Home / Rho-kinase Inhibitors / Y-27632 dihydrochloride

Y-27632 dihydrochloride

Catalog #: 1254
251 Citations 3 Reviews Datasheet / COA / SDS
GMP Version Available: TB1254-GMP
GMP
Catalog # Availability Size / Price Qty
1254/10
1254/50
1254/1
Y-27632 dihydrochloride | CAS No. 129830-38-2 | Rho-kinase Inhibitors
2 Images
Description: Selective ROCK inhibitor; inhibits ROCK1 (p160 ROCK) and ROCK2; stem cell freezing (cryopreservation) media component
Alternative Names: y27632, Y-27632 2HCl, ROCK inhibitor, ROCK1 inhibitor

Chemical Name: trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride

Purity: ≥98%

Product Details
Citations (251)
Supplemental Products
Reviews (3)
Biological Activity Scientific Data Technical Data Background Product Datasheets Calculators

Biological Activity

Y-27632 dihydrochloride is a selective ROCK inhibitor (Ki values are 0.14-0.22, 0.3, 25, 26 and > 250 μM for ROCK1 (p160 ROCK), ROCK2, PKA, PKC and MLCK respectively). Also inhibits PRK2 (IC50 = 600 nM). Increases survival rate of human embryonic stem (hES) cells and iPSC undergoing cryopreservation. Used in combination with CHIR99021, RepSox, Forskolin, SP 600125, Go 6983 and VPA to reprogram fibroblasts to mature neurons. Also optimizes naive human pluripotent stem cell growth and viability following naive cell derivation from primed ESCs and iPSCs using naive human stem cell medium (NHSM). Used as component of growth media for urothelial organoids. Also used in a protocol to generate brain organoids from human iPSCs. Cell-permeable, orally bioavailable and active in vivo.

Y-27632 synthesized to cGMP guidelines also available.

For more information about how Y-27632 dihydrochloride may be used, see our protocols: Transdifferentiating Fibroblasts into Neurons, Converting Fibroblasts into Cardiomyocytes (9C Cocktail), Accelerated Induction of Cortical Neurons from hiPSCs, Human iPSC-derived Myoblasts.

Scientific Data

N/A ROCK inhibition by Y-27632 and immunostaining of skeletal myogenic differentiation of MESP1+ mesoderm, View Larger

Application of Y-27632 in MESP1+ Mesoderm. ROCK inhibition by Y-27632 (1 μM) promotes skeletal myogenic differentiation of MESP1+ mesoderm, as shown by immunostaining for Myosin Heavy Chain+ (Green) and Myogenin (Red), and counterstaining with DAPI (Catalog # 5748; Blue, Tocris). Data courtesy of Dr Sunny Chan and Dr Michael Kyba, University of Minnesota.

Technical Data

M.Wt:
320.26
Formula:
C14H21N3O.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
129830-38-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Derivation of novel human ground state naive pluripotent stem cells.
    Gafni O, Weinberger L, Mansour AA et al.
    Nature
  2. Cryopreservation of brain endothelial cells derived from human induced pluripotent stem cells is enhanced by Rho-associated coiled coil-containing kinase inhibition.
    Wilson et al.
    Tissue.Eng.Part C.Methods, 2016;22:1085
  3. Development of bipotent cardiac/skeletal myogenic progenitors from MESP1+ mesoderm.
    Chan et al.
    Stem Cell Reports, 2016;6:26
  4. Freeze-thawing single human embryonic stem cells induce e-cadherin and actin filament network disruption via g13 signaling.
    Ichikawa et al.
    Cryo Letters., 2011;32:516
  5. Use and properties of ROCK-specific inhibitor Y-27632.
    Narumiya et al.
    Methods Enzymol., 2000;325:273
  6. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase.
    Uehata et al.
    Nature, 1997;389:990
  7. In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.
    Bartfeld et al.
    Gastroenterology, 2015;148:126
  8. Generation of Cerebral Organoids from Human Pluripotent Stem Cells
    Lancaster et al.
    Nat.Protoc., 2015;9:2329
  9. SnapShot: Growing Organoids from Stem Cells.
    Sato et al.
    Cell, 2015;161:1700
  10. Establishment of gastrointestinal epithelial organoids
    Mahe et al.
    Curr.Protoc. Mouse Biol., 2014;3:217
  11. Human blood vessel organoids as a model of diabetic vasculopathy.
    Wimmer et al.
    Nature, 2019;565:505
  12. Isolation and in vitro expansion of human colonic stem cells.
    Jung et al.
    Nat.Med., 2011;17:1227
  13. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases.
    Ishizaki et al.
    Mol.Pharmacol., 2000;57:976
  14. Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity.
    Santos et al.
    Nat.Commun., 2019;10:4407
  15. Direct conversion of normal and Alzheimer's Disease human fibroblasts into neuronal cells by small molecules.
    Hu et al.
    Cell Stem Cell, 2015;17:204

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Y-27632 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Y-27632 dihydrochloride include:

