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Promotes HSCs expansion; increases HSCs engraftment; also endogenous prostaglandin
PORCN inhibitor; inhibits Wnt processing and secretion
Potent tankyrase inhibitor
Wnt/β-catenin signaling inhibitor; axin stabilizer
ROCK inhibitor; improves the efficiency of fibroblast reprogramming and induction of iPSCs
Inhibitor of Hedgehog (Hh) signaling
p53 inhibitor. Also aryl hydrocarbon receptor agonist
XAV 939 synthesized to cGMP guidelines
Potent GSK-3 inhibitor; also inhibits cdks
GLI antagonist; inhibits Hedgehog (Hh) signaling
STAT3 inhibitor; also inhibits mTORC1 signaling
Selective Hsp90 inhibitor
Synthetic prostaglandin E2 (Cat. No. 2296) derivative; regulates HSC development
Allosteric activator of Hedgehog (Hh) signaling; induces Smo accumulation
Potent, selective Rho-kinase (ROCK) inhibitor
Hedgehog (Hh) pathway antagonist, inhibits ciliogenesis; also inhibits dynein
GSK-3β inhibitor; also inhibits cdks
ARFGAP1 inhibitor; modulates Wnt/β-catenin signaling
Breast cancer stem cell inhibitor
Potent tankyrase inhibitor
Inhibits proliferation and induces apoptosis selectively in pancreatic CSCs and cancer cell lines
Potent and selective LATS inhibitor; activates YAP signaling