TCF-2/HNF-1 beta: Products

TCF-2, also known as HNF-1 beta (Hepatocyte Nuclear Factor 1 beta) and VHNF-1, is a member of the HNF-1 homeobox family. By alternative splicing, three isoforms of TCF-2/HNF-1 beta exist. TCF-2/HNF-1 beta binds DNA as a homodimer or heterodimer with TCF-1/HNF-1 alpha. TCF-2 expression is required for visceral endoderm specification. Mutations in the TCF-2 gene are associated with maturity-onset diabetes of the young (MODY) type 5.