251 Citations: Showing 1 - 10

  1. An in vivo neuroimmune organoid model to study human microglia phenotypes.
    Authors: Schafer Et al.
    Cell  2023;186:2111
  2. An improved protocol for generation and characterization of human-induced pluripotent stem cell-derived retinal pigment epithelium cells
    Authors: Surendran Et al.
    STAR Protoc  2022;3:101803
  3. Pancreatic islet cryopreservation by vitrification achieves high viability, function, recovery and clinical scalability for transplantation.
    Authors: Zhan Et al.
    Nat.Med.  2022;28:798
  4. Biphasic activation of WNT signaling facilitates the derivation of midbrain dopamine neurons from hESCs for translational use.
    Authors: Kim Et al.
    Cell Stem Cell  2021;28:343
  5. Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01
    Authors: Piao Et al.
    Cell Stem Cell  2021;28:217
  6. Generation of Complete Multi-Cell Type Lung Organoids From Human Embryonic and Patient-Specific Induced Pluripotent Stem Cells for Infectious Disease Modeling and Therapeutics Validation
    Authors: Leibel Et al.
    Curr Protoc Stem Cell Biol  2020;54:e118
  7. Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties.
    Authors: Panciera Et al.
    Nat Mater  2020;19:797
  8. Efficient Generation of Trunk Neural Crest and Sympathetic Neurons from Human Pluripotent Stem Cells Via a Neuromesodermal Axial Progenitor Intermediate.
    Authors: Frith and Tsakiridis
    Curr Protoc Stem Cell Biol  2019;:e81
  9. Multiparametric rapid screening of neuronal process pathology for drug target identification in HSP patient-specific neurons.
    Authors: Rehbach Et al.
    Sci Rep  2019;9:9615
  10. User-defined morphogen patterning for directing human cell fate stratification.
    Authors: Regier Et al.
    Sci Rep  2019;9:6433
  11. Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells.
    Authors: Martin-Gallausiaux Et al.
    Front Immunol  2019;9:2838
  12. Esomeprazole Increases Airway Surface Liquid pH in Primary Cystic Fibrosis Epithelial Cells.
    Authors: Delpiano Et al.
    Front Pharmacol  2019;9:1462
  13. Quantification of human neuromuscular function through optogenetics.
    Authors: Vila Et al.
    Theranostics  2019;9:1232
  14. Automated real-time monitoring of human pluripotent stem cell aggregation in stirred tank reactors.
    Authors: Schwedhelm Et al.
    Sci Rep  2019;9:12297
  15. The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest.
    Authors: Duman Et al.
    Elife  2019;8:e47566
  16. Evaluating Shigella flexneri pathogenesis in the human enteroid model.
    Authors: Ranganathan Et al.
    Infect Immun  2019;87
  17. The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and MetF. cytotoxicity in breast cancer.
    Authors: Zhuang Et al.
    Cancer Metab  2019;7:1
  18. Efficient generation of human primordial germ cell-like cells from pluripotent stem cells in a methylcellulose-based 3D system at large scale.
    Authors: Wang Et al.
    PeerJ  2019;6:e6143
  19. Highly Efficient CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells.
    Authors: Maguire Et al.
    Curr Protoc Stem Cell Biol  2019;48:e64
  20. Protective effects of oxymatrine against DSS-induced acute intestinal inflammation in mice via blocking the RhoA/ROCK signaling pathway.
    Authors: Wang Et al.
    Biosci Rep  2019;39
  21. Expansion of Luminal Progenitor Cells in the Aging Mouse and Human Prostate.
    Authors: Crowell Et al.
    Cell Rep  2019;28:1499
  22. Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development.
    Authors: Genga Et al.
    Cell Rep  2019;27:708
  23. Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies.
    Authors: Mair Et al.
    Cell Rep  2019;27:599
  24. An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons.
    Authors: Rhee Et al.
    Cell Rep  2019;27:2212
  25. A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons.
    Authors: Meijer Et al.
    Cell Rep  2019;27:2199
  26. Entosis Controls a Developmental Cell Clearance in C. elegans.
    Authors: Lee Et al.
    Cell Rep  2019;26:3212
  27. Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery.
    Authors: Larraufie Et al.
    Cell Rep  2019;26:1399
  28. A Stem-Cell-Derived Platform Enables Complete Cryptosporidium Development In Vitro and Genetic Tractability.
    Authors: Wilke Et al.
    Cell Host Microbe  2019;26:123
  29. Single-Cell Sequencing of iPSC-Da Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes.
    Authors: Lang Et al.
    Cell Stem Cell  2019;24:93
  30. Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells.
    Authors: Montel-Hagen Et al.
    Cell Stem Cell  2019;24:376
  31. Establishment of porcine and human expanded potential stem cells.
    Authors: Gao Et al.
    Nat Cell Biol  2019;21:687
  32. Nuclear envelope deformation controls cell cycle progression in response to mechanical force.
    Authors: Aureille Et al.
    EMBO Rep  2019;20:e48084
  33. Constructing an Isogenic 3D Human Nephrogenic Progenitor Cell Model Composed of Endothelial, Mesenchymal, and SIX2-Positive Renal Progenitor Cells.
    Authors: Nguyen Et al.
    Stem Cells Int  2019;2019:3298432
  34. A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cells.
    Authors: Chen Et al.
    Nat.Methods  2019;18:528
  35. Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment.
    Authors: Georgouli Et al.
    Cell  2019;176:757
  36. Identification of Kinases Responsible for p53-Dependent Autophagy.
    Authors: Celano Et al.
    iScience  2019;15:109
  37. FGF Modulates the Axial Identity of Trunk hPSC-Derived Neural Crest but Not the Cranial-Trunk Decision.
    Authors: Hackland Et al.
    Stem Cell Reports  2019;12:920
  38. Chemical conversion of human fetal astrocytes into neurons through modulation of multiple signaling pathways.
