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Proteome Profiler Human Phospho-Kinase Array Kit

Catalog #: ARY003C
379 Citations 7 Reviews Datasheet / COA / SDS
Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 37 different kinases and 2 related total proteins
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Detection of human protein kinase phosphorylation in A549 Cell Line.
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Proteome Profiler Human Phospho-Kinase Array Kit Summary

Kit Summary

A membrane-based antibody array for the parallel determination of the relative levels of human protein kinase phosphorylation. Validated for analyte detection in cell lysates.

Troubleshooting Guide

Key Benefits

  • Detects phosphorylation of 37 human kinases and total amounts of 2 related proteins simultaneously
  • Requires no specialized equipment

 

Principle of the Assay

The Proteome Profiler Human Phospho-Kinase Array Kit is a membrane-based sandwich immunoassay. Capture antibodies spotted in duplicate on nitrocellulose membranes bind to specific target proteins present in the sample (Step 1). Captured proteins are detected with biotinylated detection antibodies (Step 2) and then visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount phosphorylation in the bound analyte.

Why Use an Antibody Array to Detect Receptor Phosphorylation?

Determining the phosphorylation of multiple kinases in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple phosphorylations in a single sample can be cost-effective and also save time and sample.

 

 

Kit Contents

Each Human Phospho-Kinase Antibody Array Kit contains most of the necessary components for a ready-to-run assay without the need for specialized equipment.

  • 8 Array Membranes (4 of membrane A and 4 of membrane B)
  • 8-Well Multi-dish
  • Lysis Buffer
  • Array Buffers
  • Wash Buffer
  • Detection Antibody Cocktail A
  • Detection Antibody Cocktail B
  • Streptavidin-HRP
  • Chemiluminescent Detection Reagents
  • Transparency Overlay Template
  • Detailed product datasheet with protocol

For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.

Stability and Storage

Store the unopened kit at 2°C to 8°C. Do not use past kit expiration date.

 
Simultaneously detect the relative phosphorylation of these proteins in a single sample.
Akt 1/2/3 (S473) HSP60 PRAS40 (T246)
Akt 1/2/3 (T308) JNK 1/2/3 (T183/Y185, T221/Y223) Pyk2 (Y402)
beta-Catenin Lck (Y394) RSK1/2 (S221/S227)
Chk-2 (T68) Lyn (Y397) RSK1/2/3 (S380/S386/S377)
c-Jun (S63) MSK1/2 (S376/S360) Src (Y419)
CREB (S133) p38 alpha (T180/Y182) STAT1 (Y701)
EGF R (Y1086) p53 (S15) STAT2 (Y689)
eNOS (S1177) p53 (S392) STAT3 (S727)
ERK1/2 (T202/Y204, T185/Y187) p53 (S46) STAT3 (Y705)
Fgr (Y412) P70 S6 Kinase (T389) STAT5a/b (Y699)
GSK-3 alpha/beta (S21/S9) p70 S6 Kinase (T421/S424) STAT6 (Y641)
GSK-3 beta (S9) PDGF R beta (Y751) WNK-1 (T60)
HSP27 (S78/S82) PLC gamma-1 (Y783) Yes (Y426)

 

Assays for analytes represented in the Human Phospho-Kinase Array Kit

 

