Tocrifluor T1117
Chemical Name: N-(Piperidin-1-yl)-5-(4-(4-(3-(5-carboxamidotetramethylrhodaminyl)propyl))phenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
Purity: ≥95%
Biological Activity
Tocrifluor T1117 is a fluorescent form of AM 251. AM 251 conjugated with 5-carboxytetramethylrhodamine (5-TAMRA) that fluoresces at 543 nm excitation (590 nm emission). Displays GPR55 binding activity. Wavelengths are compatible with use as an acceptor dye in TR-FRET assays, together with the CoraFluor™ 1 (Cat. No. 7920) TR-FRET donor.View more information regarding Tocrifluor T1117.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
- More information about Tocrifluor T1117
Background References
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Beyond radio-displacement techniques for identification of CB1 ligands: the first application of a fluorescence-quenching assay.
Bruno et al.
Sci.Rep., 2014;4:3757 -
Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses.
Sylantyev et al.
Proc.Natl.Acad.Sci.U.S.A., 2013;110:5193 -
Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries.
Daly et al.
Br.J.Pharmacol., 2010;159:787 -
Visualisation of vascular cannabinoid receptors and their potential interaction with α1-adrenergic receptors.
Daly et al.
Vascular and Smooth Muscle Phys.Soc. Symposium, 2008;
Product Datasheets
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Citations for Tocrifluor T1117
The citations listed below are publications that use Tocris products. Selected citations for Tocrifluor T1117 include:
3 Citations: Showing 1 - 3
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Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments.
Authors: Stornaiuolo Et al.
Sci Rep 2015;5:15453
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Targeted lipidomics in Drosophila melanogaster identifies novel 2-monoacylglycerols and N-acyl amides.
Authors: Tortoriello Et al.
PLoS One 2013;8:e67865
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Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries.
Authors: Daly Et al.
Br J Pharmacol 2010;159:787
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