    Authors: Yin Et al.
    Stem Cell Reports  2019;12:488
  39. A Non-canonical Pathway with Potential for Safer Modulation of Transforming Growth Factor-β1 in Steroid-Resistant Airway Diseases.
    Authors: Li Et al.
    iScience  2019;12:232
  40. Exosomes regulate neurogenesis and circuit assembly.
    Authors: Sharma Et al.
    Proc Natl Acad Sci U S A  2019;116:16086
  41. Repurposed quinacrine synergizes with CIS. reducing the effective dose required for treatment of head and neck squamous cell carcinoma.
    Authors: Bryant Et al.
    Oncotarget  2019;10:5229
  42. Targeted gene silencing in human embryonic stem cells using cell-penetrating peptide PepFect 14.
    Authors: Ervin Et al.
    Stem Cell Res Ther  2019;10:43
  43. Dual stem cell therapy synergistically improves cardiac function and vascular regeneration following myocardial infarction.
    Authors: Park Et al.
    Nat Commun  2019;10:3123
  44. Modulation of Wnt/BMP pathways during corneal differentiation of hPSC maintains ABCG2-positive LSC population that demonstrates increased regenerative potential.
    Authors: Vattulainen Et al.
    Stem Cell Res Ther  2019;10:236
  45. Long-term culture of mesenchymal stem cells impairs ATM-dependent recognition of DNA breaks and increases genetic instability.
    Authors: Hladik Et al.
    Stem Cell Res Ther  2019;10:218
  46. Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory.
    Authors: Bertero Et al.
    Nat Commun  2019;10:1538
  47. TGF-β activation impairs fibroblast ability to support adult lung epithelial progenitor cell organoid formation.
    Authors: Ng-Blichfeldt Et al.
    Am J Physiol Lung Cell Mol Physiol  2019;
  48. Rho-Kinase Inhibition Ameliorates D.nib-Induced Endothelial Dysfunction and Pulmonary Hypertension.
    Authors: Fazakas Et al.
    Front Physiol  2018;9:537
  49. Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections.
    Authors: Ackermann Et al.
    Nat Commun  2018;9:5088
  50. A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation.
    Authors: Sheng Et al.
    Nat Commun  2018;9:4047
  51. Targeting the spliceosome for cutaneous squamous cell carcinoma therapy: a role for c-MYC and wild-type p53 in determining the degree of tumour selectivity.
    Authors: Hepburn Et al.
    Oncotarget  2018;9:23029
  52. Preclinical comparison of proteasome and ubiquitin E1 enzyme inhibitors in cutaneous squamous cell carcinoma: the identification of mechanisms of differential sensitivity.
    Authors: McHugh Et al.
    Oncotarget  2018;9:20265
  53. Effects of lung and airway epithelial maturation cocktail on the structure of lung bud organoids.
    Authors: Magro-Lopez Et al.
    Stem Cell Res.Ther.  2018;9:186
  54. Expansion of Airway Basal Cells and Generation of Polarized Epithelium.
    Authors: Levardon Et al.
    Bio Protoc  2018;8
  55. Generating Loss-of-function iPSC Lines with Combined CRISPR Indel Formation and Reprogramming from Human Fibroblasts.
    Authors: Tidball Et al.
    Bio Protoc  2018;8
  56. Rho-Kinase Inhibition Reduces Myofibroblast Differentiation and Proliferation of Scleral Fibroblasts Induced by Transforming Growth Factor β and Experimental Glaucoma.
    Authors: Pitha Et al.
    Transl Vis Sci Technol  2018;7:6
  57. Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth.
    Authors: Rath Et al.
    Cancer Res  2018;78:3321
  58. Lysophosphatidic Acid Induces ECM Production via Activation of the Mechanosensitive YAP/TAZ Transcriptional Pathway in Trabecular Meshwork Cells.
    Authors: Ho Et al.
    Invest Ophthalmol Vis Sci  2018;59:1969
  59. Advanced maturation of human cardiac tissue grown from pluripotent stem cells.
    Authors: Ronaldson-Bouchard Et al.
    Nature  2018;556:239
  60. α-Tubulin Acetyltransferase Is a Novel Target Mediating Neurite Growth Inhibitory Effects of Chondroitin Sulfate Proteoglycans and Myelin-Associated Glycoprotein.
    Authors: Wong Et al.
    Eneuro  2018;5
  61. Impaired adhesion of induced pluripotent stem cell-derived cardiac progenitor cells (iPSC-CPCs) to isolated extracellular matrix from failing hearts.
    Authors: McKown Et al.
    Heliyon  2018;4:e00870
  62. A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice.
    Authors: Ford Et al.
    Dev Cell  2018;47:509
  63. Derivation of Epithelial-Only Airway Organoids from Human Pluripotent Stem Cells.
    Authors: McCauley Et al.
    Curr Protoc Stem Cell Biol  2018;45:e51
  64. CRISPR/Cas9-based Targeted Genome Editing for the Development of Monogenic Diseases Models with Human Pluripotent Stem Cells.
    Authors: Gupta Et al.
    Curr Protoc Stem Cell Biol  2018;45:e50
  65. Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation.
    Authors: Ng-Blichfeldt Et al.
    EBioMedicine  2018;36:461
  66. PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5.
    Authors: Schaffer Et al.
    Cell Rep  2018;25:2470
  67. Human Huntington's Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and Maturation.
    Authors: Mehta Et al.
    Cell Rep  2018;25:1081
  68. Th17 lymphocytes induce neuronal cell death in a human iPSC-based model of Parkinson's disease.
    Authors: Sommer Et al.
    Cell Stem Cell.  2018;23:123
  69. Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium.
    Authors: Lynch Et al.
    Cell Stem Cell  2018;22:653
  70. Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1.
    Authors: Pirie Et al.
    PLoS Genet  2018;14:e1007732
  71. Neural stem cells for disease modeling and evaluation of therapeutics for infantile (CLN1/PPT1) and late infantile (CLN2/TPP1) neuronal ceroid lipofuscinoses.
    Authors: Sima Et al.
    Orphanet J Rare Dis  2018;13:54
  72. Use of human induced pluripotent stem cell-derived cardiomyocytes to assess drug cardiotoxicity.