Analyte DuoSet® IC ELISA Development Systems (Total) DuoSet® IC ELISA
Development Systems (Phospho)		 Quantikine®
ELISA Kits
Akt (S473)   DYC887B  
Akt (T308)      
beta-Catenin DYC1329    
Chk2 (T68)   DYC1626  
c-Jun (S63)      
CREB (S133)   DYC2510  
EGF R (Y1086) DYC1854   DEGFR0
eNOS (S1177)      
ERK1/2 (T202/Y204, T185/Y187)   DYC1018B  
Fgr (Y412)      
GSK-1 beta (S9)      
GSK-3 alpha/beta (S21/S9) DYC2157 DYC2630  
HSP27 (S78/S82) DYC1580 DYC2314  
HSP60 DYC1800    
JNK pan (T183/Y185, T221/Y223) DYC1205 DYC1387  
Lck (Y394)      
Lyn (Y397)   DYC3936  
MSK1/2 (S376/S360)      
p38 alpha (T180/Y182) DYC8691B DYC869B  
p53 (S15) DYC1043 DYC1839  
p53 (S46) DYC1043 DYC1489  
p53 (S392) DYC1043 DYC2996  
p70 S6 Kinase (T389)   DYC896  
p70 S6 Kinase (T421/S424) DYC8962 DYC8965  
PDGF R beta (Y751) DYC385 DYC3096  
PLC gamma-1 (Y783)      
PRAS40 (T246)   DYC6890  
PYK2 (Y402)      
RSK1/2 (S221/S227)      
RSK1/2/3 (S380/S386/S377)   DYC889B  
Src (Y419)   DYC2685  
STAT1 (Y701)      
STAT2 (Y689)      
STAT3 (S727)      
STAT3 (Y705)   DYC4607B  
STAT5a/b (Y694/Y699)      
STAT6 (Y641)      
WNK-1(T60)   DYC4720  
Yes (Y426)   DYC3929  

Specifications

Storage
Store the unopened product at 2 - 8 degreesC. Do not use past expiration date.
Species
Human

Product Datasheets

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Scientific Data

N/A Detection of human protein kinase phosphorylation in A549 Cell Line. View Larger

Detection of Human Protein Kinase Phosphorylation in A549 Cell Line. A549 human lung adenocarcinoma cells were either left untreated or exposed to 50 J/m2 of UV light followed by a 24 hour recovery before lysis.

N/A Detection of Human Protein Kinase Phosphorylation in Daudi Cell Line. View Larger

Detection of Human Protein Kinase Phosphorylation in Daudi Cell Line. Daudi human B cell lymphoma cells were either left untreated or treated with 500 U/ml recombinant human IFN-alpha 2a (R&D Systems®, Catalog # 11100-1) for 5 minutes.

N/A Detection of Human Protein Kinase Phosphorylation in Jurkat Cell Line. View Larger

Detection of Human Protein Kinase Phosphorylation in Jurkat Cell Line. Jurkat human acute T cell leukemia cells were either left untreated or treated with 100 ng/mL PMA and 0.5 mM Ionomycin for 20 minutes.

N/A Detection of Human Protein Kinase Phosphorylation in MCF-7 Cell Line. View Larger

Detection of Human Protein Kinase Phosphorylation in MCF-7 Cell Line. MCF-7 human breast cancer cells were either left untreated or treated with 100 ng/mL of recombinant human IGF-1 (R&D Systems®, Catalog # 291-G1) for 1 hour.

Citations for Proteome Profiler Human Phospho-Kinase Array Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

