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Prolyl hydroxylase inhibitor
HIF-1α inhibitor; down-regulates HIF-1α protein synthesis
Highly potent and selective HIF-1α inhibitor
High affinity and selective HIF-2α inhibitor
Selective HIF-1 dimerization inhibitor
Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor
HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant
Malate dehydrogenase-2 (MDH2) inhibitor; also inhibits HIF-1α