    Authors: Sharma Et al.
    Nat Protoc  2018;13:3018
  73. Neural stem cells for disease modeling and evaluation of therapeutics for Tay-Sachs disease.
    Authors: Vu Et al.
    Orphanet J Rare Dis  2018;13:152
  74. Human Induced Pluripotent Stem Cell Production and Expansion from Blood using a Non-Integrating Viral Reprogramming Vector.
    Authors: Sharma Et al.
    Curr Protoc Mol Biol  2018;122:e58
  75. Generation of functioning nephrons by implanting human pluripotent stem cell-derived kidney progenitors.
    Authors: Bantounas Et al.
    Stem Cell Reports  2018;10:766
  76. Signaling-Dependent Control of Apical Membrane Size and Self-Renewal in Rosette-Stage Human Neuroepithelial Stem Cells.
    Authors: Medelnik Et al.
    Stem Cell Reports  2018;10:1751
  77. Differentiation of hepatocyte-like cells from human pluripotent stem cells using small molecules.
    Authors: Asumda Et al.
    Differentiation  2018;101:16
  78. ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth.
    Authors: Rath Et al.
    EMBO Mol Med  2017;9:198
  79. Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells.
    Authors: Sloan Et al.
    Neuron  2017;95:779
  80. iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases.
    Authors: Abud Et al.
    Neuron  2017;94:278
  81. Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors.
    Authors: Benedicto
    Nat Commun  2017;8:15374
  82. Dynamic behaviour of human neuroepithelial cells in the developing forebrain.
    Authors: Subramanian Et al.
    Nat Commun  2017;8:14167
  83. Membrane-bound ICAM-1 contributes to the onset of proinvasive tumor stroma by controlling acto-myosin contractility in carcinoma-associated fibroblasts.
    Authors: Bonan Et al.
    Oncotarget  2017;8:1304
  84. Atypical PKC and Notch Inhibition Differentially Modulate Cortical Interneuron Subclass Fate from Embryonic Stem Cells.
    Authors: Tischfield Et al.
    Stem Cell Reports  2017;8:1135
  85. Chemerin-induced arterial contraction is Gi- and calcium-dependent.
    Authors: Ferland Et al.
    Vascul Pharmacol  2017;88:30
  86. A pluripotent stem cell-based model for post-implantation human amniotic sac development.
    Authors: Shao
    Nat Commun  2017;8(1):208
  87. ASXL3 Is a Novel Pluripotency Factor in Human Respiratory Epithelial Cells and a Potential Therapeutic Target in Small Cell Lung Cancer.
    Authors: Shukla Et al.
    Cancer Res  2017;77:6267
  88. Discovery of Aromatic Carbamates that Confer Neuroprotective Activity by Enhancing Autophagy and Inducing the Anti-Apoptotic Protein B-Cell Lymphoma 2 (Bcl-2).
    Authors: Kinarivala Et al.
    J Med Chem  2017;60:9739
  89. Derivation of telencephalic oligodendrocyte progenitors from human pluripotent stem cells.
    Authors: Major Et al.
    Curr Protoc Stem Cell Biol  2017;39:1H.10.1
  90. A modular platform for differentiation of human PSCs into all major ectodermal lineages.
    Authors: Tchieu Et al.
    Cell Stem Cell.  2017;31:399
  91. Single-cell gene expression analysis reveals regulators of distinct cell subpopulations among developing human neurons.
    Authors: Wang Et al.
    Genome Res  2017;27:1783
  92. Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Adult Common Marmoset Fibroblasts.
    Authors: Vermilyea Et al.
    Stem Cells Dev  2017;26:1225
  93. Differentiation of human pluripotent stem cells into functional lung alveolar epithelial cells.
    Authors: Kotton Et al.
    Cell Stem Cell.  2017;21:472
  94. Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations.
    Authors: Lee Et al.
    Cell Stem Cell  2017;21:179
  95. Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling.
    Authors: McCauley Et al.
    Cell Stem Cell  2017;20:844
  96. Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia.
    Authors: Bershteyn Et al.
    Cell Stem Cell  2017;20:435
  97. Entosis Is Induced by Glucose Starvation.
    Authors: Hamann Et al.
    Cell Rep  2017;20:201
  98. In Vivo Human Somitogenesis Guides Somite Development from hPSCs.
    Authors: Xi
    Cell Rep  2017;18(6):1573
  99. Excitable Dynamics and Yap-Dependent Mechanical Cues Drive the Segmentation Clock.
    Authors: Hubaud Et al.
    Cell  2017;171:668
  100. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency.
    Authors: Yang Et al.
    Cell  2017;169:243
  101. An essential role of CBL and CBL-B ubiquitin ligases in mammary stem cell maintenance.
    Authors: Mohapatra Et al.
    Development  2017;144:1072
  102. Mesoderm-specific Stat3 deletion affects expression of Sox9 yielding Sox9-dependent phenotypes.
    Authors: Hall
    PLoS Genet  2017;13(2):e1006610
  103. Generation of nephron progenitor cells and kidney organoids from human pluripotent stem cells.
    Authors: Morizane and Bonventre
    Nat Protoc  2017;12:195
  104. Directed differentiation and long-term maintenance of epicardial cells derived from human pluripotent stem cells under fully defined conditions.
    Authors: Bao Et al.
    Nat Protoc  2017;12:1890
  105. Neural stem cells for disease modeling of Wolman disease and evaluation of therapeutics.
    Authors: Aguisanda Et al.
    Orphanet J Rare Dis  2017;12:120
  106. The novel cannabinoid receptor GPR55 mediates anxiolytic-like effects in the medial orbital cortex of mice with acute stress.
    Authors: Shi
    Mol Brain  2017;10(1):38
  107. The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ.
    Authors: Edwards Et al.
    Sci Signal  2017;10
  108. An in vitro model of murine middle ear epithelium.
    Authors: Mulay Et al.
    Dis Model Mech  2016;9:1405
  109. Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids
    Authors: Jardé Et al.
    Nature Communications  2016;7:13207