379 Citations: Showing 1 - 10
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  1. Co-targeting JAK1/STAT6/GAS6/TAM signaling improves chemotherapy efficacy in Ewing sarcoma
    Authors: Yu, L;Deng, Y;Wang, X;Santos, C;Davis, IJ;Earp, HS;Liu, P;
    Nature communications  2024-06-21
  2. Targeting dependency on a paralog pair of CBP/p300 against de-repression of KREMEN2 in SMARCB1-deficient cancers
    Authors: Sasaki, M;Kato, D;Murakami, K;Yoshida, H;Takase, S;Otsubo, T;Ogiwara, H;
    Nature communications  2024-06-05
  3. Differential effects of acute and chronic hydrocortisone treatment on pyroptosis
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    Heliyon  2024-05-30
  4. Selective targeting of IRAK1 attenuates low molecular weight hyaluronic acid-induced stemness and non-canonical STAT3 activation in epithelial ovarian cancer
    Authors: Standing, D;Dandawate, P;Gunewardena, S;Covarrubias-Zambrano, O;Roby, KF;Khabele, D;Jewell, A;Tawfik, O;Bossmann, SH;Godwin, AK;Weir, SJ;Jensen, RA;Anant, S;
    Cell death & disease  2024-05-25
  5. GSG2 promotes progression of human endometrial cancer by regulating PD-1/PD-L1 expression via PI3K-AKT pathway
    Authors: Chen, H;Liu, S;Wu, S;Nong, X;Liu, N;Li, L;
    International immunopharmacology  2024-05-16
  6. CD52 knockdown inhibits aerobic glycolysis and malignant behavior of NSCLC cells through AKT signaling pathway
    Authors: Cai, Y;Zhao, J;Luo, C;Fang, M;Yi, Y;Chen, Y;Huang, P;Liao, L;Huang, L;
    Journal of Cancer  2024-04-29
  7. Identification and In Vivo Validation of Unique Anti-Oncogenic Mechanisms Involving Protein Kinase Signaling and Autophagy Mediated by the Investigational Agent PV-10
    Authors: Tran, S;Sipila, P;Thakur, S;Zhang, C;Narendran, A;
    Cancers  2024-04-16
  8. Uncovering receptor-ligand interactions using a high-avidity CRISPR activation screening platform
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    Science advances  2024-02-16
  9. Novel Glycomimetics Protect against Glycated Low-Density Lipoprotein-Induced Vascular Calcification In Vitro via Attenuation of the RAGE/ERK/CREB Pathway
    Authors: Sidgwick, GP;Weston, R;Mahmoud, AM;Schiro, A;Serracino-Inglott, F;Tandel, SM;Skeoch, S;Bruce, IN;Jones, AM;Alexander, MY;Wilkinson, FL;
    Cells  2024-02-08
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    Cancer gene therapy  2024-02-02
  11. Kunitz-type protease inhibitor TFPI2 remodels stemness and immunosuppressive tumor microenvironment in glioblastoma
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    Nature immunology  2023-09-04
  12. Epithelial Galectin-3 Induced the Mitochondrial Complex Inhibition and Cell Cycle Arrest of CD8+ T Cells in Severe/Critical COVID-19
    Authors: Wang, Y;Yang, C;Wang, Z;Wang, Y;Yan, Q;Feng, Y;Liu, Y;Huang, J;Zhou, J;
    International journal of molecular sciences  2023-08-14
  13. Cannabidiol Enhances Cabozantinib-Induced Apoptotic Cell Death via Phosphorylation of p53 Regulated by ER Stress in Hepatocellular Carcinoma
    Authors: Jeon, Y;Kim, T;Kwon, H;Kim, JK;Park, YT;Ham, J;Kim, YJ;
    Cancers  2023-08-05
  14. Targeting of SLC25A22 boosts the immunotherapeutic response in KRAS-mutant colorectal cancer
    Authors: Zhou, Q;Peng, Y;Ji, F;Chen, H;Kang, W;Chan, LS;Gou, H;Lin, Y;Huang, P;Chen, D;Wei, Q;Su, H;Liang, C;Zhang, X;Yu, J;Wong, CC;
    Nature communications  2023-08-04
  15. Identification of Glucocorticoid Receptor Target Genes That Potentially Inhibit Collagen Synthesis in Human Dermal Fibroblasts
    Authors: Choi, D;Kang, W;Park, S;Son, B;Park, T;
    Biomolecules  2023-06-11
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    Authors: Pirttiniemi, A;Adeshara, K;Happonen, N;Einarsdottir, E;Katayama, S;Salmenkari, H;H�rkk�, S;Kere, J;Groop, PH;Lehto, M;
    Journal of leukocyte biology  2023-05-24
