphatase 1B modulates GSK3β/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity.
Authors: Mobasher Et al.
Cell Death Dis  2013;4:e626

Src kinase is a direct target of apigenin against UVB-induced skin inflammation.
Authors: Byun Et al.
Neuroscience  2013;34:397

Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL).
Authors: Vliet Et al.
J Biol Chem  2013;288:27519

Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair.
Authors: Leoni Et al.
J Clin Invest  2013;123:443

Apigenin inhibits NNK-induced focal adhesion kinase activation in pancreatic cancer cells.
Authors: Pham Et al.
Pancreas  2012;41:1306

β-OE unmasks metabotropic receptor-mediated metaplasticity of NMDA receptor transmission in the female rat dentate gyrus.
Authors: Nebieridze Et al.
Oncotarget  2012;37:1845

5-Hydroxytryptamine 5HT2C receptors form a protein complex with N-MthD.-aspartate GluN2A subunits and activate phosphorylation of Src protein to modulate motoneuronal depolarization.
Authors: Bigford Et al.
J Biol Chem  2012;287:11049

Mitochondrial localized STAT3 is involved in NGF induced neurite outgrowth.
Authors: Zhou and Too
Neural Regen Res  2011;6:e21680

Tamoxifen increases nuclear respiratory factor 1 transcription by activating estrogen receptor beta and AP-1 recruitment to adjacent promoter binding sites.
Authors: Ivanova Et al.
FASEB J  2011;25:1402

Genistein and tyrphostin AG556 inhibit inwardly-rectifying Kir2.1 channels expressed in HEK 293 cells via protein tyrosine kinase inhibition.
Authors: Zhang Et al.
Biochim Biophys Acta  2011;1808:1993

Epidermal growth factor receptor tyrosine kinase regulates the human inward rectifier potassium K(IR)2.3 channel, stably expressed in HEK 293 cells.
Authors: Zhang Et al.
Br J Pharmacol  2011;164:1469

Different responses in transformation of MDCK cells in 2D and 3D culture by v-Src as revealed by microarray techniques, RT-PCR and functional assays.
Authors: Töyli Et al.
Lab Invest  2010;90:915

Regulation of human cardiac KCNQ1/KCNE1 channel by epidermal growth factor receptor kinase.
Authors: Dong Et al.
Biochim Biophys Acta  2010;1798:995

FcεRI-induced activation by low antigen concentrations results in nuclear signals in the absence of degranulation.
Authors: Grodzki Et al.
Cell  2009;46:2539

Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines.
Authors: Hildebrand Et al.
J Neurosci  2009;29:9668

Beta1 integrin-dependent engulfment of Yersinia enterocolitica by macrophages is coupled to the activation of autophagy and suppressed by type III protein secretion.
Authors: Deuretzbacher Et al.
J Immunol  2009;183:5847

D1/5 receptor-mediated enhancement of LTP requires PKA, Src family kinases, and NR2B-containing NMDARs.
Authors: Stramiello
Neuropharmacology  2008;55:871

Coactivation of M(1) muscarinic and alpha1 adrenergic receptors stimulates extracellular signal-regulated protein kinase and induces long-term depression at CA3-CA1 synapses in rat hippocampus.
Authors: Scheiderer Et al.
J Neurosci  2008;28:5350

Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic DA neurons through nuclear receptors.
Authors: Melis Et al.
J Neurosci  2008;28:13985

Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior.
Authors: González-Maeso Et al.
J Diabetes Investig  2007;53:439

Rapid estrogenic regulation of extracellular signal- regulated kinase 1/2 signaling in cerebellar granule cells involves a G protein- and protein kinase A-dependent mechanism and intracellular activation of protein phosphatase 2A.
Authors: Belcher Et al.
Endocrinology  2005;146:5397

Differential effects of tyrosine kinase inhibitors on volume-sensitive chloride current in human atrial myocytes: evidence for dual regulation by Src and EGFR kinases.
Authors: Du Et al.
J Gen Physiol  2004;123:427