  110. Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6.
    Authors: Guye Et al.
    Sci Rep  2016;7:10243
  111. Nogo-A controls structural plasticity at dendritic spines by rapidly modulating actin dynamics.
    Authors: Kellner Et al.
    Hippocampus  2016;6:816
  112. Risk of prenatal depression and stress treatment: alteration on serotonin system of offspring through exposure to Fluox..
    Authors: Pei Et al.
    Sci Rep  2016;6:33822
  113. DArgic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects.
    Authors: Borgs Et al.
    Scientific Reports  2016;6:33377
  114. Regulation of actin dynamics by WNT-5A: implications for human airway smooth muscle contraction.
    Authors: Koopmans Et al.
    Sci Rep  2016;6:30676
  115. Tumor-induced remote ECM network orientation steers angiogenesis.
    Authors: Balcioglu Et al.
    Development  2016;6:22580
  116. Induced Pluripotent Stem Cells for Disease Modeling and Evaluation of Therapeutics for Niemann-Pick Disease Type A.
    Authors: Long Et al.
    Stem Cells Transl Med  2016;5:1644
  117. Local mechanical forces promote polarized junctional assembly and axis elongation in Drosophila.
    Authors: Yu and Fernandez-Gonzalez
    Elife  2016;5
  118. ROCK signalling induced gene expression changes in mouse pancreatic ductal adenocarcinoma cells.
    Authors: Rath Et al.
    Sci Data  2016;3:160101
  119. Elevated Glucose Levels Promote Contractile and Cytoskeletal Gene Expression in Vascular Smooth Muscle via Rho/Protein Kinase C and Actin Polymerization.
    Authors: Hien Et al.
    J Biol Chem  2016;291:3552
  120. Capturing the biology of disease severity in a PSC-based model of familial dysautonomia.
    Authors: Zeltner Et al.
    Nat Med  2016;22:1421
  121. Cryopreservation of Brain Endothelial Cells Derived from Human Induced Pluripotent Stem Cells Is Enhanced by Rho-Associated Coiled Coil-Containing Kinase Inhibition.
    Authors: Wilson Et al.
    Tissue Eng Part C Methods  2016;22:1085
  122. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells
    Authors: Mou Et al.
    Cell: Stem Cell  2016;19:217
  123. Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells.
    Authors: Manno Et al.
    Cell  2016;167:566
  124. Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology.
    Authors: Foulke-Abel Et al.
    Nat Commun  2016;150:638
  125. Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using humanpluripotent stem cells.
    Authors: Palpant Et al.
    Nature Protocols  2016;12:15
  126. Genomic Instability Associated with p53 Knockdown in the Generation of Huntington's Disease Human Induced Pluripotent Stem Cells.
    Authors: Tidball Et al.
    PLoS One  2016;11:e0150372
  127. Generation of human muscle fibers and satellite-like cells from human pluripotent stem cells in vitro.
    Authors: Chal Et al.
    Nat.Protoc.  2016;11:1833
  128. Differentiation and characterization of human pluripotent stem cell-derived brain microvascular endothelial cells.
    Authors: Stebbins Et al.
    Methods  2016;101:93
  129. Comparison of Human Embryonic Stem Cell-Derived Cardiomyocytes, Cardiovascular Progenitors, and Bone Marrow Mononuclear Cells for Cardiac Repair.
    Authors: Fernandes Et al.
    Bone Res  2015;NULL
  130. A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors.
    Authors: Rempel Et al.
    Arch Toxicol  2015;89:1599
  131. Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue.
    Authors: Sakaguchi Et al.
    Mol Vis  2015;6:8896
  132. A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis.
    Authors: Abraham Et al.
    Stem Cell Reports  2015;6:7286
  133. Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors.
    Authors: Edri Et al.
    Nat Commun  2015;6:6500
  134. Substrate stress relaxation regulates cell spreading.
    Authors: Chaudhuri Et al.
    Brain  2015;6:6364
  135. A therapy-grade protocol for differentiation of pluripotent stem cells into mesenchymal stem cells using platelet lysate as supplement.
    Authors: Luzzani Et al.
    Int J Cancer  2015;6:6
  136. Cloning-free CRISPR.
    Authors: Arbab Et al.
    Cell  2015;5:908
  137. Machine learning plus optical flow: a simple and sensitive method to detect cardioactive drugs.
    Authors: Lee Et al.
    Sci Rep  2015;5:11817
  138. Dynamic tensile forces drive collective cell migration through three-dimensional extracellular matrices.
    Authors: Gjorevski Et al.
    Sci Rep  2015;5:11458
  139. A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics.
    Authors: Romero Et al.
    Elife  2015;4:e07103
  140. Defined conditions for the isolation and expansion of basal prostate progenitor cells of mouse and human origin.
    Authors: Höfner Et al.
    PLoS One  2015;4:503
  141. Large-scale hematopoietic differentiation of human induced pluripotent stem cells provides granulocytes or macrophages for cell replacement therapies.
    Authors: Lachmann Et al.
    Nat Commun  2015;4:282
  142. Rho/Rock signal transduction pathway is required for MSC tenogenic differentiation.
    Authors: Maharam Et al.
    Stem Cell Res Ther  2015;3:15015
  143. Nephron organoids derived from human pluripotent stem cells model kidney development and injury.
    Authors: Morizane Et al.
    Nat Commun  2015;33:1193
  144. Odontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling.
    Authors: Lee Et al.
    Toxicol Sci  2015;290:14740
  145. Phenotypes of trypsin- and Col. -prepared bovine corneal endothelial cells in the presence of a selective Rho kinase inhibitor, Y-27632.
    Authors: Su Et al.
    PLoS Comput Biol  2015;21:633
  146. RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork.
    Authors: Pattabiraman Et al.
    Autophagy  2015;185:496
  147. Transgenic plants as low-cost platform for chemotherapeutic drugs screening.