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    Authors: S Li, DM Pritchard, LG Yu
    Cell Death & Disease, 2023-04-13;14(4):268.  2023-04-13
  18. IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis
    Authors: W Lin, R Niu, SM Park, Y Zou, SS Kim, X Xia, S Xing, Q Yang, X Sun, Z Yuan, S Zhou, D Zhang, HJ Kwon, S Park, C Il Kim, H Koo, Y Liu, H Wu, M Zheng, H Yoo, B Shi, JB Park, J Yin
    Nature Communications, 2023-03-22;14(1):1578.  2023-03-22
  19. Venetoclax-Resistant T-ALL Cells Display Distinct Cancer Stem Cell Signatures and Enrichment of Cytokine Signaling
    Authors: K Shah, L Al Ashiri, A Nasimian, M Ahmed, JU Kazi
    International Journal of Molecular Sciences, 2023-03-05;24(5):.  2023-03-05
  20. EGFR and Lyn inhibition augments regorafenib induced cell death in sorafenib resistant 3D tumor spheroid model
    Authors: E Sar?yar, O Karpat, S Sezan, SM Baylan, A K?pçak, K Guven, E Erdal, ZF Karagonlar
    Cellular Signalling, 2023-01-21;0(0):110608.  2023-01-21
  21. Stellettin B Induces Cell Death in Bladder Cancer Via Activating the Autophagy/DAPK2/Apoptosis Signaling Cascade
    Authors: CH Chang, BJ Lin, CH Chen, NL Nguyen, TH Hsieh, JH Su, MC Chen
    Marine Drugs, 2023-01-21;21(2):.  2023-01-21
  22. HIF-1alpha accumulation in response to transient hypoglycemia may worsen diabetic eye disease
    Authors: C Guo, M Deshpande, Y Niu, I Kachwala, M Flores-Bel, H Megarity, T Nuse, S Babapoor-F, M Ramada, J Sanchez, N Inamdar, TV Johnson, MV Canto-Sole, S Montaner, A Sodhi
    Cell Reports, 2023-01-10;42(1):111976.  2023-01-10
  23. IL-1RA promotes oral squamous cell carcinoma malignancy through mitochondrial metabolism-mediated EGFR/JNK/SOX2 pathway
    Authors: Yuan, S;Wang, Y;Chan, L;Hung, A;Nguyen, H;Chen, Y;Hu, S;Lo, S;Wang, Y;
    Research Square  2023-01-01
  24. CCL4 Regulates Eosinophil Activation in Eosinophilic Airway Inflammation
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    International Journal of Molecular Sciences, 2022-12-18;23(24):.  2022-12-18
  25. Oxidized Proteins Differentially Affect Maturation and Activation of Human Monocyte-Derived Cells
    Authors: R Clemen, K Arlt, L Miebach, T von Woedtk, S Bekeschus
    Cells, 2022-11-18;11(22):.  2022-11-18
  26. BCG vaccinations drive epigenetic changes to the human T cell receptor: Restored expression in type 1 diabetes
    Authors: H Takahashi, WM Kühtreiber, RC Keefe, AH Lee, A Aristarkho, HF Dias, N Ng, KJ Nelson, S Bien, D Scheffey, DL Faustman
    Science Advances, 2022-11-16;8(46):eabq7240.  2022-11-16
  27. Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation
    Authors: M Schmitt, F Ceteci, J Gupta, M Pesic, TW Böttger, AM Nicolas, KB Kennel, E Engel, M Schewe, A Callak Kir, V Petrocelli, Y Dabiri, J Varga, M Ramakrishn, M Karimova, A Ablasser, T Sato, MC Arkan, FJ de Sauvage, FR Greten
    Nature, 2022-11-16;0(0):.  2022-11-16
  28. Extracellular Vesicles Isolated from Malignant Mesothelioma Cancer-Associated Fibroblasts Induce Pro-Oncogenic Changes in Healthy Mesothelial Cells
    Authors: T Chernova, S Grosso, XM Sun, AR Tenor, JZ Cabeza, A Craxton, EL Self, A Nakas, K Cain, M MacFarlane, AE Willis
    International Journal of Molecular Sciences, 2022-10-18;23(20):.  2022-10-18
  29. Loss of NECTIN1 triggers melanoma dissemination upon local IGF1 depletion
    Authors: J Ablain, A Al Mahi, H Rothschild, M Prasad, S Aires, S Yang, ME Dokukin, S Xu, M Dang, I Sokolov, CG Lian, LI Zon
    Nature Genetics, 2022-10-13;0(0):.  2022-10-13
  30. Resistance to tyrosine kinase inhibitors promotes renal cancer progression through MCPIP1 tumor-suppressor downregulation and c-Met activation
    Authors: P Marona, J Górka, O Kwapisz, J Jura, J Rys, RM Hoffman, K Miekus
    Cell Death & Disease, 2022-09-22;13(9):814.  2022-09-22
  31. Targeting Microtubule-Associated Protein Tau in Chemotherapy-Resistant Models of High-Grade Serous Ovarian Carcinoma