    Authors: Vergara Et al.
    J Biol Chem  2015;16:2174
  148. Human embryonic stem cell-derived oligodendrocyte progenitors remyelinate the brain and rescue behavioral deficits following radiation.
    Authors: Piao Et al.
    Cell Stem Cell  2015;16:198
  149. Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis.
    Authors: Madsen Et al.
    EMBO Rep  2015;16:1394
  150. Cortical contractility triggers a stochastic switch to fast amoeboid cell motility.
    Authors: Ruprecht Et al.
    Int J Mol Sci  2015;160:673
  151. Comprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor.
    Authors: Jönsson Et al.
    Int J Nanomedicine  2015;142:3166
  152. Duration of culture and sonic hedgehog signaling differentially specify PV versus SST cortical interneuron fates from embryonic stem cells.
    Authors: Tyson Et al.
    Stem Cells  2015;142:1267
  153. Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations.
    Authors: Iovino Et al.
    Development  2015;138:3345
  154. SDF-1α stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II.
    Authors: Choi Et al.
    Stem Cell Reports  2015;136:E219
  155. The integrin expression profile modulates orientation and dynamics of force transmission at cell-matrix adhesions.
    Authors: Balcioglu Et al.
    Nat Biotechnol  2015;128:1316
  156. Quantitative Live Imaging of Human Embryonic Stem Cell Derived Neural Rosettes Reveals Structure-Function Dynamics Coupled to Cortical Development.
    Authors: Ziv Et al.
    Stem Cell Reports  2015;11:e1004453
  157. Variations in Glycogen Synthesis in Human Pluripotent Stem Cells with Altered Pluripotent States.
    Authors: Chen Et al.
    PLoS One  2015;10:e0142554
  158. The Viral Mimetic Polyinosinic:Polycytidylic Acid Alters the Growth Characteristics of Small Intestinal and Colonic Crypt Cultures.
    Authors: Davies Et al.
    PLoS One  2015;10:e0138531
  159. SimV. Increases Fibulin-2 Expression in Human Coronary Artery Smooth Muscle Cells via RhoA/Rho-Kinase Signaling Pathway Inhibition.
    Authors: Serra Et al.
    PLoS One  2015;10:e0133875
  160. Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development.
    Authors: Härmä Et al.
    Stem Cell Reports  2015;10:e0126111
  161. SimV. enhances Rho/actin/cell rigidity pathway contributing to mesenchymal stem cells' osteogenic differentiation.
    Authors: Tai Et al.
    Nat Commun  2015;10:5881
  162. Molecular beacon-enabled purification of living cells by targeting cell type-specific mRNAs.
    Authors: Wile Et al.
    Nat Protoc  2014;9:2411
  163. Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis.
    Authors: Moon Et al.
    Mucosal Immunol  2014;7:818
  164. TRPA1 is essential for the vascular response to environmental cold exposure.
    Authors: Aubdool Et al.
    Korean J Physiol Pharmacol  2014;5:5732
  165. Diverse matrix metalloproteinase functions regulate cancer amoeboid migration.
    Authors: Orgaz Et al.
    Nat Commun  2014;5:4255
  166. Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism.
    Authors: Cossette Et al.
    Biol Open  2014;4:48
  167. Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain.
    Authors: Mich Et al.
    Elife  2014;3:e02669
  168. Derivation and expansion of PAX7-positive muscle progenitors from human and mouse embryonic stem cells.
    Authors: Shelton Et al.
    Stem Cell Reports  2014;3:516
  169. The atypical Rho GTPase, RhoU, regulates cell-adhesion molecules during cardiac morphogenesis.
    Authors: Dickover Et al.
    Dev Biol  2014;389:182
  170. Age-dependent contribution of Rho kinase in CB-induced contraction of human detrusor smooth muscle in vitro.
    Authors: Kirschstein Et al.
    Acta Pharmacol Sin  2014;35:74
  171. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells.
    Authors: Huang Et al.
    Nat Biotechnol  2014;32:84
  172. Cryopreservation of human pluripotent stem cells in defined medium.
    Authors: Liu and Chen
    Curr Protoc Stem Cell Biol  2014;31:1C.17.1
  173. Generation of GFP Reporter Human Induced Pluripotent Stem Cells Using AAVS1 Safe Harbor Transcription Activator-Like Effector Nuclease.
    Authors: Luo Et al.
    Curr Protoc Stem Cell Biol  2014;29:5A.7.1
  174. Role of Rho GDP dissociation inhibitor α in control of epithelial sodium channel (ENaC)-mediated sodium reabsorption.
    Authors: Pavlov Et al.
    J Biol Chem  2014;289:28651
  175. Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry.
    Authors: Feng Et al.
    Cancer Cell  2014;25:831
  176. GABAergic terminals are a source of galanin to modulate cholinergic neuron development in the neonatal forebrain.
    Authors: Keimpema Et al.
    Cereb Cortex  2014;24:3277
  177. Competition between human cells by entosis.
    Authors: Sun Et al.
    Cell Res  2014;24:1299
  178. Induction of entosis by epithelial cadherin expression.
    Authors: Sun Et al.
    Cell Res  2014;24:1288
  179. Transforming growth factor β-induced superficial zone protein accumulation in the surface zone of articular cartilage is dependent on the cytoskeleton.
    Authors: McNary Et al.
    Tissue Eng Part A  2014;20:921
  180. An in vivo role for Rho kinase activation in the tumour vascular disrupting activity of combretastatin A-4 3-O-phosphate.
    Authors: Williams Et al.
    Br J Pharmacol  2014;171:4902
  181. A high-throughput screen for teratogens using human pluripotent stem cells.
    Authors: Kameoka Et al.
    J Biomol Screen  2014;137:76
  182. Signals from the surface modulate differentiation of human pluripotent stem cells through glycosaminoglycans and integrins.
    Authors: Wrighton Et al.
    Circ Res  2014;111:18126
  183. The role of mechanical force and ROS in integrin-dependent signals.
    Authors: Zeller Et al.
    PLoS One  2013;8:e64897
  184. Fluid-phase pinocytosis of native low density lipoprotein promotes murine M-CSF differentiated macrophage foam cell formation.
    Authors: Barthwal Et al.
    PLoS One  2013;8:e58054
  185. Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation.
    Authors: Matsumoto Et al.
    Orphanet J Rare Dis  2013;8:190
  186. Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions.
    Authors: Lian Et al.
    Nat Protoc  2013;8:162
  187. Generating regionalized neuronal cells from pluripotency, a step-by-step protocol.
    Authors: Kirkeby Et al.
    Front Cell Neurosci  2013;6:64
  188. Activation of β 1 but not β 3 integrin increases cell traction forces.
    Authors: Lin Et al.
    J Neurosci  2013;587:763
  189. Generation of integration-free and region-specific neural progenitors from primate fibroblasts.
    Authors: Lu Et al.
    Curr Biol  2013;3:1580
  190. PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively.
    Authors: Zhu and Nelson
    Cell  2013;379:235
  191. Calcium release-dependent actin flow in the leading process mediates axophilic migration.
    Authors: Hutchins Et al.
    J Cell Biochem  2013;33:11361
  192. mTOR regulates phagosome and entotic vacuole fission.
    Authors: Krajcovic Et al.
    Mol Biol Cell  2013;24:3736
  193. Sox10-MCS5 enhancer dynamically tracks human oligodendrocyte progenitor fate.
    Authors: Pol Et al.
    Stem Cell Res  2013;247:694
  194. A phenotypic screening assay for modulators of huntingtin-induced transcriptional dysregulation.
    Authors: Lazzeroni Et al.
    Exp Neurol  2013;18:984
  195. A phenotypic screening assay for modulators of huntingtin-induced transcriptional dysregulation
    Authors: Lazzeroni Et al.
    J Biomol Screen  2013;18:984
  196. Inhibition of Rho-kinase improves erectile function, increases nitric oxide signaling and decreases penile apoptosis in a rat model of cavernous nerve injury.
    Authors: Hannan Et al.
    Am J Physiol Lung Cell Mol Physiol  2013;189:1155
  197. Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts.
    Authors: Calvo Et al.
    Nat Cell Biol  2013;15:637
  198. The microtubule end-binding protein EB2 is a central regulator of microtubule reorganisation in apico-basal epithelial differentiation.
    Authors: Goldspink Et al.
    J Cell Sci  2013;126:4000
  199. Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling.
    Authors: Crompton Et al.
    Nat Cell Biol  2013;11:1206
  200. Interleukin-6 and oncostatin-M synergize with the PI3K/AKT pathway to promote aggressive prostate malignancy in mouse and human tissues.
    Authors: Smith Et al.
    Mol Cancer Res  2013;11:1159
  201. Shaping organs by a wingless-int/Notch/nonmuscle myosin module which orients feather bud elongation.
    Authors: Li Et al.
    Proc Natl Acad Sci U S A  2013;110:E1452
  202. ZFX controls the self-renewal of human embryonic stem cells.
    Authors: Harel Et al.
    PLoS One  2012;7:e42302
  203. Passaging and colony expansion of human pluripotent stem cells by enzyme-free dissociation in chemically defined culture conditions.
    Authors: Beers Et al.
    Nat Protoc  2012;7:2029
  204. DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction.
    Authors: Neely Et al.
    Proc Natl Acad Sci U S A  2012;3:482
  205. Soluble epoxide hydrolase: sex differences and role in endothelial cell survival.
    Authors: Gupta Et al.
    Arterioscler Thromb Vasc Biol  2012;32:1936
  206. Intra-axonal translation of RhoA promotes axon growth inhibition by CSPG.
    Authors: Walker Et al.
    J Cell Sci  2012;32:14442
  207. Pregnancy reduces RhoA/Rho kinase and protein kinase C signaling pathways downstream of thromboxane receptor activation in the rat uterine artery.
    Authors: Goulopoulou Et al.
    Am J Physiol Heart Circ Physiol  2012;302:H2477
  208. Neuritogenesis: the prion protein controls β1 integrin signaling activity.
    Authors: Loubet Et al.
    FASEB J  2012;26:678
  209. A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development.
    Authors: Paige Et al.
    Cell  2012;151:221
  210. Slug and Sox9 cooperatively determine the mammary stem cell state.
    Authors: Guo Et al.
    J Cell Sci  2012;148:1015
  211. Synthetic lethal screening with small-molecule inhibitors provides a pathway to rational combination therapies for melanoma.
    Authors: Roller Et al.
    Mol Cancer Ther  2012;11:2505
  212. Measurement and analysis of traction force dynamics in response to vasoactive agonists.
    Authors: Yang Et al.
    Integr Biol (Camb)  2011;3:663
  213. RhoJ/TCL regulates endothelial motility and tube formation and modulates actomyosin contractility and focal adhesion numbers.
    Authors: Kaur Et al.
    Arterioscler Thromb Vasc Biol  2011;31:657
  214. Cell wound repair in Drosophila occurs through three distinct phases of membrane and cytoskeletal remodeling.
    Authors: Abreu-Blanco Et al.
    J Cell Biol  2011;193:455
  215. The Relaxing Effect of α-Defensin 1 on the Adrenergic Responses of Rat Bladder.
    Authors: Lee Et al.
    Dev Biol  2011;15:143
  216. Wnt signaling specifies and patterns intestinal endoderm.
    Authors: Sherwood Et al.
    Mech Dev  2011;128:387
  217. An association between NUAK2 and MRIP reveals a novel mechanism for regulation of actin stress fibers.
    Authors: Vallenius Et al.
    Integr Biol (Camb)  2011;124:384
  218. Assessment of chemical-induced impairment of human neurite outgrowth by multiparametric live cell imaging in high-density cultures.
    Authors: Stiegler Et al.
    Toxicol Sci  2011;121:73
  219. STAT inhibit angiotensin II/Smad pathway and related vascular fibrosis, by a TGF-β-independent process.
    Authors: Díez Et al.
    PLoS One  2010;5:e14145