    Authors: MV Barbolina
    Cancers, 2022-09-19;14(18):.  2022-09-19
  32. Post-translational dysregulation of glucose uptake during exhaustive cycling exercise in vastus lateralis muscle of healthy homozygous carriers of the ACE deletion allele
    Authors: M Flück, D Vaughan, J Rittweger, MN Giraud
    Frontiers in Physiology, 2022-09-06;13(0):933792.  2022-09-06
  33. An in vivo model of glioblastoma radiation resistance identifies long non-coding RNAs and targetable kinases
    Authors: CT Stackhouse, JC Anderson, Z Yue, T Nguyen, NJ Eustace, CP Langford, J Wang, JR Rowland Iv, C Xing, FM Mikhail, X Cui, H Alrefai, RE Bash, KJ Lee, ES Yang, AB Hjelmeland, CR Miller, JY Chen, GY Gillespie, CD Willey
    JCI Insight, 2022-08-22;0(0):.  2022-08-22
  34. Macrophage SAMSN1 protects against sepsis-induced acute lung injury in mice
    Authors: W Jiang, C Ma, J Bai, X Du
    Redox Biology, 2022-08-13;56(0):102432.  2022-08-13
  35. PTEN inhibits AMPK to control collective migration
    Authors: F Peglion, L Capuana, I Perfettini, L Boucontet, B Braithwait, E Colucci-Gu, E Quissac, K Forsberg-N, F Llense, S Etienne-Ma
    Nature Communications, 2022-08-11;13(1):4528.  2022-08-11
  36. p38 MAPK-dependent phosphorylation of transcription factor SOX2 promotes an adaptive response to BRAF inhibitors in melanoma cells
    Authors: S Pietrobono, R De Paolo, D Mangiameli, A Marranci, I Battisti, C Franchin, G Arrigoni, D Melisi, L Poliseno, B Stecca
    The Journal of Biological Chemistry, 2022-08-07;298(9):102353.  2022-08-07
  37. Angiotensin II Exaggerates SARS-CoV-2 Specific T-Cell Response in Convalescent Individuals following COVID-19
    Authors: M Almutlaq, FA Mansour, J Alghamdi, Y Alhendi, AA Alamro, AA Alghamdi, HS Alamri, F Alroqi, T Barhoumi
    International Journal of Molecular Sciences, 2022-08-04;23(15):.  2022-08-04
  38. Exosomes from EGFR-Mutated Adenocarcinoma Induce a Hybrid EMT and MMP9-Dependant Tumor Invasion
    Authors: A Jouida, M O'Callagha, C Mc Carthy, A Fabre, P Nadarajan, MP Keane
    Cancers, 2022-08-03;14(15):.  2022-08-03
  39. Tsp2 Facilitates Tumor-associated Fibroblasts Formation and Promotes Tumor Progression in Retroperitoneal Liposarcoma
    Authors: C Xu, L Yan, X Guan, Z Wang, J Wu, A Lv, D Liu, F Liu, B Dong, M Zhao, L Jia, X Tian, C Hao
    International journal of biological sciences, 2022-08-01;18(13):5038-5055.  2022-08-01
  40. The human amniotic epithelium confers a bias to differentiate toward the neuroectoderm lineage in human embryonic stem cells
    Authors: D Ávila-Gonz, W Portillo, CP Barragán-Á, G Hernandez-, E Flores-Gar, A Molina-Her, NE Díaz-Martí, NF Díaz
    Elife, 2022-07-11;11(0):.  2022-07-11
  41. Kayadiol exerted anticancer effects through p53-mediated ferroptosis in NKTCL cells
    Authors: C He, C Wang, H Liu, B Shan
    BMC Cancer, 2022-07-02;22(1):724.  2022-07-02
  42. Macrophage-derived CCL23 upregulates expression of T-cell exhaustion markers in ovarian cancer
    Authors: K Kamat, V Krishnan, O Dorigo
    British Journal of Cancer, 2022-06-24;0(0):.  2022-06-24
  43. Peroxiredoxin IV plays a critical role in cancer cell growth and radioresistance through the activation of the Akt/GSK3 signaling pathways
    Authors: N Ding, H Jiang, P Thapa, Y Hao, A Alshahrani, D Allison, T Izumi, VM Rangnekar, X Liu, Q Wei
    The Journal of Biological Chemistry, 2022-06-10;0(0):102123.  2022-06-10
  44. GSK3beta palmitoylation mediated by ZDHHC4 promotes tumorigenicity of glioblastoma stem cells in temozolomide-resistant glioblastoma through the EZH2-STAT3 axis
    Authors: C Zhao, H Yu, X Fan, W Niu, J Fan, S Sun, M Gong, B Zhao, Z Fang, X Chen
    Oncogenesis, 2022-05-23;11(1):28.  2022-05-23
  45. Idelalisib activates AKT via increased recruitment of PI3Kdelta/PI3Kbeta to BCR signalosome while reducing PDK1 in post-therapy CLL cells