  220. Endogenous patterns of mechanical stress are required for branching morphogenesis.
    Authors: Gjorevski and Nelson
    Stroke  2010;2:424
  221. Cortical actin dynamics facilitate early-stage centrosome separation.
    Authors: Cao Et al.
    J Pharmacol Exp Ther  2010;20:770
  222. Rho-kinase directs Bazooka/Par-3 planar polarity during Drosophila axis elongation.
    Authors: Simões Et al.
    Dev Cell  2010;19:377
  223. Tissue geometry patterns epithelial-mesenchymal transition via intercellular mechanotransduction.
    Authors: Gomez Et al.
    ACS Chem Neurosci  2010;110:44
  224. PDGF signaling is required for epicardial function and blood vessel formation in regenerating zebrafish hearts.
    Authors: Kim Et al.
    FEBS Lett  2010;107:17206
  225. The Rho-A/Rho-kinase pathway is up-regulated but remains inhibited by cyclic guanosine monophosphate-dependent mechanisms during endotoxemia in small mesenteric arteries.
    Authors: Silva-Santos Et al.
    J Biol Chem  2009;37:1716
  226. Cell polarity triggered by cell-cell adhesion via E-cadherin.
    Authors: Desai Et al.
    Br J Pharmacol  2009;122:905
  227. Localized and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motility.
    Authors: Giampieri Et al.
    Nat Commun  2009;11:1287
  228. Essential role of TGF-beta/Smad pathway on statin dependent vascular smooth muscle cell regulation.
    Authors: Rodríguez-Vita Et al.
    PLoS One  2008;3:e3959
  229. Emergence of patterned stem cell differentiation within multicellular structures.
    Authors: Ruiz and Chen
    J Cell Sci  2008;26:2921
  230. Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice.
    Authors: Inan and Büyükafşar
    Am J Pathol  2008;155:44
  231. Quantifying myosin light chain phosphorylation in single adherent cells with automated fluorescence microscopy.
    Authors: Bhadriraju Et al.
    J Biol Chem  2007;8:43
  232. Ins induces airway smooth muscle contraction.
    Authors: Schaafsma Et al.
    Cell Rep  2007;150:136
  233. Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by AtoVas.
    Authors: Muñoz-García Et al.
    Proc Natl Acad Sci U S A  2006;37:2044
  234. Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoA.
    Authors: Guillemot and Citi
    Mol Biol Cell  2006;17:3569
  235. ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo.
    Authors: Wyckoff Et al.
    Curr Biol  2006;16:1515
  236. Temporally and spatially coordinated roles for Rho, Rac, Cdc42 and their effectors in growth cone guidance by a physiological electric field.
    Authors: Rajnicek Et al.
    J Cell Sci  2006;119:1723
  237. Endothelin-1, via ETA receptor and independently of transforming growth factor-β, increases the connective tissue growth factor in vascular smooth muscle cells.
    Authors: Rodríguez-Vita Et al.
    Am J Physiol Cell Physiol  2005;97:125
  238. CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells.
    Authors: Hartmann Et al.
    Oncogene  2005;24:4462
  239. Signal transduction underlying CB-induced contraction of human urinary bladder.
    Authors: Schneider Et al.
    J Biol Chem  2004;309:1148
  240. Signal transduction underlying CB-induced contraction of rat urinary bladder. II. Protein kinases.
    Authors: Fleichman Et al.
    J Pharmacol Exp Ther  2004;308:54
  241. Regulation of MDCK cell-substratum adhesion by RhoA and myosin light chain kinase after ATP depletion.
    Authors: Prahalad Et al.
    Am J Physiol Cell Physiol  2004;286:C693
  242. The activity of the plexin-A1 receptor is regulated by Rac.
    Authors: Turner Et al.
    J Biol Chem  2004;279:33199
  243. Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA.
    Authors: Surks Et al.
    J Biol Chem  2003;278:51484
  244. Effects of rho kinase and actin stress fibers on sustained extracellular signal-regulated kinase activity and activation of G(1) phase cyclin-dependent kinases.
    Authors: Roovers and Assoian
    Mol Cell Biol  2003;23:4283
  245. Expression and functional role of Rho-kinase in rat urinary bladder smooth muscle.
    Authors: Wibberley Et al.
    Br J Pharmacol  2003;138:757
  246. Comparison of signalling mechanisms involved in rat mesenteric microvessel contraction by noradrenaline and sphingosylphosphorylcholine.
    Authors: Altmann Et al.
    Br J Pharmacol  2003;138:261
  247. Rho protein inactivation induced apoptosis of cultured human endothelial cells.
    Authors: Hippenstiel Et al.
    BMC Cell Biol  2002;283:L830
  248. Stiffness changes in cultured airway smooth muscle cells.
    Authors: An Et al.
    Gastroenterology  2002;283:C792
  249. Interaction of cofilin with triose-phosphate isomerase contributes glycolytic fuel for Na,K-ATPase via Rho-mediated signaling pathway.
    Authors: Jung Et al.
    Br J Pharmacol  2002;277:48931
  250. Differential regulation of cell migration, actin stress fiber organization, and cell transformation by functional domains of Crk-associated substrate.
    Authors: Huang Et al.
    Crit Care Med  2002;277:27265
  251. Myelin-associated glycoprotein interacts with ganglioside GT1b. A mechanism for neurite outgrowth inhibition.
    Authors: Vinson Et al.
    J Urol  2001;276:20280

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Y-27632 dihydrochloride

Average Rating: 5 (Based on 3 Reviews)

5 Star
18.75%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used Y-27632 dihydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


In vitro study
By Emma Watson on 08/31/2021
Species: Human

for human iPSC cells

PDX organoid culture
By Puru Lamichhane on 03/14/2021
Species: Human

PDX organoid culture

Human PDAC orgnaoids
By Anonymous on 05/03/2019
Species: Human

To make Human PDAC orgnaoids

Human PDAC orgnaoids 1254
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.