    Authors: MK Mamidi, H Mahmud, GP Maiti, MT Mendez, SM Fernandes, SK Vesely, J Holter-Cha, JR Brown, AK Ghosh
    Leukemia, 2022-05-14;0(0):.  2022-05-14
  46. m6A methylation mediates LHPP acetylation as a tumour aerobic glycolysis suppressor to improve the prognosis of gastric cancer
    Authors: JX Lin, NZ Lian, YX Gao, QL Zheng, YH Yang, YB Ma, ZS Xiu, QZ Qiu, HG Wang, CH Zheng, P Li, JW Xie, J Lu, QY Chen, LL Cao, M Lin, JB Wang, CM Huang
    Cell Death & Disease, 2022-05-14;13(5):463.  2022-05-14
  47. Ephrin B Activate Src Family Kinases in Fibroblasts Inducing Stromal Remodeling in Prostate Cancer
    Authors: M Kakarla, S ChallaSiva, MF Dufficy, V Gil, Y Filipovich, R Vickman, SE Crawford, SW Hayward, OE Franco
    Cancers, 2022-05-09;14(9):.  2022-05-09
  48. Melatonin Modulation of Radiation-Induced Molecular Changes in MCF-7 Human Breast Cancer Cells
    Authors: C Alonso-Gon, C González-A, J Menéndez-M, A González-G, V Álvarez-Ga, A González-C, C Martínez-C, S Cos
    Biomedicines, 2022-05-07;10(5):.  2022-05-07
  49. Non-canonical function of AGO2 augments T-cell receptor signaling in T-cell prolymphocytic leukemia
    Authors: T Braun, J Stachelsch, N Bley, S Oberbeck, M Otte, TA Müller, L Wahnschaff, M Gla beta, K Ommer, M Franitza, B Gathof, J Altmüller, M Hallek, D Auguin, S Hüttelmaie, A Schrader, M Herling
    Cancer Research, 2022-05-03;0(0):.  2022-05-03
  50. ICAM-1 promotes cancer progression by regulating SRC activity as an adapter protein in colorectal cancer
    Authors: EJ Lim, JH Kang, YJ Kim, S Kim, SJ Lee
    Cell Death & Disease, 2022-04-29;13(4):417.  2022-04-29
  51. The Fibrinogen-like Domain of ANGPTL3 Facilitates Lipolysis in 3T3-L1 Cells by Activating the Intracellular Erk Pathway
    Authors: S Bini, V Pecce, A Di Costanz, L Polito, A Ghadiri, I Minicocci, F Tambaro, S Covino, M Arca, L D'Erasmo
    Biomolecules, 2022-04-16;12(4):.  2022-04-16
  52. Microglia/macrophage-derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model
    Authors: Y Huang, E Motta, C Nanvuma, LD Kuhrt, Y Yuan, P Xia, M Lubas, S Zhu, M Schnauss, N Qazi, F Hu, H Zhang, T Lei, M Synowitz, C Flüh, H Kettenmann
    Cell Reports, 2022-04-12;39(2):110670.  2022-04-12
  53. Glycoproteogenomics characterizes the CD44 splicing code associated with bladder cancer invasion
    Authors: C Gaiteiro, J Soares, M Relvas-San, A Peixoto, D Ferreira, P Paulo, A Brandão, E Fernandes, R Azevedo, C Palmeira, R Freitas, A Miranda, H Osório, J Prieto, L Lima, AMN Silva, LL Santos, JA Ferreira
    Theranostics, 2022-03-28;12(7):3150-3177.  2022-03-28
  54. SLC4A4 promotes prostate cancer progression in vivo and in vitro via AKT-mediated signalling pathway
    Authors: Z Liu, Q Wang, G Zhai, S Ke, X Yu, J Guo
    Cancer Cell International, 2022-03-19;22(1):127.  2022-03-19
  55. ARAF suppresses ERBB3 expression and metastasis in a subset of lung cancers
    Authors: J Mooz, K Riegel, H Ps, A Sadanandam, F Marini, M Klein, U Werner, W Roth, A Wilken-Sch, I Tegeder, K Rajalingam
    Science Advances, 2022-03-18;8(11):eabk1538.  2022-03-18
  56. DDR1 promotes hepatocellular carcinoma metastasis through recruiting PSD4 to ARF6
    Authors: X Zhang, Y Hu, Y Pan, Y Xiong, Y Zhang, M Han, K Dong, J Song, H Liang, Z Ding, X Zhang, H Zhu, Q Liu, X Lu, Y Feng, X Chen, Z Zhang, B Zhang
    Oncogene, 2022-02-09;0(0):.  2022-02-09
  57. DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3
    Authors: CM Borza, G Bolas, F Bock, X Zhang, FC Akabogu, MZ Zhang, M de Caestec, M Yang, HC Yang, E Lee, L Gewin, AB Fogo, WH McDonald, R Zent, A Pozzi
    JCI Insight, 2022-02-08;0(0):.  2022-02-08
  58. Novel patient-derived models of DSRCT enable validation of ERBB signaling as a potential therapeutic vulnerability
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FAQs

  1. Why are there 8 membranes provided in ARY003C?

    • ARY003C contains 8 membranes because it is divided into parts A and B with 4 membranes each. Both parts are spotted with different antibodies to avoid interference and cross reactivity as well as maximize sensitivity. Parts A and B each contain 39 different capture antibodies printed in duplicate and should be used together for optimal analysis efficiency. A total of four samples can be run with this kit. 

View all Proteome Profiler Antibody Array FAQs

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Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 09/16/2021
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 07/15/2021
Proteome Profiler Human Phospho-Kinase Array Kit ARY003C
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 03/21/2021
Proteome Profiler Human Phospho-Kinase Array Kit ARY003C
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 01/27/2021
Proteome Profiler Human Phospho-Kinase Array Kit ARY003C
Proteome Profiler Human Phospho-Kinase Array Kit
By APK Inmunometabolismo on 11/06/2020
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 03/18/2020

Some of the antibodies lack sensitivity. Independent comprobation using the exact same protocol (lysis buffer, etc) and conventional WB rendered higher activation than the kit's

Proteome Profiler Human Phospho-Kinase Array Kit ARY003C
Proteome Profiler Human Phospho-Kinase Array Kit
By Anonymous on 01/21/2020
Proteome Profiler Human Phospho-Kinase Array Kit ARY003C